The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double-Blind Prospective Study
The hemodynamic effects of intravenous ranitidine were studied in a prospective double‐blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidin...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical pharmacology 1988-12, Vol.28 (12), p.1098-1100 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1100 |
|---|---|
| container_issue | 12 |
| container_start_page | 1098 |
| container_title | Journal of clinical pharmacology |
| container_volume | 28 |
| creator | Onofrey, David Kelly, Kathleen M. Gentili, David R. Benjamin, Ernest Iberti, Thomas J. |
| description | The hemodynamic effects of intravenous ranitidine were studied in a prospective double‐blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found no statistically significant hemodynamic changes from baseline associated with infusion of 50 mg ranitidine over a 5‐minute period. The different chemical ring structure of ranitidine and its effect on H2 vascular and cardiac receptors may account for these observations. |
| doi_str_mv | 10.1002/j.1552-4604.1988.tb05722.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78737512</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78737512</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4382-2d40258c9f2ee881dfbd025b3b7525ce686e64816f54f57968199300e2f84df53</originalsourceid><addsrcrecordid>eNqVkEFv1DAQhS0EKkvhJyBZCHFLsJ3YcXqiLKVb2MICrThaTjwWXhJniZOy--9xtNHeOY0175vnmYfQK0pSSgh7u00p5yzJBclTWkqZDhXhBWPp_hFanKTHaEFISRNWEPIUPQthSwgVOadn6CxjeVYysUDh7hfgFbSdOXjduhpfWQv1EHBn8Y0fev0AvhsD_q69G5xxHrDzkwI-uAfAS90Dvo8a3ujBgR_CBb7EH7qxaiB53zhv8Kbvwi56TviPYTSH5-iJ1U2AF3M9R_cfr-6Wq2T99fpmeblO6jyTLGEmJ4zLurQMQEpqbGVio8qqgjNeg5ACRC6psDy3vCiFpGWZEQLMytxYnp2jN0ffXd_9GSEMqnWhhqbRHuJNqpBFVnDKInhxBOu4aujBql3vWt0fFCVqSlxt1RSrmmJVU-JqTlzt4_DL-ZexasGcRueIo_561nWodWN77WsXTpgQJSdCRuzdEfvrGjj8xwLq03Kzmp7RIjlauDDA_mSh-99KTJeqn1-u1e16xcm3W6Y-Z_8AUP6s3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78737512</pqid></control><display><type>article</type><title>The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double-Blind Prospective Study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Onofrey, David ; Kelly, Kathleen M. ; Gentili, David R. ; Benjamin, Ernest ; Iberti, Thomas J.</creator><creatorcontrib>Onofrey, David ; Kelly, Kathleen M. ; Gentili, David R. ; Benjamin, Ernest ; Iberti, Thomas J.</creatorcontrib><description>The hemodynamic effects of intravenous ranitidine were studied in a prospective double‐blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found no statistically significant hemodynamic changes from baseline associated with infusion of 50 mg ranitidine over a 5‐minute period. The different chemical ring structure of ranitidine and its effect on H2 vascular and cardiac receptors may account for these observations.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1988.tb05722.x</identifier><identifier>PMID: 3243926</identifier><identifier>CODEN: JCPCBR</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Critical Care ; Double-Blind Method ; Drug toxicity and drugs side effects treatment ; Female ; Hemodynamics - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Postoperative Period ; Ranitidine - pharmacology ; Toxicity: cardiovascular system</subject><ispartof>Journal of clinical pharmacology, 1988-12, Vol.28 (12), p.1098-1100</ispartof><rights>1988 American College of Clinical Pharmacology</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4382-2d40258c9f2ee881dfbd025b3b7525ce686e64816f54f57968199300e2f84df53</citedby><cites>FETCH-LOGICAL-c4382-2d40258c9f2ee881dfbd025b3b7525ce686e64816f54f57968199300e2f84df53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1552-4604.1988.tb05722.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1552-4604.1988.tb05722.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6695068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3243926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onofrey, David</creatorcontrib><creatorcontrib>Kelly, Kathleen M.</creatorcontrib><creatorcontrib>Gentili, David R.</creatorcontrib><creatorcontrib>Benjamin, Ernest</creatorcontrib><creatorcontrib>Iberti, Thomas J.</creatorcontrib><title>The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double-Blind Prospective Study</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>The hemodynamic effects of intravenous ranitidine were studied in a prospective double‐blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found no statistically significant hemodynamic changes from baseline associated with infusion of 50 mg ranitidine over a 5‐minute period. The different chemical ring structure of ranitidine and its effect on H2 vascular and cardiac receptors may account for these observations.