Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats
Alterations in cellular calcium metabolism in essential hypertensive and in the SHR have been described. In the present study, particle-induced X-ray emission (PIXE) was used to get some information on the spatial distribution of Ca2+ in aortas of spontaneously hypertensive rats (SHR) and normotensi...
Gespeichert in:
| Veröffentlicht in: | Research in experimental medicine 1988-01, Vol.188 (6), p.397-403 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 403 |
|---|---|
| container_issue | 6 |
| container_start_page | 397 |
| container_title | Research in experimental medicine |
| container_volume | 188 |
| creator | SPIEKER, C ZIDEK, W VON BASSEWITZ, D. B HECK, D |
| description | Alterations in cellular calcium metabolism in essential hypertensive and in the SHR have been described. In the present study, particle-induced X-ray emission (PIXE) was used to get some information on the spatial distribution of Ca2+ in aortas of spontaneously hypertensive rats (SHR) and normotensive controls aged 1 week, 4 weeks, and 12 weeks. It was found that the Ca2+ content was not elevated in the aortic smooth muscle of SHR aged 1 week (n = 9) as compared to normotensive controls (n = 8) (186.8 +/- 89.9 micrograms Ca2+/g tissue vs 254.0 +/- 73.7 micrograms Ca2+/g tissue. The Ca2+ content was significantly raised in the aortic smooth muscle of SHR aged 4 weeks (n = 9) as compared to 4-weeks-old WKY rats (n = 12) (726.0 +/- 130.4 Ca2+/g tissue vs 440.3 +/- 214.4 Ca2+ micrograms/g tissue and in SHR aged 3 months (n = 15) as compared to WKY rats (n = 12), respectively (3317.0 +/- 734.0 micrograms Ca2+/g tissue vs. 1632.0 +/- 569.6 micrograms Ca2+/g tissue). The results confirm the age-related increase in the arterial Ca2+ content in normotensive rats and demonstrate additionally that this age-related rise in arterial Ca2+ content is accelerated in SHR. |
| doi_str_mv | 10.1007/BF01851997 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78725320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78725320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-bad77915114b76e2caa1dc8627af069a56078bf11d6fa4d8e00ca787079e63fa3</originalsourceid><addsrcrecordid>eNqFkD1LxEAQhhdRzvOjsRdSiIUQnckmu9nyFE8FwUYrizDZTLxIvtxNhPv35rhDS6sZeJ95GR4hzhCuEUDf3C4B0wSN0XtijrGUYZqksC_mIAFCgxIOxZH3nwColcaZmMlIpqjjuXhffHBYcM9twe0QVK11TJ6nJSA3sKuoDnzTdcMqaEZvaw4s1bYamw3h-64dqOVu9PU6WK17nk5aX31z4GjwJ-KgpNrz6W4ei7fl_evdY_j88vB0t3gOrYyjIcyp0NpgghjnWnFkibCwqYo0laAMJQp0mpeIhSopLlIGsKRTDdqwkiXJY3G57e1d9zWyH7Km8pbrevtaNrFRIiP4F8REaki0mcCrLWhd573jMutd1ZBbZwjZRnn2p3yCz3etY95w8YvuHE_5xS4nP8krHbW28r-YMsbERskfJC2JCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15370579</pqid></control><display><type>article</type><title>Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>SPIEKER, C ; ZIDEK, W ; VON BASSEWITZ, D. B ; HECK, D</creator><creatorcontrib>SPIEKER, C ; ZIDEK, W ; VON BASSEWITZ, D. B ; HECK, D</creatorcontrib><description>Alterations in cellular calcium metabolism in essential hypertensive and in the SHR have been described. In the present study, particle-induced X-ray emission (PIXE) was used to get some information on the spatial distribution of Ca2+ in aortas of spontaneously hypertensive rats (SHR) and normotensive controls aged 1 week, 4 weeks, and 12 weeks. It was found that the Ca2+ content was not elevated in the aortic smooth muscle of SHR aged 1 week (n = 9) as compared to normotensive controls (n = 8) (186.8 +/- 89.9 micrograms Ca2+/g tissue vs 254.0 +/- 73.7 micrograms Ca2+/g tissue. The Ca2+ content was significantly raised in the aortic smooth muscle of SHR aged 4 weeks (n = 9) as compared to 4-weeks-old WKY rats (n = 12) (726.0 +/- 130.4 Ca2+/g tissue vs 440.3 +/- 214.4 Ca2+ micrograms/g tissue and in SHR aged 3 months (n = 15) as compared to WKY rats (n = 12), respectively (3317.0 +/- 734.0 micrograms Ca2+/g tissue vs. 1632.0 +/- 569.6 micrograms Ca2+/g tissue). The results confirm the age-related increase in the arterial Ca2+ content in normotensive rats and demonstrate additionally that this age-related rise in arterial Ca2+ content is accelerated in SHR.