Comparative pharmacokinetics of some injectable preparations containing ivermectin in dogs

Little is known about the kinetics of ivermectin formulations following subcutaneous administration in dogs. The vehicle components used in production may change the pharmacokinetics of the drug. The present study was aimed at the comparison of the pharmacokinetics of seven injectable ivermectin for...

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Veröffentlicht in:Food and chemical toxicology 2010-08, Vol.48 (8), p.2181-2185
Hauptverfasser: Eraslan, Gökhan, Kanbur, Murat, Liman, Bilal Cem, Çam, Yücel, Karabacak, Mürsel, Altınordulu, Şule
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container_end_page 2185
container_issue 8
container_start_page 2181
container_title Food and chemical toxicology
container_volume 48
creator Eraslan, Gökhan
Kanbur, Murat
Liman, Bilal Cem
Çam, Yücel
Karabacak, Mürsel
Altınordulu, Şule
description Little is known about the kinetics of ivermectin formulations following subcutaneous administration in dogs. The vehicle components used in production may change the pharmacokinetics of the drug. The present study was aimed at the comparison of the pharmacokinetics of seven injectable ivermectin formulation of different brand names (A–G). The animals were allocated to seven groups, each comprising seven dogs. The dogs were administered ivermectin at a dose of 200 μg/kg bw by subcutaneous route and blood samples were collected from all groups up to 288 h post-injection. Plasma ivermectin analyses were performed using a HPLC with a fluorescence detector. Compared to Group 1(A), it was determined that statistically significant differences existed in Groups 2(B), 3(C), 4(D), 5(E), and 7(G) for C max values; and in Groups 3(C), 4(D), 6(F), 7(G) for AUC 0→288 and AUC 0→∞ values. These values were highest in Group 1(A) and lowest in Group 7(F). The results obtained in the present study demonstrated that, in cases which require subacute administration, optimal exposure is achieved with the preparation A. However, it must be noted that this evaluation was based on pharmacokinetic parameters and not antiparasitic efficacy.
doi_str_mv 10.1016/j.fct.2010.05.043
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subjects Animals
Antiparasitic Agents - administration & dosage
Antiparasitic Agents - pharmacokinetics
Area Under Curve
Biological and medical sciences
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Comparative pharmacokinetics
Dog
Dogs
Dose-Response Relationship, Drug
Half-Life
Injectable preparation
Injections
Injections, Subcutaneous
Ivermectin
Ivermectin - administration & dosage
Ivermectin - pharmacokinetics
Male
Medical sciences
Pharmaceutical Solutions
Reproducibility of Results
Toxicology
title Comparative pharmacokinetics of some injectable preparations containing ivermectin in dogs
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