Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line

The effect of fluvastatin, an HMG-CoA reductase inhibitor, was investigated on the adhesive interaction between U937 cells, the human monocyte cell line, and human umbilical vein endothelial cells (HUVEC), focusing on the expression of adhesion molecules. U937 treated with fluvastatin lowered the ca...

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Veröffentlicht in:	International journal of immunopharmacology 1996-11, Vol.18 (11), p.669-675
Hauptverfasser:	Niwa, Satoru, Totsuka, Tetsuya, Hayashi, Shigehiro
Format:	Artikel
Sprache:	eng
Schlagworte:	atherosclerosis Biological and medical sciences Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - drug effects Cell Adhesion Molecules - metabolism Cell Adhesion Molecules - physiology Cell Line cellular interaction Depression, Chemical Enzyme-Linked Immunosorbent Assay Fatty Acids, Monounsaturated - pharmacology Flow Cytometry Fluvastatin General and cellular metabolism. Vitamins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology In Vitro Techniques Indoles - pharmacology intercellular adhesion molecule-1 Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - drug effects Intercellular Adhesion Molecule-1 - metabolism Intercellular Adhesion Molecule-1 - physiology lymphocyte function associated antigen-1 Lymphocyte Function-Associated Antigen-1 - biosynthesis Lymphocyte Function-Associated Antigen-1 - drug effects Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocyte Function-Associated Antigen-1 - physiology Medical sciences Mevalonic Acid - pharmacology Monocytes Pharmacology. Drug treatments Pravastatin - pharmacology U937 Umbilical Veins
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