Regional Wall Motion Changes with Dobutamine as a Pharmacological Stress Test during Cardiac Catheterization in Patients with Significant Coronary Artery Disease

Background: Preliminary study to test the feasibility of pharmacological stress testing during cardiac catheterization, thus combining anatomical and functional information. Patients and methods: 21 consecutive patients with known or suspected coronary artery disease, referred for diagnostic cathete...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Japanese Heart Journal 1996, Vol.37(6), pp.847-853
Hauptverfasser: WAGDI, Philipp, FLURI, Martin, ROUVINEZ, Gilles, MEIER, Bernhard
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 853
container_issue 6
container_start_page 847
container_title Japanese Heart Journal
container_volume 37
creator WAGDI, Philipp
FLURI, Martin
ROUVINEZ, Gilles
MEIER, Bernhard
description Background: Preliminary study to test the feasibility of pharmacological stress testing during cardiac catheterization, thus combining anatomical and functional information. Patients and methods: 21 consecutive patients with known or suspected coronary artery disease, referred for diagnostic catheterization. Biplane ventriculography was performed before and during dobutamine infusion. The patients were subdivided into 3 groups: Group I (n=11, 52%) with at least one territory supplied by a significantly stenosed coronary artery and showing normal resting regional wall motion. Group II (n=6, 29%) patients in whom the affected vessel(s) supplied exclusively a territory with regional wall motion ab-normalities at rest. Group III (n=4, 19%) had no significant coronary artery disease and served as control. Results: In group I, 9/11 (82%) patients and in group II, 3/6 (50%) patients showed either ischemia or viability reactions or both after dobutamine stress. Overall, substantial functional information was gathered in 12/17 patients (71%). Control patients showed no worsening of regional wall motion under dobutamine. Neither global left ventricular ejection fraction nor left ventricular end diastolic pressure were as accurate in detecting ischemia as regional wall motion analysis. In patients who had only ischemia and no viability reaction as judged by regional wall motion analysis, ejection fraction fell significantly in 4/6 (67%) patients; end diastolic pressure on the other hand rose significantly in 3/6 (50%). Conclusions: Dobutamine stress testing performed during cardiac catheterization is convenient, feasible and safe and yields clinically useful infor-mation in a high percentage (71%) of patients with significant coronary artery disease. Further experience is needed to evaluate the sensitivity, specificity and predictive value of this new approach.
doi_str_mv 10.1536/ihj.37.847
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78701511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78701511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-f81a4924fb41d81f28c2606fefc6d8b63e7250a2bd64c8a4c678cbfa46187e583</originalsourceid><addsrcrecordid>eNo9kU9v1DAQxSMEKtvChTuSD4hDpSx2nNjeY5XyTyqiokVwiybOOPEqcYrtCJVvwzfFy0Z78dh6P78Z-2XZK0a3rOLinR32Wy63qpRPsg3jpcqF5D-fZhtKC5aXSqjn2XkIe0qZKBQ_y852tJJC7jbZ32_Y29nBSH7AOJIvc0wnUg_gegzkt40DuZ7bJcJkHRIIBMjtAH4CPY9zb3W6eBc9hkDuMUTSLd66ntTgOws61ThgRG__wH9f68ht2qGLq_ed7Z01ycZFUs8-DeIfyZVPVx7JtQ0IAV9kzwyMAV-u9SL7_uH9ff0pv_n68XN9dZPrkhcxN4pBuStK05asU8wUSheCCoNGi061gqMsKgpF24lSKyi1kEq3BkrBlMRK8Yvs7dH3wc-_lvSYZrJB4ziCw3kJjVSSsoqxBF4eQe3nEDya5sHbKQ3eMNoc8mhSHg2XTcojwa9X16WdsDuhawBJf7PqENJnGg9O23DCimpHlaIJq4_YPkTo8aSDj1aPeOjIdoIeuorjkpqfVJ0Sa9Dxf3T5ri8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78701511</pqid></control><display><type>article</type><title>Regional Wall Motion Changes with Dobutamine as a Pharmacological Stress Test during Cardiac Catheterization in Patients with Significant Coronary Artery Disease</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>WAGDI, Philipp ; FLURI, Martin ; ROUVINEZ, Gilles ; MEIER, Bernhard</creator><creatorcontrib>WAGDI, Philipp ; FLURI, Martin ; ROUVINEZ, Gilles ; MEIER, Bernhard</creatorcontrib><description>Background: Preliminary study to test the feasibility of pharmacological stress testing during cardiac catheterization, thus combining anatomical and functional information. Patients and methods: 21 consecutive patients with known or suspected coronary artery disease, referred for diagnostic catheterization. Biplane ventriculography was performed before and during dobutamine infusion. The patients were subdivided into 3 groups: Group I (n=11, 52%) with at least one territory supplied by a significantly stenosed coronary artery and showing normal resting regional wall motion. Group II (n=6, 29%) patients in whom the affected vessel(s) supplied exclusively a territory with regional wall motion ab-normalities at rest. Group III (n=4, 19%) had no significant coronary artery disease and served as control. Results: In group I, 9/11 (82%) patients and in group II, 3/6 (50%) patients showed either ischemia or viability reactions or both after dobutamine stress. Overall, substantial functional information was gathered in 12/17 patients (71%). Control patients showed no worsening of regional wall motion under dobutamine. Neither global left ventricular ejection fraction nor left ventricular end diastolic pressure were as accurate in detecting ischemia as regional wall motion analysis. In patients who had only ischemia and no viability reaction as judged by regional wall motion analysis, ejection fraction fell significantly in 4/6 (67%) patients; end diastolic pressure on the other hand rose significantly in 3/6 (50%). Conclusions: Dobutamine stress testing performed during cardiac catheterization is convenient, feasible and safe and yields clinically useful infor-mation in a high percentage (71%) of patients with significant coronary artery disease. Further experience is needed to evaluate the sensitivity, specificity and predictive value of this new approach.</description><identifier>ISSN: 0021-4868</identifier><identifier>EISSN: 1348-673X</identifier><identifier>DOI: 10.1536/ihj.37.847</identifier><identifier>PMID: 9057679</identifier><identifier>CODEN: JHEJAR</identifier><language>eng</language><publisher>Tokyo: International Heart Journal Association</publisher><subject>Biological and medical sciences ; Cardiac Catheterization ; Cardiology. Vascular system ; Coronary artery disease ; Coronary Disease - diagnosis ; Coronary Disease - physiopathology ; Coronary heart disease ; Dobutamine ; Dobutamine - pharmacology ; Exercise Test ; Feasibility Studies ; Heart ; Humans ; Ischemia ; Medical sciences ; Myocardial Contraction - drug effects ; Predictive Value of Tests ; Sensitivity and Specificity ; Stroke Volume - drug effects ; Ventricular Function, Left - drug effects ; Viability</subject><ispartof>Japanese Heart Journal, 1996, Vol.37(6), pp.847-853</ispartof><rights>by International Heart Journal Association</rights><rights>1997 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2590880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9057679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WAGDI, Philipp</creatorcontrib><creatorcontrib>FLURI, Martin</creatorcontrib><creatorcontrib>ROUVINEZ, Gilles</creatorcontrib><creatorcontrib>MEIER, Bernhard</creatorcontrib><title>Regional Wall Motion Changes with Dobutamine as a Pharmacological Stress Test during Cardiac Catheterization in Patients with Significant Coronary Artery Disease</title><title>Japanese Heart Journal</title><addtitle>Jpn Heart J</addtitle><description>Background: Preliminary study to test the feasibility of pharmacological stress testing during cardiac catheterization, thus combining anatomical and functional information. Patients and methods: 21 consecutive patients with known or suspected coronary artery disease, referred for diagnostic catheterization. Biplane ventriculography was performed before and during dobutamine infusion. The patients were subdivided into 3 groups: Group I (n=11, 52%) with at least one territory