Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers
The serum activity of creatine kinase (CK) and pyruvate kinase (PK) was measured in 98 pairs of same‐sex Brazilian twins. The purpose of this study was to estimate the genetic and environmental components of serum activity levels for both enzymes. Heritabilities were estimated separately by path ana...
Gespeichert in:
| Veröffentlicht in: | American journal of medical genetics 1988-10, Vol.31 (2), p.291-298 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 298 |
|---|---|
| container_issue | 2 |
| container_start_page | 291 |
| container_title | American journal of medical genetics |
| container_volume | 31 |
| creator | Rapaport, Debora Colletto, Gloria M. D. D. Zatz, Mayana Opitz, John M. Reynolds, James F. |
| description | The serum activity of creatine kinase (CK) and pyruvate kinase (PK) was measured in 98 pairs of same‐sex Brazilian twins. The purpose of this study was to estimate the genetic and environmental components of serum activity levels for both enzymes. Heritabilities were estimated separately by path analysis in each sex. The results showed that CK and PK activities are under genetic control in normal males and females. Environmental components were not statistically significant for CK or PK. The genetic components of both enzymes estimated in females has implications in the calculation of genetic risks for Duchenne muscular dystrophy carriers. |
| doi_str_mv | 10.1002/ajmg.1320310206 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78695031</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78695031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4116-90323ab73da874bce38bfbc61502c9f0a1613c836ca510292f6c975372ba35333</originalsourceid><addsrcrecordid>eNqFUctu1DAUtRCoDIU1KyQvEIJFWj8mTlJW1bSEQnkIhsfOcjxO605ip75JS_6Nj8PDRFOxYmXL53WvD0JPKTmghLBDddVeHFDOCKeEEXEPzSgpRJILlt9HM0LneZKxoniIHgFcEULjA9tDe5xxJopshn6XxpneaqzcCht3Y4N3rXG9arD2beddvAP2NQYThhbrYFRvncFr6xQY_HLx_tVfaTeG4Ub1d8DnCFiHnQ9t9OpvrYMjfNZ2jdXRwTtc-4AvpvBgYQ3YQG_b6AEb4cmgL42LSe0AemhUwKsR-uC7yxFrFYI1AR6jB7VqwDyZzn307c3pcvE2Of9Uni2OzxM9p1QkBYnrqirjK5Vn80obnld1pQVNCdNFTRQVlOucC63S-IsFq4UuspRnrFI85Zzvoxdb3y746yGOKVsL2jSNcsYPILNcFGlsIBIPt0QdPEAwtexCXCmMkhK56Utu-pJ3fUXFs8l6qFqz2vGngiL-fMIVaNXUQTltYUcTheAZ3Uz4eku7tY0Z_5cqj999KP8ZItmqLfTm106twlqKjGep_PGxlPn3LyfL5c9SfuV_APFawcU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78695031</pqid></control><display><type>article</type><title>Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Rapaport, Debora ; Colletto, Gloria M. D. D. ; Zatz, Mayana ; Opitz, John M. ; Reynolds, James F.</creator><creatorcontrib>Rapaport, Debora ; Colletto, Gloria M. D. D. ; Zatz, Mayana ; Opitz, John M. ; Reynolds, James F.</creatorcontrib><description>The serum activity of creatine kinase (CK) and pyruvate kinase (PK) was measured in 98 pairs of same‐sex Brazilian twins. The purpose of this study was to estimate the genetic and environmental components of serum activity levels for both enzymes. Heritabilities were estimated separately by path analysis in each sex. The results showed that CK and PK activities are under genetic control in normal males and females. Environmental components were not statistically significant for CK or PK. The genetic components of both enzymes estimated in females has implications in the calculation of genetic risks for Duchenne muscular dystrophy carriers.