Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom

BaP1 is a P-I class of Snake Venom Metalloproteinase (SVMP) relevant in the local tissue damage associated with envenomations by Bothrops asper, a medically-important species in Central America and parts of South America. Six monoclonal antibodies (MoAb) against BaP1 (MABaP1) were produced and chara...

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Veröffentlicht in:	Toxicon (Oxford) 2010-11, Vol.56 (6), p.1059-1065
Hauptverfasser:	Fernandes, I., Assumpção, G.G., Silveira, C.R.F., Faquim-Mauro, E.L., Tanjoni, I., Carmona, A.K., Alves, M.F.M., Takehara, H.A., Rucavado, A., Ramos, O.H.P., Moura-da-Silva, A.M., Gutiérrez, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification BaP1 Biological and medical sciences Bothrops - physiology Bothrops asper Colubridae Cross Reactions Crotalid Venoms - antagonists & inhibitors Crotalid Venoms - enzymology Crotalid Venoms - toxicity Edema - chemically induced Edema - prevention & control Elapidae Enzyme-Linked Immunosorbent Assay Epitope Mapping Hemorrhage Hemorrhage - chemically induced Hemorrhage - prevention & control Immunoblotting Immunoglobulins Injections, Intraperitoneal Medical sciences Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - immunology Metalloendopeptidases - toxicity Metalloproteinase Mice Mice, Inbred BALB C Monoclonal antibodies Neutralization Tests Neutralizing antibody Snake venom Toxicology Viperidae
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