supplied by a significantly stenosed coronary artery and showing normal resting regional wall motion. Group II (n=6, 29%) patients in whom the affected vessel(s) supplied exclusively a territory with regional wall motion ab-normalities at rest. Group III (n=4, 19%) had no significant coronary artery disease and served as control. Results: In group I, 9/11 (82%) patients and in group II, 3/6 (50%) patients showed either ischemia or viability reactions or both after dobutamine stress. Overall, substantial functional information was gathered in 12/17 patients (71%). Control patients showed no worsening of regional wall motion under dobutamine. Neither global left ventricular ejection fraction nor left ventricular end diastolic pressure were as accurate in detecting ischemia as regional wall motion analysis. In patients who had only ischemia and no viability reaction as judged by regional wall motion analysis, ejection fraction fell significantly in 4/6 (67%) patients; end diastolic pressure on the other hand rose significantly in 3/6 (50%). Conclusions: Dobutamine stress testing performed during cardiac catheterization is convenient, feasible and safe and yields clinically useful infor-mation in a high percentage (71%) of patients with significant coronary artery disease. Further experience is needed to evaluate the sensitivity, specificity and predictive value of this new approach.</description><subject>Biological and medical sciences</subject><subject>Cardiac Catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Dobutamine</subject><subject>Dobutamine - pharmacology</subject><subject>Exercise Test</subject><subject>Feasibility Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Predictive Value of Tests</subject><subject>Sensitivity and Specificity</subject><subject>Stroke Volume - drug effects</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Viability</subject><issn>0021-4868</issn><issn>1348-673X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9v1DAQxSMEKtvChTuSD4hDpSx2nNjeY5XyTyqiokVwiybOOPEqcYrtCJVvwzfFy0Z78dh6P78Z-2XZK0a3rOLinR32Wy63qpRPsg3jpcqF5D-fZhtKC5aXSqjn2XkIe0qZKBQ_y852tJJC7jbZ32_Y29nBSH7AOJIvc0wnUg_gegzkt40DuZ7bJcJkHRIIBMjtAH4CPY9zb3W6eBc9hkDuMUTSLd66ntTgOws61ThgRG__wH9f68ht2qGLq_ed7Z01ycZFUs8-DeIfyZVPVx7JtQ0IAV9kzwyMAV-u9SL7_uH9ff0pv_n68XN9dZPrkhcxN4pBuStK05asU8wUSheCCoNGi061gqMsKgpF24lSKyi1kEq3BkrBlMRK8Yvs7dH3wc-_lvSYZrJB4ziCw3kJjVSSsoqxBF4eQe3nEDya5sHbKQ3eMNoc8mhSHg2XTcojwa9X16WdsDuhawBJf7PqENJnGg9O23DCimpHlaIJq4_YPkTo8aSDj1aPeOjIdoIeuorjkpqfVJ0Sa9Dxf3T5ri8</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>WAGDI, Philipp</creator><creator>FLURI, Martin</creator><creator>ROUVINEZ, Gilles</creator><creator>MEIER, Bernhard</creator><general>International Heart Journal Association</general><general>Japanese Heart Journal Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Regional Wall Motion Changes with Dobutamine as a Pharmacological Stress Test during Cardiac Catheterization in Patients with Significant Coronary Artery Disease</title><author>WAGDI, Philipp ; FLURI, Martin ; ROUVINEZ, Gilles ; MEIER, Bernhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-f81a4924fb41d81f28c2606fefc6d8b63e7250a2bd64c8a4c678cbfa46187e583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Cardiac Catheterization</topic><topic>Cardiology. Vascular system</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Dobutamine</topic><topic>Dobutamine - pharmacology</topic><topic>Exercise Test</topic><topic>Feasibility Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><topic>Stroke Volume - drug effects</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Viability</topic><toplevel>online_resources</toplevel><creatorcontrib>WAGDI, Philipp</creatorcontrib><creatorcontrib>FLURI, Martin</creatorcontrib><creatorcontrib>ROUVINEZ, Gilles</creatorcontrib><creatorcontrib>MEIER, Bernhard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WAGDI, Philipp</au><au>FLURI, Martin</au><au>ROUVINEZ, Gilles</au><au>MEIER, Bernhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional Wall Motion Changes with Dobutamine as a Pharmacological Stress Test during Cardiac Catheterization in Patients with Significant Coronary Artery Disease</atitle><jtitle>Japanese Heart Journal</jtitle><addtitle>Jpn Heart J</addtitle><date>1996</date><risdate>1996</risdate><volume>37</volume><issue>6</issue><spage>847</spage><epage>853</epage><pages>847-853</pages><issn>0021-4868</issn><eissn>1348-673X</eissn><coden>JHEJAR</coden><abstract>Background: Preliminary study to test the feasibility of pharmacological stress testing during cardiac catheterization, thus combining anatomical and functional information. Patients and methods: 21 consecutive patients with known or suspected coronary artery disease, referred for diagnostic catheterization. Biplane ventriculography was performed before and during dobutamine infusion. The patients were subdivided into 3 groups: Group I (n=11, 52%) with at least one territory supplied by a significantly stenosed coronary artery and showing normal resting regional wall motion. Group II (n=6, 29%) patients in whom the affected vessel(s) supplied exclusively a territory with regional wall motion ab-normalities at rest. Group III (n=4, 19%) had no significant coronary artery disease and served as control. Results: In group I, 9/11 (82%) patients and in group II, 3/6 (50%) patients showed either ischemia or viability reactions or both after dobutamine stress. Overall, substantial functional information was gathered in 12/17 patients (71%). Control patients showed no worsening of regional wall motion under dobutamine. Neither global left ventricular ejection fraction nor left ventricular end diastolic pressure were as accurate in detecting ischemia as regional wall motion analysis. In patients who had only ischemia and no viability reaction as judged by regional wall motion analysis, ejection fraction fell significantly in 4/6 (67%) patients; end diastolic pressure on the other hand rose significantly in 3/6 (50%). Conclusions: Dobutamine stress testing performed during cardiac catheterization is convenient, feasible and safe and yields clinically useful infor-mation in a high percentage (71%) of patients with significant coronary artery disease. Further experience is needed to evaluate the sensitivity, specificity and predictive value of this new approach.</abstract><cop>Tokyo</cop><pub>International Heart Journal Association</pub><pmid>9057679</pmid><doi>10.1536/ihj.37.847</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0021-4868
ispartof Japanese Heart Journal, 1996, Vol.37(6), pp.847-853
issn 0021-4868
1348-673X
language eng
recordid cdi_proquest_miscellaneous_78701511
source J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Biological and medical sciences
Cardiac Catheterization
Cardiology. Vascular system
Coronary artery disease
Coronary Disease - diagnosis
Coronary Disease - physiopathology
Coronary heart disease
Dobutamine
Dobutamine - pharmacology
Exercise Test
Feasibility Studies
Heart
Humans
Ischemia
Medical sciences
Myocardial Contraction - drug effects
Predictive Value of Tests
Sensitivity and Specificity
Stroke Volume - drug effects
Ventricular Function, Left - drug effects
Viability
title Regional Wall Motion Changes with Dobutamine as a Pharmacological Stress Test during Cardiac Catheterization in Patients with Significant Coronary Artery Disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A37%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regional%20Wall%20Motion%20Changes%20with%20Dobutamine%20as%20a%20Pharmacological%20Stress%20Test%20during%20Cardiac%20Catheterization%20in%20Patients%20with%20Significant%20Coronary%20Artery%20Disease&rft.jtitle=Japanese%20Heart%20Journal&rft.au=WAGDI,%20Philipp&rft.date=1996&rft.volume=37&rft.issue=6&rft.spage=847&rft.epage=853&rft.pages=847-853&rft.issn=0021-4868&rft.eissn=1348-673X&rft.coden=JHEJAR&rft_id=info:doi/10.1536/ihj.37.847&rft_dat=%3Cproquest_cross%3E78701511%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78701511&rft_id=info:pmid/9057679&rfr_iscdi=true