Effect of profound ischaemia on human muscle: MRI, phosphorus MRS and near-infrared studies
A pressure cuff was applied to the legs of two human volunteers in order to stop any blood supply for a period of about 30 min. The affected muscle was monitored using proton magnetic resonance imaging (MRI), phosphorus magnetic resonance spectrometry (MRS) and near infrared (NIR) specroscopy before...
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| Veröffentlicht in: | NMR in biomedicine 1996-10, Vol.9 (7), p.305-314 |
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| container_title | NMR in biomedicine |
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| creator | Hajnal, Joseph V. Roberts, Idris Wilson, Jason Oatridge, Angela Saeed, Nadeem Cox, I. Jane Ala-Korpela, Mika Bydder, Graeme M. Young, Ian R. |
| description | A pressure cuff was applied to the legs of two human volunteers in order to stop any blood supply for a period of about 30 min. The affected muscle was monitored using proton magnetic resonance imaging (MRI), phosphorus magnetic resonance spectrometry (MRS) and near infrared (NIR) specroscopy before, during and after this procedure. The internal temperature of the tissue was also measured. The phase of water protons in muscle showed changes that were not accounted for by the measured temperature, but which correlated with the large increase in deoxyhaemoglobin and deoxymyoglobin observed with NIR as well as the decrease in PCr and increase in Pi observed with MRS. Little or no change was found in proton density or T2*. These results show that in vivo measurements of temperature using the chemical shift method may be confounded by changes in tissue oxygenation. They also show that T2* is an insensitive measure of changes in tissue oxygenation. © 1996 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1099-1492(199610)9:7<305::AID-NBM434>3.0.CO;2-D |
| format | Article |
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Little or no change was found in proton density or T2*. These results show that in vivo measurements of temperature using the chemical shift method may be confounded by changes in tissue oxygenation. They also show that T2* is an insensitive measure of changes in tissue oxygenation. © 1996 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0952-3480</identifier><identifier>EISSN: 1099-1492</identifier><identifier>DOI: 10.1002/(SICI)1099-1492(199610)9:7<305::AID-NBM434>3.0.CO;2-D</identifier><identifier>PMID: 9134541</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; Constriction ; Hemoglobins - analysis ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Ischemia - metabolism ; Ischemia - pathology ; Leg - blood supply ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Middle Aged ; Muscle, Skeletal - blood supply ; Myoglobin - analogs & derivatives ; Myoglobin - analysis ; Osteoarticular system. Muscles ; Phosphocreatine - analysis ; Phosphorus ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Reference Values ; Spectrophotometry, Infrared ; Temperature</subject><ispartof>NMR in biomedicine, 1996-10, Vol.9 (7), p.305-314</ispartof><rights>Copyright © 1996 John Wiley & Sons, Ltd.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4314-1c9cbc036fbdbd9d7796fa36d920957d991c83143b3bdebafae7606c07f24fd33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291099-1492%28199610%299%3A7%3C305%3A%3AAID-NBM434%3E3.0.CO%3B2-D$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291099-1492%28199610%299%3A7%3C305%3A%3AAID-NBM434%3E3.0.CO%3B2-D$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2642850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9134541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hajnal, Joseph V.</creatorcontrib><creatorcontrib>Roberts, Idris</creatorcontrib><creatorcontrib>Wilson, Jason</creatorcontrib><creatorcontrib>Oatridge, Angela</creatorcontrib><creatorcontrib>Saeed, Nadeem</creatorcontrib><creatorcontrib>Cox, I. Jane</creatorcontrib><creatorcontrib>Ala-Korpela, Mika</creatorcontrib><creatorcontrib>Bydder, Graeme M.</creatorcontrib><creatorcontrib>Young, Ian R.</creatorcontrib><title>Effect of profound ischaemia on human muscle: MRI, phosphorus MRS and near-infrared studies</title><title>NMR in biomedicine</title><addtitle>NMR Biomed</addtitle><description>A pressure cuff was applied to the legs of two human volunteers in order to stop any blood supply for a period of about 30 min. The affected muscle was monitored using proton magnetic resonance imaging (MRI), phosphorus magnetic resonance spectrometry (MRS) and near infrared (NIR) specroscopy before, during and after this procedure. The internal temperature of the tissue was also measured. The phase of water protons in muscle showed changes that were not accounted for by the measured temperature, but which correlated with the large increase in deoxyhaemoglobin and deoxymyoglobin observed with NIR as well as the decrease in PCr and increase in Pi observed with MRS. Little or no change was found in proton density or T2*. These results show that in vivo measurements of temperature using the chemical shift method may be confounded by changes in tissue oxygenation. They also show that T2* is an insensitive measure of changes in tissue oxygenation. © 1996 John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Constriction</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Ischemia - metabolism</subject><subject>Ischemia - pathology</subject><subject>Leg - blood supply</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Myoglobin - analogs & derivatives</subject><subject>Myoglobin - analysis</subject><subject>Osteoarticular system. Muscles</subject><subject>Phosphocreatine - analysis</subject><subject>Phosphorus</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reference Values</subject><subject>Spectrophotometry, Infrared</subject><subject>Temperature</subject><issn>0952-3480</issn><issn>1099-1492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtv1DAQhS0EKkvhJyD5AaFWIosdO_F6C0glW9pA25VaUCV4GDm-aAO5LPFG0H-PV4nyAuJhZI3nzNGZD6G3lMwpIfHro9s8y48pkTKiXMZHVMqUkmO5FG8YSZbL03wVXb-_4oy_Y3Myz9YncbR6gGbTxkM0IzKJI8YX5DF64v13QsiCs_gAHUjKeMLpDH07c87qHW4d3nata_vG4NLrjbJ1qXDb4E1fqwbXvdeVXeKrm_wV3m5aH6rrfehvsQorjVVdVDauU5012O96U1r_FD1yqvL22fgeoi8fzj5nF9Hl-jzPTi8jzRnlEdVSF5qw1BWmMNIIIVOnWGpkHPILIyXViyBkBSuMLZRTVqQk1US4mDvD2CF6OfiGC3721u-gDifYqlKNbXsPYiEYkVyyKYDuWu8762DblbXq7oES2EMH2EOHPULYI4QBOkgQEKADBOgwQAcGBLI1xLAKvs_HAH1RWzO5jpTD_MU4V16rKlBqdOknWZzyeJGQILsbZL_Kyt7_le3_0f6ZbPwJztHgXPqd_T05q-4HpIKJBO6uz0FeZOlH-fUGPrE_HXi4hw</recordid><startdate>199610</startdate><enddate>199610</enddate><creator>Hajnal, Joseph V.</creator><creator>Roberts, Idris</creator><creator>Wilson, Jason</creator><creator>Oatridge, Angela</creator><creator>Saeed, Nadeem</creator><creator>Cox, I. Jane</creator><creator>Ala-Korpela, Mika</creator><creator>Bydder, Graeme M.</creator><creator>Young, Ian R.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199610</creationdate><title>Effect of profound ischaemia on human muscle: MRI, phosphorus MRS and near-infrared studies</title><author>Hajnal, Joseph V. ; Roberts, Idris ; Wilson, Jason ; Oatridge, Angela ; Saeed, Nadeem ; Cox, I. Jane ; Ala-Korpela, Mika ; Bydder, Graeme M. ; Young, Ian R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4314-1c9cbc036fbdbd9d7796fa36d920957d991c83143b3bdebafae7606c07f24fd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Constriction</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Ischemia - metabolism</topic><topic>Ischemia - pathology</topic><topic>Leg - blood supply</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Myoglobin - analogs & derivatives</topic><topic>Myoglobin - analysis</topic><topic>Osteoarticular system. Muscles</topic><topic>Phosphocreatine - analysis</topic><topic>Phosphorus</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reference Values</topic><topic>Spectrophotometry, Infrared</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hajnal, Joseph V.</creatorcontrib><creatorcontrib>Roberts, Idris</creatorcontrib><creatorcontrib>Wilson, Jason</creatorcontrib><creatorcontrib>Oatridge, Angela</creatorcontrib><creatorcontrib>Saeed, Nadeem</creatorcontrib><creatorcontrib>Cox, I. 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Jane</au><au>Ala-Korpela, Mika</au><au>Bydder, Graeme M.</au><au>Young, Ian R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of profound ischaemia on human muscle: MRI, phosphorus MRS and near-infrared studies</atitle><jtitle>NMR in biomedicine</jtitle><addtitle>NMR Biomed</addtitle><date>1996-10</date><risdate>1996</risdate><volume>9</volume><issue>7</issue><spage>305</spage><epage>314</epage><pages>305-314</pages><issn>0952-3480</issn><eissn>1099-1492</eissn><abstract>A pressure cuff was applied to the legs of two human volunteers in order to stop any blood supply for a period of about 30 min. The affected muscle was monitored using proton magnetic resonance imaging (MRI), phosphorus magnetic resonance spectrometry (MRS) and near infrared (NIR) specroscopy before, during and after this procedure. The internal temperature of the tissue was also measured. The phase of water protons in muscle showed changes that were not accounted for by the measured temperature, but which correlated with the large increase in deoxyhaemoglobin and deoxymyoglobin observed with NIR as well as the decrease in PCr and increase in Pi observed with MRS. Little or no change was found in proton density or T2*. These results show that in vivo measurements of temperature using the chemical shift method may be confounded by changes in tissue oxygenation. They also show that T2* is an insensitive measure of changes in tissue oxygenation. © 1996 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>9134541</pmid><doi>10.1002/(SICI)1099-1492(199610)9:7<305::AID-NBM434>3.0.CO;2-D</doi><tpages>10</tpages></addata></record> |
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| ispartof | NMR in biomedicine, 1996-10, Vol.9 (7), p.305-314 |
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| language | eng |
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| source | Wiley Online Library Journals【Remote access available】; MEDLINE |
| subjects | Biological and medical sciences Constriction Hemoglobins - analysis Humans Investigative techniques, diagnostic techniques (general aspects) Ischemia - metabolism Ischemia - pathology Leg - blood supply Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged Muscle, Skeletal - blood supply Myoglobin - analogs & derivatives Myoglobin - analysis Osteoarticular system. Muscles Phosphocreatine - analysis Phosphorus Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values Spectrophotometry, Infrared Temperature |
| title | Effect of profound ischaemia on human muscle: MRI, phosphorus MRS and near-infrared studies |
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