Renal Abnormalities in Experimental Models of Hypertension: The SHR Versus the Milan HR
Renal regulation of extracellular fluid volumes via the tubuloglomerular feedback control (TGIF) has been studied in rat experiments. Important modulation of the mechanism was achieved from arterial blood pressure level and extracellular fluid volume via renal interstitial pressure changes. This vol...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1988, Vol.12 (3), p.S27-35 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | G. Persson, A Erik Boberg, Ulf |
| description | Renal regulation of extracellular fluid volumes via the tubuloglomerular feedback control (TGIF) has been studied in rat experiments. Important modulation of the mechanism was achieved from arterial blood pressure level and extracellular fluid volume via renal interstitial pressure changes. This volume-regulating mechanism has been studied in spontaneously hypertensive rats of the Milan strain (MHS) and compared with Milan normotensive rats (MNS). During development of hypertension, the TMG mechanism was highly sensitive and activated to reduce glomerular filtration rate and retain electrolytes and water. When blood pressure was increased in the adult MHS animals the TGF mechanism was normalized. It could he speculated that the cause of the increased TGF mechanism was dependent on an increased Na-K-2 CI cotransport into the macula densa cells. In SHR rats compared to Wistar-Kyoto at, the TGF sensitivity was also increased but, in contrast. the TGF mechanism was not activated in these animals to retain fluid. Some other mechanism for the development of hypertension in these rats has to be proposed. |
| doi_str_mv | 10.1097/00005344-198800120-00005 |
| format | Article |
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Persson, A Erik ; Boberg, Ulf</creator><creatorcontrib>G. Persson, A Erik ; Boberg, Ulf</creatorcontrib><description>Renal regulation of extracellular fluid volumes via the tubuloglomerular feedback control (TGIF) has been studied in rat experiments. Important modulation of the mechanism was achieved from arterial blood pressure level and extracellular fluid volume via renal interstitial pressure changes. This volume-regulating mechanism has been studied in spontaneously hypertensive rats of the Milan strain (MHS) and compared with Milan normotensive rats (MNS). During development of hypertension, the TMG mechanism was highly sensitive and activated to reduce glomerular filtration rate and retain electrolytes and water. When blood pressure was increased in the adult MHS animals the TGF mechanism was normalized. It could he speculated that the cause of the increased TGF mechanism was dependent on an increased Na-K-2 CI cotransport into the macula densa cells. In SHR rats compared to Wistar-Kyoto at, the TGF sensitivity was also increased but, in contrast. the TGF mechanism was not activated in these animals to retain fluid. Some other mechanism for the development of hypertension in these rats has to be proposed.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198800120-00005</identifier><identifier>PMID: 2467103</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Animals ; Disease Models, Animal ; Hypertension - physiopathology ; Hypertension, Renal - physiopathology ; Kidney - physiopathology ; Rats ; Rats, Inbred SHR</subject><ispartof>Journal of cardiovascular pharmacology, 1988, Vol.12 (3), p.S27-35</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198800120-00005$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4010,4595,27900,27901,27902,65206</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2467103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>G. Persson, A Erik</creatorcontrib><creatorcontrib>Boberg, Ulf</creatorcontrib><title>Renal Abnormalities in Experimental Models of Hypertension: The SHR Versus the Milan HR</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Renal regulation of extracellular fluid volumes via the tubuloglomerular feedback control (TGIF) has been studied in rat experiments. Important modulation of the mechanism was achieved from arterial blood pressure level and extracellular fluid volume via renal interstitial pressure changes. This volume-regulating mechanism has been studied in spontaneously hypertensive rats of the Milan strain (MHS) and compared with Milan normotensive rats (MNS). During development of hypertension, the TMG mechanism was highly sensitive and activated to reduce glomerular filtration rate and retain electrolytes and water. When blood pressure was increased in the adult MHS animals the TGF mechanism was normalized. It could he speculated that the cause of the increased TGF mechanism was dependent on an increased Na-K-2 CI cotransport into the macula densa cells. In SHR rats compared to Wistar-Kyoto at, the TGF sensitivity was also increased but, in contrast. the TGF mechanism was not activated in these animals to retain fluid. Some other mechanism for the development of hypertension in these rats has to be proposed.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension, Renal - physiopathology</subject><subject>Kidney - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVFPwyAUhYnR6Jz-BBOefKtygULnmzFqTVxM5tRHwtpLVmXtLG3m_r3o5t7k5YZzDnDvByEU2AWwkb5kcaVCygRGWcYYcJb8SntkAKkQiWRc7JMBA8USLqU6IschvMegTLU6JIdcKg1MDMjbBGvr6fWsbtqF9VVXYaBVTW-_lthWC6y76I6bEn2gjaP5Osod1qFq6is6nSN9zif0FdvQB9rF7bjytqb55IQcOOsDnm7rkLzc3U5v8uTx6f7h5voxKURsN-GpkxkXrrQu0xxmqCwWJaQOmGZOQCaLkqcwcjYDN7OFtorHoC2hVLbkVgzJ-ebeZdt89hg6s6hCgT52gU0fjM40aFAqBrNNsGibEFp0Zhnns-3aADM_TM0fU7NjupWG5Gz7Rj9bYLk7uIUYfbnxV43vIooP36-wNXO0vpub_75KfAMP54DH</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>G. Persson, A Erik</creator><creator>Boberg, Ulf</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Renal Abnormalities in Experimental Models of Hypertension: The SHR Versus the Milan HR</title><author>G. Persson, A Erik ; Boberg, Ulf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3005-25f4823fdaf8721be6aecd15f1070f3184cd2519fa81fbac7a62872ad1d6ad2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension, Renal - physiopathology</topic><topic>Kidney - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>G. Persson, A Erik</creatorcontrib><creatorcontrib>Boberg, Ulf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>G. Persson, A Erik</au><au>Boberg, Ulf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Abnormalities in Experimental Models of Hypertension: The SHR Versus the Milan HR</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1988</date><risdate>1988</risdate><volume>12</volume><issue>3</issue><spage>S27</spage><epage>35</epage><pages>S27-35</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>Renal regulation of extracellular fluid volumes via the tubuloglomerular feedback control (TGIF) has been studied in rat experiments. Important modulation of the mechanism was achieved from arterial blood pressure level and extracellular fluid volume via renal interstitial pressure changes. This volume-regulating mechanism has been studied in spontaneously hypertensive rats of the Milan strain (MHS) and compared with Milan normotensive rats (MNS). During development of hypertension, the TMG mechanism was highly sensitive and activated to reduce glomerular filtration rate and retain electrolytes and water. When blood pressure was increased in the adult MHS animals the TGF mechanism was normalized. It could he speculated that the cause of the increased TGF mechanism was dependent on an increased Na-K-2 CI cotransport into the macula densa cells. In SHR rats compared to Wistar-Kyoto at, the TGF sensitivity was also increased but, in contrast. the TGF mechanism was not activated in these animals to retain fluid. Some other mechanism for the development of hypertension in these rats has to be proposed.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2467103</pmid><doi>10.1097/00005344-198800120-00005</doi></addata></record> |
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| ispartof | Journal of cardiovascular pharmacology, 1988, Vol.12 (3), p.S27-35 |
| issn | 0160-2446 1533-4023 |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Disease Models, Animal Hypertension - physiopathology Hypertension, Renal - physiopathology Kidney - physiopathology Rats Rats, Inbred SHR |
| title | Renal Abnormalities in Experimental Models of Hypertension: The SHR Versus the Milan HR |
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