Haematoporphyrin derivative—Photodynamic therapy of colorectal carcinoma, sensitized using verapamil and adriamycin

The p-glycoprotein export mechanism may have an effect on the cytotoxicity of chemotherapy or photodynamic therapy (PDT) by reducing cytotoxic drug or photosensitizer concentration within cells. In tissues over-expressing this protein, modulation with verapamil (an antagonist of p-glycoprotein) may...

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Veröffentlicht in:	Surgical oncology 1996-08, Vol.5 (4), p.169-175
Hauptverfasser:	Purkiss, S.F., Grahn, M.F., Williams, N.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Colorectal Neoplasms - pathology Doxorubicin - administration & dosage Drug Resistance, Neoplasm - physiology experimental antineoplastic agents Haematoporphyrin photoradiation drug resistance Hematoporphyrin Derivative - administration & dosage Humans multiple colonic neoplasms Photochemotherapy Photosensitizing Agents - administration & dosage Tumor Cells, Cultured - drug effects Verapamil - administration & dosage
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