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Critical Care</subject><subject>Double-Blind Method</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Ranitidine - pharmacology</subject><subject>Toxicity: cardiovascular system</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEFv1DAQhS0EKkvhJyBZCHFLsJ3YcXqiLKVb2MICrThaTjwWXhJniZOy--9xtNHeOY0175vnmYfQK0pSSgh7u00p5yzJBclTWkqZDhXhBWPp_hFanKTHaEFISRNWEPIUPQthSwgVOadn6CxjeVYysUDh7hfgFbSdOXjduhpfWQv1EHBn8Y0fev0AvhsD_q69G5xxHrDzkwI-uAfAS90Dvo8a3ujBgR_CBb7EH7qxaiB53zhv8Kbvwi56TviPYTSH5-iJ1U2AF3M9R_cfr-6Wq2T99fpmeblO6jyTLGEmJ4zLurQMQEpqbGVio8qqgjNeg5ACRC6psDy3vCiFpGWZEQLMytxYnp2jN0ffXd_9GSEMqnWhhqbRHuJNqpBFVnDKInhxBOu4aujBql3vWt0fFCVqSlxt1RSrmmJVU-JqTlzt4_DL-ZexasGcRueIo_561nWodWN77WsXTpgQJSdCRuzdEfvrGjj8xwLq03Kzmp7RIjlauDDA_mSh-99KTJeqn1-u1e16xcm3W6Y-Z_8AUP6s3g</recordid><startdate>198812</startdate><enddate>198812</enddate><creator>Onofrey, David</creator><creator>Kelly, Kathleen M.</creator><creator>Gentili, David R.</creator><creator>Benjamin, Ernest</creator><creator>Iberti, Thomas J.</creator><general>Blackwell Publishing Ltd</general><general>Sage Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198812</creationdate><title>The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double-Blind Prospective Study</title><author>Onofrey, David ; Kelly, Kathleen M. ; Gentili, David R. ; Benjamin, Ernest ; Iberti, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4382-2d40258c9f2ee881dfbd025b3b7525ce686e64816f54f57968199300e2f84df53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Critical Care</topic><topic>Double-Blind Method</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Ranitidine - pharmacology</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onofrey, David</creatorcontrib><creatorcontrib>Kelly, Kathleen M.</creatorcontrib><creatorcontrib>Gentili, David R.</creatorcontrib><creatorcontrib>Benjamin, Ernest</creatorcontrib><creatorcontrib>Iberti, Thomas J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onofrey, David</au><au>Kelly, Kathleen M.</au><au>Gentili, David R.</au><au>Benjamin, Ernest</au><au>Iberti, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double-Blind Prospective Study</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1988-12</date><risdate>1988</risdate><volume>28</volume><issue>12</issue><spage>1098</spage><epage>1100</epage><pages>1098-1100</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><coden>JCPCBR</coden><abstract>The hemodynamic effects of intravenous ranitidine were studied in a prospective double‐blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found no statistically significant hemodynamic changes from baseline associated with infusion of 50 mg ranitidine over a 5‐minute period. The different chemical ring structure of ranitidine and its effect on H2 vascular and cardiac receptors may account for these observations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3243926</pmid><doi>10.1002/j.1552-4604.1988.tb05722.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2700 |
| ispartof | Journal of clinical pharmacology, 1988-12, Vol.28 (12), p.1098-1100 |
| issn | 0091-2700 1552-4604 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78737512 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Critical Care Double-Blind Method Drug toxicity and drugs side effects treatment Female Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Postoperative Period Ranitidine - pharmacology Toxicity: cardiovascular system |
| title | The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double-Blind Prospective Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T19%3A31%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Hemodynamic%20Effects%20of%20Intravenous%20Ranitidine%20in%20Intensive%20Care%20Unit%20Patients:%20A%20Double-Blind%20Prospective%20Study&rft.jtitle=Journal%20of%20clinical%20pharmacology&rft.au=Onofrey,%20David&rft.date=1988-12&rft.volume=28&rft.issue=12&rft.spage=1098&rft.epage=1100&rft.pages=1098-1100&rft.issn=0091-2700&rft.eissn=1552-4604&rft.coden=JCPCBR&rft_id=info:doi/10.1002/j.1552-4604.1988.tb05722.x&rft_dat=%3Cproquest_cross%3E78737512%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78737512&rft_id=info:pmid/3243926&rfr_iscdi=true |