Effect of bombesin on behaviors associated with ethanol satiation and blood ethanol levels
The behavioral specificity and physiological significance of bombesin-induced inhibition of ethanol intake were assessed in water-deprived rats. The behavioral display accompanying suppression of 5% ethanol intake by bombesin tetradecapeptide (BBS-14, 1–4 μg/kg) was measured with an instantaneous ti...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 1988-07, Vol.5 (4), p.325-330 |
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| creator | Glazner, G.W. Cannon, R.L. Kulkosky, P.J. |
| description | The behavioral specificity and physiological significance of bombesin-induced inhibition of ethanol intake were assessed in water-deprived rats. The behavioral display accompanying suppression of 5% ethanol intake by bombesin tetradecapeptide (BBS-14, 1–4 μg/kg) was measured with an instantaneous time-sampling technique. Blood ethanol levels were measured after peripheral BBS-14 and bombesin nonapeptide (BBS-9) administration, and after either oral self-administration or peripheral injection of ethanol. The display accompanying BBS-14-reduced ethanol consumption differed from control in that less drinking and feeding behaviors were observed and resting increased, dose-dependently. The typical behavioral sequence of ethanol satiation was observed in all conditions. Both BBS-14 and -9 reduced blood ethanol levels when oral intake was suppressed, and BBS-14 did not affect blood ethanol levels or elimination rate when ethanol was injected. The results are compatible with an hypothesis of a functional role for endogenous bombesin-like peptides and receptors in a neuropeptide control of ethanol intake and energy balance. |
| doi_str_mv | 10.1016/0741-8329(88)90074-2 |
| format | Article |
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The behavioral display accompanying suppression of 5% ethanol intake by bombesin tetradecapeptide (BBS-14, 1–4 μg/kg) was measured with an instantaneous time-sampling technique. Blood ethanol levels were measured after peripheral BBS-14 and bombesin nonapeptide (BBS-9) administration, and after either oral self-administration or peripheral injection of ethanol. The display accompanying BBS-14-reduced ethanol consumption differed from control in that less drinking and feeding behaviors were observed and resting increased, dose-dependently. The typical behavioral sequence of ethanol satiation was observed in all conditions. Both BBS-14 and -9 reduced blood ethanol levels when oral intake was suppressed, and BBS-14 did not affect blood ethanol levels or elimination rate when ethanol was injected. 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The behavioral display accompanying suppression of 5% ethanol intake by bombesin tetradecapeptide (BBS-14, 1–4 μg/kg) was measured with an instantaneous time-sampling technique. Blood ethanol levels were measured after peripheral BBS-14 and bombesin nonapeptide (BBS-9) administration, and after either oral self-administration or peripheral injection of ethanol. The display accompanying BBS-14-reduced ethanol consumption differed from control in that less drinking and feeding behaviors were observed and resting increased, dose-dependently. The typical behavioral sequence of ethanol satiation was observed in all conditions. Both BBS-14 and -9 reduced blood ethanol levels when oral intake was suppressed, and BBS-14 did not affect blood ethanol levels or elimination rate when ethanol was injected. The results are compatible with an hypothesis of a functional role for endogenous bombesin-like peptides and receptors in a neuropeptide control of ethanol intake and energy balance.