Micellar Nanocarriers Assembled from Doxorubicin-Conjugated Amphiphilic Macromolecules (DOX-AM)

Amphiphilic macromolecules (AMs) have unique branched hydrophobic domains attached to linear PEG chains. AMs self‐assemble in aqueous solution to form micelles that are hydrolytically stable in physiological conditions (37 °C, pH 7.4) over 4 weeks. Evidence of AM biodegradability was demonstrated by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Macromolecular bioscience 2010-04, Vol.10 (4), p.415-423
Hauptverfasser:	del Rosario, Leilani S., Demirdirek, Bahar, Harmon, Alexander, Orban, David, Uhrich, Kathryn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	amphiphilic macromolecules Applied sciences Biodegradability Biological and medical sciences Biological Availability Cell Survival - drug effects Conjugates Dialysis doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - metabolism drug delivery systems Encapsulation Exact sciences and technology General pharmacology Hep G2 Cells Humans Hydrazines - chemistry Hydrogen-Ion Concentration Lauric Acids - chemistry Light Lipase - metabolism Medical sciences Micelles Nanocomposites Nanomaterials Nanostructure Organic polymers Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polyethylene Glycols - chemistry polymer-drug conjugates Properties and characterization Scattering, Radiation Solution and gel properties Spectrophotometry Sugar Acids - chemistry Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry Surface-Active Agents - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!