Chondrotoxicity and toxicokinetics of novel quinolone antibacterial agents DC-159a and DX-619 in juvenile rats

Abstract Quinolone antibacterial agents are extensively utilized in antimicrobial chemotherapy. However, they have been reported to induce arthropathy in juvenile animals, and the mechanism has not been clarified. Recently, we have demonstrated that Dusp1, Tnfrsf12a, Ptgs2, Fos, Mt1a, Plaur, Mmp3, S...

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Veröffentlicht in:	Toxicology (Amsterdam) 2010-10, Vol.276 (2), p.122-127
Hauptverfasser:	Goto, Koichi, Yabe, Koichi, Suzuki, Takami, Jindo, Toshimasa, Sanbuissho, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aminopyridines - administration & dosage Aminopyridines - pharmacokinetics Aminopyridines - toxicity Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - toxicity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Area Under Curve Biological and medical sciences Cartilage, Articular - drug effects Cartilage, Articular - metabolism Chondrotoxicity DC-159a Dose-Response Relationship, Drug DX-619 Emergency Fluoroquinolones - administration & dosage Fluoroquinolones - pharmacokinetics Fluoroquinolones - toxicity Gene Expression Regulation - drug effects Male Medical sciences Ofloxacin Ofloxacin - administration & dosage Ofloxacin - pharmacokinetics Ofloxacin - toxicity Pharmacology. Drug treatments Pyrrolidines - administration & dosage Pyrrolidines - pharmacokinetics Pyrrolidines - toxicity Quinolones - administration & dosage Quinolones - pharmacokinetics Quinolones - toxicity Rats Rats, Sprague-Dawley Real-time RT-PCR Reverse Transcriptase Polymerase Chain Reaction Tissue Distribution Toxicokinetics Toxicology
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