In vitro antibiotic sensitivity pattern of common bacterial isolates from cases of acute bacterial meningitis with special reference to ceftriaxone
Ceftriaxone (RO 13-9904) has only recently been introduced in Benghazi and many parts of the word. We determined its in-vitro antibacterial activity against the primary aetiological agents of childhood meningitis in Benghazi, that included eighteen (23.3%) strains of H. influenzae, 17 (22.1%) of Str...
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| Veröffentlicht in: | Indian journal of pediatrics 1997-11, Vol.64 (6), p.849-854 |
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| creator | BANDARU NARASINGA RAO IBRAHIM MAHDI KASHBUR EL SHEMBESH, N. M SULIMAN MOHAMED BARGATHY |
| description | Ceftriaxone (RO 13-9904) has only recently been introduced in Benghazi and many parts of the word. We determined its in-vitro antibacterial activity against the primary aetiological agents of childhood meningitis in Benghazi, that included eighteen (23.3%) strains of H. influenzae, 17 (22.1%) of Str. pneumoniae and 1 (1.3%) of N. meningitidis isolated from 77 cases of acute purulent meningitis above the age of neonatal period. All strains of H. influenzae. Str. pneumoniae and N. meningitidis were sensitive to ceftriaxone and showed wide zones of inhibition by the disc diffusion technique of Kirby-Bauer. Ampicillin and chloramphenicol resistance was observed for H. influenzae (23% and 11% respectively), and Str. pneumoniae (12% and 0% respectively), in addition, 18% of strains of Str. pneumoniae showed resistance to penicillin. The broad spectrum activity of ceftriaxone has been confirmed for our locality and this finding, together with its exceptionally long half-life, excellent penetration into the C.S.F. and ease of administration (single daily dose) warrants it as the drug of choice in empherical treatment of cases of acute bacterial meningitis in children in Benghazi and in cases where resistance to ampicillin and chloramphenicol are found on subsequent testing. |
| doi_str_mv | 10.1007/BF02725510 |
| format | Article |
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M ; SULIMAN MOHAMED BARGATHY</creator><creatorcontrib>BANDARU NARASINGA RAO ; IBRAHIM MAHDI KASHBUR ; EL SHEMBESH, N. M ; SULIMAN MOHAMED BARGATHY</creatorcontrib><description>Ceftriaxone (RO 13-9904) has only recently been introduced in Benghazi and many parts of the word. We determined its in-vitro antibacterial activity against the primary aetiological agents of childhood meningitis in Benghazi, that included eighteen (23.3%) strains of H. influenzae, 17 (22.1%) of Str. pneumoniae and 1 (1.3%) of N. meningitidis isolated from 77 cases of acute purulent meningitis above the age of neonatal period. All strains of H. influenzae. Str. pneumoniae and N. meningitidis were sensitive to ceftriaxone and showed wide zones of inhibition by the disc diffusion technique of Kirby-Bauer. Ampicillin and chloramphenicol resistance was observed for H. influenzae (23% and 11% respectively), and Str. pneumoniae (12% and 0% respectively), in addition, 18% of strains of Str. pneumoniae showed resistance to penicillin. The broad spectrum activity of ceftriaxone has been confirmed for our locality and this finding, together with its exceptionally long half-life, excellent penetration into the C.S.F. and ease of administration (single daily dose) warrants it as the drug of choice in empherical treatment of cases of acute bacterial meningitis in children in Benghazi and in cases where resistance to ampicillin and chloramphenicol are found on subsequent testing.