How does xenon produce anaesthesia?
Since the discovery that the gas xenon can produce general anaesthesia without causing undesirable side effects, we have remained surprisingly ignorant of the molecular mechanisms underlying this clinical activity of an 'inert' gas. Although most general anaesthetics enhance the activity o...
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| Veröffentlicht in: | Nature (London) 1998-11, Vol.396 (6709), p.324-324 |
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| creator | Franks, N. P Dickinson, R de Sousa, S. L. M Hall, A. C Lieb, W. R |
| description | Since the discovery that the gas xenon can produce general anaesthesia without causing undesirable side effects, we have remained surprisingly ignorant of the molecular mechanisms underlying this clinical activity of an 'inert' gas. Although most general anaesthetics enhance the activity of inhibitory GABAA (γ-aminobutyric acid type-A) receptors,, we find that the effects of xenon on these receptors are negligible. Instead, xenon potently inhibits the excitatory NMDA (N-methyl-D-aspartate) receptor channels, which may account for many of xenon's attractive pharmacological properties. |
| doi_str_mv | 10.1038/24525 |
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| subjects | 2-Amino-5-phosphonovalerate - pharmacology Anaesthesia Anaesthetics Anesthesia Anesthetics, Inhalation - pharmacology Animals Cells, Cultured Channels Electrophysiology Excitation Excitatory Amino Acid Antagonists - pharmacology Hippocampus - cytology Hippocampus - drug effects Humanities and Social Sciences Humans Inert multidisciplinary Neurons Rats Receptors Receptors, GABA-A - drug effects Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Science Science (multidisciplinary) scientific-correspondence Side effects Synaptic Transmission - drug effects Xenon Xenon - pharmacology |
| title | How does xenon produce anaesthesia? |
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