Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice

► AS1535907 represents a novel small-molecule GPR119 agonist that enhances insulin secretion at 16.8 mM glucose in rat islets. ► AS1535907 enhances the first phase of insulin secretion at 16.8 mM glucose in isolated perfused rat pancreas. ► AS1535907 reduces blood glucose levels due to the rapid sec...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-11, Vol.402 (2), p.280-285
Hauptverfasser:	Yoshida, Shigeru, Ohishi, Takahide, Matsui, Tetsuo, Tanaka, Hirotsugu, Oshima, Hiroyuki, Yonetoku, Yasuhiro, Shibasaki, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AS1535907 Cell Line Cyclic N-Oxides - chemistry Cyclic N-Oxides - pharmacology Cyclic N-Oxides - therapeutic use Diabetes Mellitus, Type 2 - drug therapy First-phase insulin secretion Glibenclamide Glucose - metabolism Glucose - pharmacology Glucose Tolerance Test GPR119 Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use In Vitro Techniques Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Isolated perfused pancreas Male Mice Pancreas - drug effects Pancreas - metabolism Perfusion Pyridines - chemistry Pyridines - pharmacology Pyridines - therapeutic use Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - agonists
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