</description><identifier>ISSN: 0019-5456</identifier><identifier>EISSN: 0973-7693</identifier><identifier>DOI: 10.1007/BF02725510</identifier><identifier>PMID: 10771929</identifier><identifier>CODEN: IJPEA2</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Acute Disease ; Anti-Bacterial Agents - pharmacology ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Ceftriaxone - pharmacology ; Cephalosporins - pharmacology ; Child ; Child, Preschool ; Female ; Gram-Negative Bacteria - drug effects ; Gram-Negative Bacteria - isolation & purification ; Gram-Positive Bacteria - drug effects ; Gram-Positive Bacteria - isolation & purification ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Libya ; Male ; Medical sciences ; Meningitis, Bacterial - drug therapy ; Meningitis, Bacterial - microbiology ; Microbial Sensitivity Tests ; Sensitivity and Specificity ; Tropical medicine</subject><ispartof>Indian journal of pediatrics, 1997-11, Vol.64 (6), p.849-854</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c227t-d5765bdf9839a40d705d1984d07be927d8d0c24463419f7bdb6b093333b358973</citedby><cites>FETCH-LOGICAL-c227t-d5765bdf9839a40d705d1984d07be927d8d0c24463419f7bdb6b093333b358973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2087267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10771929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANDARU NARASINGA RAO</creatorcontrib><creatorcontrib>IBRAHIM MAHDI KASHBUR</creatorcontrib><creatorcontrib>EL SHEMBESH, N. M</creatorcontrib><creatorcontrib>SULIMAN MOHAMED BARGATHY</creatorcontrib><title>In vitro antibiotic sensitivity pattern of common bacterial isolates from cases of acute bacterial meningitis with special reference to ceftriaxone</title><title>Indian journal of pediatrics</title><addtitle>Indian J Pediatr</addtitle><description>Ceftriaxone (RO 13-9904) has only recently been introduced in Benghazi and many parts of the word. We determined its in-vitro antibacterial activity against the primary aetiological agents of childhood meningitis in Benghazi, that included eighteen (23.3%) strains of H. influenzae, 17 (22.1%) of Str. pneumoniae and 1 (1.3%) of N. meningitidis isolated from 77 cases of acute purulent meningitis above the age of neonatal period. All strains of H. influenzae. Str. pneumoniae and N. meningitidis were sensitive to ceftriaxone and showed wide zones of inhibition by the disc diffusion technique of Kirby-Bauer. Ampicillin and chloramphenicol resistance was observed for H. influenzae (23% and 11% respectively), and Str. pneumoniae (12% and 0% respectively), in addition, 18% of strains of Str. pneumoniae showed resistance to penicillin. The broad spectrum activity of ceftriaxone has been confirmed for our locality and this finding, together with its exceptionally long half-life, excellent penetration into the C.S.F. and ease of administration (single daily dose) warrants it as the drug of choice in empherical treatment of cases of acute bacterial meningitis in children in Benghazi and in cases where resistance to ampicillin and chloramphenicol are found on subsequent testing.</description><subject>Acute Disease</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Ceftriaxone - pharmacology</subject><subject>Cephalosporins - pharmacology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Negative Bacteria - isolation & purification</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - isolation & purification</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Libya</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis, Bacterial - drug therapy</subject><subject>Meningitis, Bacterial - microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Sensitivity and Specificity</subject><subject>Tropical medicine</subject><issn>0019-5456</issn><issn>0973-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0cuKFTEQBuAginPRjQ8gWYgLobWSdHc6S2dwxoEBN7pucqnWSHdyTOWo8xy-sBnOQSebFD8flVDF2AsBbwWAfndxBVLLYRDwiJ2C0arTo1GPWw3CdEM_jCfsjOg7gDQwmqfsRIDWwkhzyv7cJP4z1pK5TTW6mGv0nDBRrLHld3xna8WSeF64z9uWE3fWtyTalUfKq61IfCl5495SK5uzfl_xAdswxfS1NST-K9ZvnHbo7_OCCxZMHnnN3ONSm_6dEz5jTxa7Ej4_3ufsy9WHz5cfu9tP1zeX7287L6WuXRj0OLiwmEkZ20PQMARhpj6AdmikDlMAL_t-VL0wi3bBjQ6MasepYWpjOmevD313Jf_YI9V5i-RxXW3CvKdZT1r2SskG3xygL5mofXvelbjZcjcLmO9XMP9fQcMvj133bsPwgB5m3sCrI7Dk7boUm3ykf05Ce3bU6i-EwpA1</recordid><startdate>199711</startdate><enddate>199711</enddate><creator>BANDARU NARASINGA RAO</creator><creator>IBRAHIM MAHDI KASHBUR</creator><creator>EL SHEMBESH, N. M</creator><creator>SULIMAN MOHAMED