</description><identifier>ISSN: 0300-9130</identifier><identifier>EISSN: 1433-8580</identifier><identifier>DOI: 10.1007/BF01851997</identifier><identifier>PMID: 3238174</identifier><identifier>CODEN: REXMAS</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aging - metabolism ; Animals ; Aorta - metabolism ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Calcium - analysis ; Calcium - metabolism ; Cardiology. Vascular system ; Experimental diseases ; Hypertension - metabolism ; Medical sciences ; Muscle, Smooth, Vascular - diagnostic imaging ; Muscle, Smooth, Vascular - metabolism ; Radiography ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Spectrometry, X-Ray Emission</subject><ispartof>Research in experimental medicine, 1988-01, Vol.188 (6), p.397-403</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-bad77915114b76e2caa1dc8627af069a56078bf11d6fa4d8e00ca787079e63fa3</citedby><cites>FETCH-LOGICAL-c342t-bad77915114b76e2caa1dc8627af069a56078bf11d6fa4d8e00ca787079e63fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6999496$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3238174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SPIEKER, C</creatorcontrib><creatorcontrib>ZIDEK, W</creatorcontrib><creatorcontrib>VON BASSEWITZ, D. B</creatorcontrib><creatorcontrib>HECK, D</creatorcontrib><title>Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats</title><title>Research in experimental medicine</title><addtitle>Res Exp Med (Berl)</addtitle><description>Alterations in cellular calcium metabolism in essential hypertensive and in the SHR have been described. In the present study, particle-induced X-ray emission (PIXE) was used to get some information on the spatial distribution of Ca2+ in aortas of spontaneously hypertensive rats (SHR) and normotensive controls aged 1 week, 4 weeks, and 12 weeks. It was found that the Ca2+ content was not elevated in the aortic smooth muscle of SHR aged 1 week (n = 9) as compared to normotensive controls (n = 8) (186.8 +/- 89.9 micrograms Ca2+/g tissue vs 254.0 +/- 73.7 micrograms Ca2+/g tissue. The Ca2+ content was significantly raised in the aortic smooth muscle of SHR aged 4 weeks (n = 9) as compared to 4-weeks-old WKY rats (n = 12) (726.0 +/- 130.4 Ca2+/g tissue vs 440.3 +/- 214.4 Ca2+ micrograms/g tissue and in SHR aged 3 months (n = 15) as compared to WKY rats (n = 12), respectively (3317.0 +/- 734.0 micrograms Ca2+/g tissue vs. 1632.0 +/- 569.6 micrograms Ca2+/g tissue). The results confirm the age-related increase in the arterial Ca2+ content in normotensive rats and demonstrate additionally that this age-related rise in arterial Ca2+ content is accelerated in SHR.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Aorta - metabolism</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Calcium - analysis</subject><subject>Calcium - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Experimental diseases</subject><subject>Hypertension - metabolism</subject><subject>Medical sciences</subject><subject>Muscle, Smooth, Vascular - diagnostic imaging</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Spectrometry, X-Ray Emission</subject><issn>0300-9130</issn><issn>1433-8580</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1LxEAQhhdRzvOjsRdSiIUQnckmu9nyFE8FwUYrizDZTLxIvtxNhPv35rhDS6sZeJ95GR4hzhCuEUDf3C4B0wSN0XtijrGUYZqksC_mIAFCgxIOxZH3nwColcaZmMlIpqjjuXhffHBYcM9twe0QVK11TJ6nJSA3sKuoDnzTdcMqaEZvaw4s1bYamw3h-64dqOVu9PU6WK17nk5aX31z4GjwJ-KgpNrz6W4ei7fl_evdY_j88vB0t3gOrYyjIcyp0NpgghjnWnFkibCwqYo0laAMJQp0mpeIhSopLlIGsKRTDdqwkiXJY3G57e1d9zWyH7Km8pbrevtaNrFRIiP4F8REaki0mcCrLWhd573jMutd1ZBbZwjZRnn2p3yCz3etY95w8YvuHE_5xS4nP8krHbW28r-YMsbERskfJC2JCw</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>SPIEKER, C</creator><creator>ZIDEK, W</creator><creator>VON