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/ajmg.1320310206</identifier><identifier>PMID: 3232697</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; creatine kinase ; Creatine Kinase - blood ; Creatine Kinase - genetics ; Dermatoglyphics ; Diseases of striated muscles. Neuromuscular diseases ; Duchenne muscular dystrophy ; Environment ; Female ; heritability ; Humans ; Male ; Medical sciences ; Models, Genetic ; Models, Statistical ; Muscular Dystrophies - genetics ; Neurology ; pyruvate kinase ; Pyruvate Kinase - blood ; Pyruvate Kinase - genetics ; Reference Values ; Risk Factors ; Twins ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>American journal of medical genetics, 1988-10, Vol.31 (2), p.291-298</ispartof><rights>Copyright © 1988 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1990 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4116-90323ab73da874bce38bfbc61502c9f0a1613c836ca510292f6c975372ba35333</citedby><cites>FETCH-LOGICAL-c4116-90323ab73da874bce38bfbc61502c9f0a1613c836ca510292f6c975372ba35333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6963713$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3232697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rapaport, Debora</creatorcontrib><creatorcontrib>Colletto, Gloria M. D. D.</creatorcontrib><creatorcontrib>Zatz, Mayana</creatorcontrib><creatorcontrib>Opitz, John M.</creatorcontrib><creatorcontrib>Reynolds, James F.</creatorcontrib><title>Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>The serum activity of creatine kinase (CK) and pyruvate kinase (PK) was measured in 98 pairs of same‐sex Brazilian twins. The purpose of this study was to estimate the genetic and environmental components of serum activity levels for both enzymes. Heritabilities were estimated separately by path analysis in each sex. The results showed that CK and PK activities are under genetic control in normal males and females. Environmental components were not statistically significant for CK or PK. The genetic components of both enzymes estimated in females has implications in the calculation of genetic risks for Duchenne muscular dystrophy carriers.</description><subject>Biological and medical sciences</subject><subject>creatine kinase</subject><subject>Creatine Kinase - blood</subject><subject>Creatine Kinase - genetics</subject><subject>Dermatoglyphics</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Duchenne muscular dystrophy</subject><subject>Environment</subject><subject>Female</subject><subject>heritability</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Genetic</subject><subject>Models, Statistical</subject><subject>Muscular Dystrophies - genetics</subject><subject>Neurology</subject><subject>pyruvate kinase</subject><subject>Pyruvate Kinase - blood</subject><subject>Pyruvate Kinase - genetics</subject><subject>Reference Values</subject><subject>Risk Factors</subject><subject>Twins</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCoDIU1KyQvEIJFWj8mTlJW1bSEQnkIhsfOcjxO605ip75JS_6Nj8PDRFOxYmXL53WvD0JPKTmghLBDddVeHFDOCKeEEXEPzSgpRJILlt9HM0LneZKxoniIHgFcEULjA9tDe5xxJopshn6XxpneaqzcCht3Y4N3rXG9arD2beddvAP2NQYThhbrYFRvncFr6xQY_HLx_tVfaTeG4Ub1d8DnCFiHnQ9t9OpvrYMjfNZ2jdXRwTtc-4AvpvBgYQ3YQG_b6AEb4cmgL42LSe0AemhUwKsR-uC7yxFrFYI1AR6jB7VqwDyZzn307c3pcvE2Of9Uni2OzxM9p1QkBYnrqirjK5Vn80obnld1pQVNCdNFTRQVlOucC63S-IsFq4UuspRnrFI85Zzvoxdb3y746yGOKVsL2jSNcsYPILNcFGlsIBIPt0QdPEAwtexCXCmMkhK56Utu-pJ3fUXFs8l6qFqz2vGngiL-fMIVaNXUQTltYUcTheAZ3Uz4eku7tY0Z_5cqj999KP8ZItmqLfTm106twlqKjGep_PGxlPn3LyfL5c9SfuV_APFawcU</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>Rapaport, Debora</creator><creator>Colletto, Gloria M. D. D.</creator><creator>Zatz, Mayana</creator><creator>Opitz, John M.