BARGATHY</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199711</creationdate><title>In vitro antibiotic sensitivity pattern of common bacterial isolates from cases of acute bacterial meningitis with special reference to ceftriaxone</title><author>BANDARU NARASINGA RAO ; IBRAHIM MAHDI KASHBUR ; EL SHEMBESH, N. M ; SULIMAN MOHAMED BARGATHY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c227t-d5765bdf9839a40d705d1984d07be927d8d0c24463419f7bdb6b093333b358973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute Disease</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Ceftriaxone - pharmacology</topic><topic>Cephalosporins - pharmacology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Negative Bacteria - isolation & purification</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - isolation & purification</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Libya</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meningitis, Bacterial - drug therapy</topic><topic>Meningitis, Bacterial - microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Sensitivity and Specificity</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BANDARU NARASINGA RAO</creatorcontrib><creatorcontrib>IBRAHIM MAHDI KASHBUR</creatorcontrib><creatorcontrib>EL SHEMBESH, N. 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M</au><au>SULIMAN MOHAMED BARGATHY</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro antibiotic sensitivity pattern of common bacterial isolates from cases of acute bacterial meningitis with special reference to ceftriaxone</atitle><jtitle>Indian journal of pediatrics</jtitle><addtitle>Indian J Pediatr</addtitle><date>1997-11</date><risdate>1997</risdate><volume>64</volume><issue>6</issue><spage>849</spage><epage>854</epage><pages>849-854</pages><issn>0019-5456</issn><eissn>0973-7693</eissn><coden>IJPEA2</coden><abstract>Ceftriaxone (RO 13-9904) has only recently been introduced in Benghazi and many parts of the word. We determined its in-vitro antibacterial activity against the primary aetiological agents of childhood meningitis in Benghazi, that included eighteen (23.3%) strains of H. influenzae, 17 (22.1%) of Str. pneumoniae and 1 (1.3%) of N. meningitidis isolated from 77 cases of acute purulent meningitis above the age of neonatal period. All strains of H. influenzae. Str. pneumoniae and N. meningitidis were sensitive to ceftriaxone and showed wide zones of inhibition by the disc diffusion technique of Kirby-Bauer. Ampicillin and chloramphenicol resistance was observed for H. influenzae (23% and 11% respectively), and Str. pneumoniae (12% and 0% respectively), in addition, 18% of strains of Str. pneumoniae showed resistance to penicillin. The broad spectrum activity of ceftriaxone has been confirmed for our locality and this finding, together with its exceptionally long half-life, excellent penetration into the C.S.F. and ease of administration (single daily dose) warrants it as the drug of choice in empherical treatment of cases of acute bacterial meningitis in children in Benghazi and in cases where resistance to ampicillin and chloramphenicol are found on subsequent testing.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>10771929</pmid><doi>10.1007/BF02725510</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Disease Anti-Bacterial Agents - pharmacology Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Ceftriaxone - pharmacology Cephalosporins - pharmacology Child Child, Preschool Female Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - isolation & purification Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - isolation & purification Human bacterial diseases Humans Infant Infectious diseases Libya Male Medical sciences Meningitis, Bacterial - drug therapy Meningitis, Bacterial - microbiology Microbial Sensitivity Tests Sensitivity and Specificity Tropical medicine |
| title | In vitro antibiotic sensitivity pattern of common bacterial isolates from cases of acute bacterial meningitis with special reference to ceftriaxone |
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