Effects of partial hepatectomy on microtubules and hepatocellular transport of indocyanine green in rats
The effects of partial hepatectomy on plasma disappearance and biliary excretion of indocyanine green (ICG) have been studied in rats and correlated with morphometric changes of hepatocellular microtubules. The plasma disappearance rate of ICG was in good accord with recovery of liver weight after p...
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| Veröffentlicht in: | Virchows Archiv. Abteilung B. Zellpathologie 1988-01, Vol.56 (1), p.5-12 |
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| container_title | Virchows Archiv. Abteilung B. Zellpathologie |
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| creator | FUKUYAMA, T KOGA, A MOMII, S |
| description | The effects of partial hepatectomy on plasma disappearance and biliary excretion of indocyanine green (ICG) have been studied in rats and correlated with morphometric changes of hepatocellular microtubules. The plasma disappearance rate of ICG was in good accord with recovery of liver weight after partial hepatectomy. Biliary excretion of ICG per 100 g liver significantly increased between 3 h and 7 days postoperatively. Colchicine significantly reduced plasma disappearance and biliary excretion of ICG, with no reduction in bile flow, in both intact and hepatectomized rats. Morphometrically, microtubules significantly increased from 3 h following partial hepatectomy and reached a maximum at 24 h with a gradual return to preoperative values at 5 days. These observations suggest that the increased hepatocellular transport of ICG after partial hepatectomy is related to an increase in the number of microtubules. |
| doi_str_mv | 10.1007/BF02889995 |
| format | Article |
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The plasma disappearance rate of ICG was in good accord with recovery of liver weight after partial hepatectomy. Biliary excretion of ICG per 100 g liver significantly increased between 3 h and 7 days postoperatively. Colchicine significantly reduced plasma disappearance and biliary excretion of ICG, with no reduction in bile flow, in both intact and hepatectomized rats. Morphometrically, microtubules significantly increased from 3 h following partial hepatectomy and reached a maximum at 24 h with a gradual return to preoperative values at 5 days. These observations suggest that the increased hepatocellular transport of ICG after partial hepatectomy is related to an increase in the number of microtubules.</description><identifier>ISSN: 0340-6075</identifier><identifier>ISSN: 0042-6431</identifier><identifier>DOI: 10.1007/BF02889995</identifier><identifier>PMID: 2907201</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Colchicine - pharmacology ; Cytoskeleton - ultrastructure ; Hepatectomy ; Indocyanine Green - pharmacokinetics ; Liver - drug effects ; Liver - metabolism ; Liver Regeneration ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Microtubules - ultrastructure ; Rats ; Rats, Inbred Strains ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system</subject><ispartof>Virchows Archiv. Abteilung B. 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Abteilung B. Zellpathologie</title><addtitle>Virchows Arch B Cell Pathol Incl Mol Pathol</addtitle><description>The effects of partial hepatectomy on plasma disappearance and biliary excretion of indocyanine green (ICG) have been studied in rats and correlated with morphometric changes of hepatocellular microtubules. The plasma disappearance rate of ICG was in good accord with recovery of liver weight after partial hepatectomy. Biliary excretion of ICG per 100 g liver significantly increased between 3 h and 7 days postoperatively. Colchicine significantly reduced plasma disappearance and biliary excretion of ICG, with no reduction in bile flow, in both intact and hepatectomized rats. Morphometrically, microtubules significantly increased from 3 h following partial hepatectomy and reached a maximum at 24 h with a gradual return to preoperative values at 5 days. These observations suggest that the increased hepatocellular transport of ICG after partial hepatectomy is related to an increase in the number of microtubules.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colchicine - pharmacology</subject><subject>Cytoskeleton - ultrastructure</subject><subject>Hepatectomy</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver Regeneration</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microtubules - ultrastructure</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0340-6075</issn><issn>0042-6431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhj2ASiks7EgeEANS4Zw4djxC1QJSJRaYI8cfNCixg-0M_fekalSmk-599OruQeiGwCMB4E8vG8jKUghRnKE55BSWDHhxgS5j_AEoClLSGZplAngGZI52a2uNShF7i3sZUiNbvDO9TOPSd3vsHe4aFXwa6qE1EUunj7lXpm2HVgacgnSx9yEdOhqnvdpL1ziDv4MxbtzgIFO8QudWttFcT3OBvjbrz9Xbcvvx-r563i5VTkhaiozUTEhGRM64rVmhaA1WGSG4pVpnhmkgRpOSWZFpRTkQQUELyqipiaX5At0fe_vgfwcTU9U18XCrdMYPseIlJ5ALGMGHIzh-F2MwtupD08mwrwhUB5XVv8oRvp1ah7oz-oROHsf8bsplVLK1oxLVxBPGCckoL_M_GYN-VA</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>FUKUYAMA, T</creator><creator>KOGA, A</creator><creator>MOMII, S</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Effects of partial hepatectomy on microtubules and hepatocellular transport of indocyanine green in rats</title><author>FUKUYAMA, T ; KOGA, A ; MOMII, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-921b69a619367fb65c4b0fce997f4dd2e6d01ed186f92dc4701940d9464eb1f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colchicine - pharmacology</topic><topic>Cytoskeleton - ultrastructure</topic><topic>Hepatectomy</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver Regeneration</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microtubules - ultrastructure</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>online_resources</toplevel><creatorcontrib>FUKUYAMA, T</creatorcontrib><creatorcontrib>KOGA, A</creatorcontrib><creatorcontrib>MOMII, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv. Abteilung B. 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The plasma disappearance rate of ICG was in good accord with recovery of liver weight after partial hepatectomy. Biliary excretion of ICG per 100 g liver significantly increased between 3 h and 7 days postoperatively. Colchicine significantly reduced plasma disappearance and biliary excretion of ICG, with no reduction in bile flow, in both intact and hepatectomized rats. Morphometrically, microtubules significantly increased from 3 h following partial hepatectomy and reached a maximum at 24 h with a gradual return to preoperative values at 5 days. These observations suggest that the increased hepatocellular transport of ICG after partial hepatectomy is related to an increase in the number of microtubules.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2907201</pmid><doi>10.1007/BF02889995</doi><tpages>8</tpages></addata></record> |
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| ispartof | Virchows Archiv. Abteilung B. Zellpathologie, 1988-01, Vol.56 (1), p.5-12 |
| issn | 0340-6075 0042-6431 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Colchicine - pharmacology Cytoskeleton - ultrastructure Hepatectomy Indocyanine Green - pharmacokinetics Liver - drug effects Liver - metabolism Liver Regeneration Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Microtubules - ultrastructure Rats Rats, Inbred Strains Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | Effects of partial hepatectomy on microtubules and hepatocellular transport of indocyanine green in rats |
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