Induction of Cyclooxygenase-2 Following Anoxic Stress in Piglet Cerebral Arteries

Objective: Ischemic stress causes damage to cerebrovascular endothelium and alters arteriolar responses to prostanoid-dependent stimuli. However, effects of ischemic stress on cyclooxygenase (COX) levels in endothelium are unclear. We examined the effect of ischemia and reperfusion and asphyxia and...

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Veröffentlicht in:	Microcirculation (New York, N.Y. 1994) N.Y. 1994), 1996-12, Vol.3 (4), p.379-386
Hauptverfasser:	Busija, David W., Thore, Clara, Beasley, Tracy, Bari, Ferenc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal asphyxia Brain Ischemia - enzymology Cerebral Arteries - enzymology cerebral blood vessels Cyclooxygenase 1 Cyclooxygenase 2 endothelium Endothelium, Vascular - enzymology Enzyme Induction Female Fluorescent Antibody Technique, Indirect Hypoxia, Brain - enzymology ischemia Isoenzymes - analysis Isoenzymes - biosynthesis Male Muscle, Smooth, Vascular - enzymology prostaglandin H synthase Prostaglandin-Endoperoxide Synthases - analysis Prostaglandin-Endoperoxide Synthases - biosynthesis Reperfusion Injury Swine
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