Role of glutathione conjugation in 1-bromobutane-induced hepatotoxicity in mice

Halogenated organic compounds, such as 1-bromobutane (1-BB), have been used as cleaning agents, agents for chemical syntheses, or extraction solvents. In the present study, hepatotoxic effects of 1-BB and its conjugation with glutathione (GSH) were investigated in female BALB/c mice. Animals were tr...

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Veröffentlicht in:	Food and chemical toxicology 2010-10, Vol.48 (10), p.2707-2711
Hauptverfasser:	Lee, Sang Kyu, Lee, Dong Ju, Ko, Gyu Sub, Yoo, Se Hyun, Ha, Hyun Woo, Kang, Mi Jeong, Jeong, Tae Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Bromobutane Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biological and medical sciences Body Weight - drug effects Chemical and Drug Induced Liver Injury - metabolism Chromatography, High Pressure Liquid Conjugation Dose-Response Relationship, Drug Female Glutathione Glutathione - metabolism Hepatotoxicity Hydrocarbons, Brominated - toxicity In vivo Liver - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred ICR Organ Size - drug effects Spectrometry, Mass, Electrospray Ionization Toxicology
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