</creator><creator>Reynolds, James F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198810</creationdate><title>Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers</title><author>Rapaport, Debora ; Colletto, Gloria M. D. D. ; Zatz, Mayana ; Opitz, John M. ; Reynolds, James F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4116-90323ab73da874bce38bfbc61502c9f0a1613c836ca510292f6c975372ba35333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>creatine kinase</topic><topic>Creatine Kinase - blood</topic><topic>Creatine Kinase - genetics</topic><topic>Dermatoglyphics</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Duchenne muscular dystrophy</topic><topic>Environment</topic><topic>Female</topic><topic>heritability</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Genetic</topic><topic>Models, Statistical</topic><topic>Muscular Dystrophies - genetics</topic><topic>Neurology</topic><topic>pyruvate kinase</topic><topic>Pyruvate Kinase - blood</topic><topic>Pyruvate Kinase - genetics</topic><topic>Reference Values</topic><topic>Risk Factors</topic><topic>Twins</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>online_resources</toplevel><creatorcontrib>Rapaport, Debora</creatorcontrib><creatorcontrib>Colletto, Gloria M. D. D.</creatorcontrib><creatorcontrib>Zatz, Mayana</creatorcontrib><creatorcontrib>Opitz, John M.</creatorcontrib><creatorcontrib>Reynolds, James F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rapaport, Debora</au><au>Colletto, Gloria M. D. D.</au><au>Zatz, Mayana</au><au>Opitz, John M.</au><au>Reynolds, James F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers</atitle><jtitle>American journal of medical genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>1988-10</date><risdate>1988</risdate><volume>31</volume><issue>2</issue><spage>291</spage><epage>298</epage><pages>291-298</pages><issn>0148-7299</issn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>The serum activity of creatine kinase (CK) and pyruvate kinase (PK) was measured in 98 pairs of same‐sex Brazilian twins. The purpose of this study was to estimate the genetic and environmental components of serum activity levels for both enzymes. Heritabilities were estimated separately by path analysis in each sex. The results showed that CK and PK activities are under genetic control in normal males and females. Environmental components were not statistically significant for CK or PK. The genetic components of both enzymes estimated in females has implications in the calculation of genetic risks for Duchenne muscular dystrophy carriers.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3232697</pmid><doi>10.1002/ajmg.1320310206</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-7299 |
| ispartof | American journal of medical genetics, 1988-10, Vol.31 (2), p.291-298 |
| issn | 0148-7299 1096-8628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78695031 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biological and medical sciences creatine kinase Creatine Kinase - blood Creatine Kinase - genetics Dermatoglyphics Diseases of striated muscles. Neuromuscular diseases Duchenne muscular dystrophy Environment Female heritability Humans Male Medical sciences Models, Genetic Models, Statistical Muscular Dystrophies - genetics Neurology pyruvate kinase Pyruvate Kinase - blood Pyruvate Kinase - genetics Reference Values Risk Factors Twins Twins, Dizygotic Twins, Monozygotic |
| title | Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T08%3A14%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20and%20environmental%20components%20of%20serum%20creatine%20kinase%20(CK)%20and%20pyruvate%20kinase%20(PK)%20in%20normal%20twins:%20Implication%20for%20genetic%20risks%20estimates%20in%20Duchenne%20muscular%20dystrophy%20carriers&rft.jtitle=American%20journal%20of%20medical%20genetics&rft.au=Rapaport,%20Debora&rft.date=1988-10&rft.volume=31&rft.issue=2&rft.spage=291&rft.epage=298&rft.pages=291-298&rft.issn=0148-7299&rft.eissn=1096-8628&rft.coden=AJMGDA&rft_id=info:doi/10.1002/ajmg.1320310206&rft_dat=%3Cproquest_cross%3E78695031%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78695031&rft_id=info:pmid/3232697&rfr_iscdi=true |