</description><subject>Alcohol Drinking - drug effects</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blood ethanol</subject><subject>Bombesin</subject><subject>Bombesin - pharmacology</subject><subject>Bombesin - physiology</subject><subject>Bombesin nonapeptide</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking - drug effects</subject><subject>Eating - drug effects</subject><subject>Ethanol</subject><subject>Ethanol - blood</subject><subject>Ethanol intake</subject><subject>Ethanol satiation</subject><subject>Grooming - drug effects</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicology</subject><subject>Water Deprivation</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo67j6DxRyENFDr_noSdIXQZb1Axb2sl68hEpSzUR6OmuqZ2T_vRlnmKOnUHmfKpKnGHstxZUU0nwUtped02p479yHQbSyU0_YSjqrO-OUfspWZ-Q5e0H0SzTI2uGCXWilXO_WK_bzZhwxLryMPJRtQMozLzMPuIF9LpU4EJWYYcHE_-Rlw3HZwFwmTrC029xYmBMPUynpnE24x4lesmcjTISvTucl-_Hl5v76W3d79_X79efbLmpnlk6rvhe90gDGghQYBWhlY-yHtTMSUnJggpLCghFhdHKIazMEnYRSsf066Ev27jj3oZbfO6TFbzNFnCaYsezIW2ecM2LdwP4IxlqIKo7-oeYt1EcvhT8o9Qdf_uDLO-f_KfWqtb05zd-FLaZz08lhy9-ecqAI01hhjpnOmFViGHrRsE9HrKnBfcbqKWacI6Zc2wZ8Kvn_7_gLhuWSBQ</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Glazner, G.W.</creator><creator>Cannon, R.L.</creator><creator>Kulkosky, P.J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Effect of bombesin on behaviors associated with ethanol satiation and blood ethanol levels</title><author>Glazner, G.W. ; Cannon, R.L. ; Kulkosky, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-32440423aa67a10ec0a327cc495861add8a6b2107a60bf819c569b3d022c900b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alcohol Drinking - drug effects</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood ethanol</topic><topic>Bombesin</topic><topic>Bombesin - pharmacology</topic><topic>Bombesin - physiology</topic><topic>Bombesin nonapeptide</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking - drug effects</topic><topic>Eating - drug effects</topic><topic>Ethanol</topic><topic>Ethanol - blood</topic><topic>Ethanol intake</topic><topic>Ethanol satiation</topic><topic>Grooming - drug effects</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicology</topic><topic>Water Deprivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glazner, G.W.</creatorcontrib><creatorcontrib>Cannon, R.L.</creatorcontrib><creatorcontrib>Kulkosky, P.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glazner, G.W.</au><au>Cannon, R.L.</au><au>Kulkosky, P.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of bombesin on behaviors associated with ethanol satiation and blood ethanol levels</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>5</volume><issue>4</issue><spage>325</spage><epage>330</epage><pages>325-330</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><coden>ALCOEX</coden><abstract>The behavioral specificity and physiological significance of bombesin-induced inhibition of ethanol intake were assessed in water-deprived rats. The behavioral display accompanying suppression of 5% ethanol intake by bombesin tetradecapeptide (BBS-14, 1–4 μg/kg) was measured with an instantaneous time-sampling technique. Blood ethanol levels were measured after peripheral BBS-14 and bombesin nonapeptide (BBS-9) administration, and after either oral self-administration or peripheral injection of ethanol. The display accompanying BBS-14-reduced ethanol consumption differed from control in that less drinking and feeding behaviors were observed and resting increased, dose-dependently. The typical behavioral sequence of ethanol satiation was observed in all conditions. Both BBS-14 and -9 reduced blood ethanol levels when oral intake was suppressed, and BBS-14 did not affect blood ethanol levels or elimination rate when ethanol was injected. The results are compatible with an hypothesis of a functional role for endogenous bombesin-like peptides and receptors in a neuropeptide control of ethanol intake and energy balance.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3228485</pmid><doi>10.1016/0741-8329(88)90074-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Alcohol (Fayetteville, N.Y.), 1988-07, Vol.5 (4), p.325-330 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Alcohol Drinking - drug effects Alcoholism and acute alcohol poisoning Animals Behavior, Animal - drug effects Biological and medical sciences Blood ethanol Bombesin Bombesin - pharmacology Bombesin - physiology Bombesin nonapeptide Dose-Response Relationship, Drug Drinking - drug effects Eating - drug effects Ethanol Ethanol - blood Ethanol intake Ethanol satiation Grooming - drug effects Medical sciences Motor Activity - drug effects Rat Rats Rats, Inbred Strains Toxicology Water Deprivation |
| title | Effect of bombesin on behaviors associated with ethanol satiation and blood ethanol levels |
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