BASSEWITZ, D. B</creator><creator>HECK, D</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats</title><author>SPIEKER, C ; ZIDEK, W ; VON BASSEWITZ, D. B ; HECK, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-bad77915114b76e2caa1dc8627af069a56078bf11d6fa4d8e00ca787079e63fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Aorta - metabolism</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Calcium - analysis</topic><topic>Calcium - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Experimental diseases</topic><topic>Hypertension - metabolism</topic><topic>Medical sciences</topic><topic>Muscle, Smooth, Vascular - diagnostic imaging</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Spectrometry, X-Ray Emission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SPIEKER, C</creatorcontrib><creatorcontrib>ZIDEK, W</creatorcontrib><creatorcontrib>VON BASSEWITZ, D. B</creatorcontrib><creatorcontrib>HECK, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SPIEKER, C</au><au>ZIDEK, W</au><au>VON BASSEWITZ, D. B</au><au>HECK, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats</atitle><jtitle>Research in experimental medicine</jtitle><addtitle>Res Exp Med (Berl)</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>188</volume><issue>6</issue><spage>397</spage><epage>403</epage><pages>397-403</pages><issn>0300-9130</issn><eissn>1433-8580</eissn><coden>REXMAS</coden><abstract>Alterations in cellular calcium metabolism in essential hypertensive and in the SHR have been described. In the present study, particle-induced X-ray emission (PIXE) was used to get some information on the spatial distribution of Ca2+ in aortas of spontaneously hypertensive rats (SHR) and normotensive controls aged 1 week, 4 weeks, and 12 weeks. It was found that the Ca2+ content was not elevated in the aortic smooth muscle of SHR aged 1 week (n = 9) as compared to normotensive controls (n = 8) (186.8 +/- 89.9 micrograms Ca2+/g tissue vs 254.0 +/- 73.7 micrograms Ca2+/g tissue. The Ca2+ content was significantly raised in the aortic smooth muscle of SHR aged 4 weeks (n = 9) as compared to 4-weeks-old WKY rats (n = 12) (726.0 +/- 130.4 Ca2+/g tissue vs 440.3 +/- 214.4 Ca2+ micrograms/g tissue and in SHR aged 3 months (n = 15) as compared to WKY rats (n = 12), respectively (3317.0 +/- 734.0 micrograms Ca2+/g tissue vs. 1632.0 +/- 569.6 micrograms Ca2+/g tissue). The results confirm the age-related increase in the arterial Ca2+ content in normotensive rats and demonstrate additionally that this age-related rise in arterial Ca2+ content is accelerated in SHR.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3238174</pmid><doi>10.1007/BF01851997</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9130 |
| ispartof | Research in experimental medicine, 1988-01, Vol.188 (6), p.397-403 |
| issn | 0300-9130 1433-8580 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78725320 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aging - metabolism Animals Aorta - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Calcium - analysis Calcium - metabolism Cardiology. Vascular system Experimental diseases Hypertension - metabolism Medical sciences Muscle, Smooth, Vascular - diagnostic imaging Muscle, Smooth, Vascular - metabolism Radiography Rats Rats, Inbred SHR Rats, Inbred WKY Spectrometry, X-Ray Emission |
| title | Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A48%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-dependent%20increase%20in%20arterial%20smooth%20muscle%20calcium%20in%20spontaneously%20hypertensive%20rats&rft.jtitle=Research%20in%20experimental%20medicine&rft.au=SPIEKER,%20C&rft.date=1988-01-01&rft.volume=188&rft.issue=6&rft.spage=397&rft.epage=403&rft.pages=397-403&rft.issn=0300-9130&rft.eissn=1433-8580&rft.coden=REXMAS&rft_id=info:doi/10.1007/BF01851997&rft_dat=%3Cproquest_cross%3E78725320%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15370579&rft_id=info:pmid/3238174&rfr_iscdi=true |