Experimental erbium laser surgery in the guinea pig cochlea : its use in the study of afferent cochlear neurotransmitters
Microiontophoretic techniques were used to examine the changes in activity of inner half cell afferents in the guinea pig following circumscribed penetration of cochlear bone with erbium:YSGG laser pulses. Neuronal responses to the application of the glutamate agonists N-methyl-D-aspartate (NMDA) an...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 1996, Vol.253 (8), p.460-463 |
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| container_title | European archives of oto-rhino-laryngology |
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| creator | ARNOLD, A EHRENBERGER, K FRENZ, M PRATISTO, H WEBER, H. P ALTERMATT, H. J FELIX, D |
| description | Microiontophoretic techniques were used to examine the changes in activity of inner half cell afferents in the guinea pig following circumscribed penetration of cochlear bone with erbium:YSGG laser pulses. Neuronal responses to the application of the glutamate agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) before laser use and after return to normal spontaneous activity were equivalent, implying total reversibility of the changes occurring. Suppression of laser-induced hair cell activity was possible with NMDA and AMPA receptor antagonists and lasted 10-15 min. These findings suggest a transmitter-related increase of neuronal activity. Our results show that use of the erbium laser in inner ear microsurgery might be possible with low risk if the amount of energy applied is kept under a safe limit of 10 J/cm2. |
| doi_str_mv | 10.1007/BF00179950 |
| format | Article |
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P ; ALTERMATT, H. J ; FELIX, D</creator><creatorcontrib>ARNOLD, A ; EHRENBERGER, K ; FRENZ, M ; PRATISTO, H ; WEBER, H. P ; ALTERMATT, H. J ; FELIX, D</creatorcontrib><description>Microiontophoretic techniques were used to examine the changes in activity of inner half cell afferents in the guinea pig following circumscribed penetration of cochlear bone with erbium:YSGG laser pulses. Neuronal responses to the application of the glutamate agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) before laser use and after return to normal spontaneous activity were equivalent, implying total reversibility of the changes occurring. Suppression of laser-induced hair cell activity was possible with NMDA and AMPA receptor antagonists and lasted 10-15 min. These findings suggest a transmitter-related increase of neuronal activity. Our results show that use of the erbium laser in inner ear microsurgery might be possible with low risk if the amount of energy applied is kept under a safe limit of 10 J/cm2.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/BF00179950</identifier><identifier>PMID: 9044567</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage ; Animals ; Biological and medical sciences ; Cochlea - drug effects ; Cochlea - physiology ; Cochlea - surgery ; Erbium ; Excitatory Amino Acid Agonists - administration & dosage ; Excitatory Amino Acid Antagonists - administration & dosage ; Female ; Guinea Pigs ; Hair Cells, Auditory, Inner - drug effects ; Hair Cells, Auditory, Inner - physiology ; Hair Cells, Auditory, Inner - radiation effects ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Iontophoresis ; Laser Therapy ; Male ; Medical sciences ; Microelectrodes ; N-Methylaspartate - administration & dosage ; Neurotransmitter Agents - physiology ; Neurotransmitter Agents - radiation effects ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the ear, the auditive nerve and the facial nerve ; Synaptic Transmission - drug effects ; Synaptic Transmission - radiation effects</subject><ispartof>European archives of oto-rhino-laryngology, 1996, Vol.253 (8), p.460-463</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-aaf3564ba429555b6cef4792caf5cbdf1ffa3359b14fe0cdcc14597be4d845003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2476325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9044567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARNOLD, A</creatorcontrib><creatorcontrib>EHRENBERGER, K</creatorcontrib><creatorcontrib>FRENZ, M</creatorcontrib><creatorcontrib>PRATISTO, H</creatorcontrib><creatorcontrib>WEBER, H. P</creatorcontrib><creatorcontrib>ALTERMATT, H. J</creatorcontrib><creatorcontrib>FELIX, D</creatorcontrib><title>Experimental erbium laser surgery in the guinea pig cochlea : its use in the study of afferent cochlear neurotransmitters</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Microiontophoretic techniques were used to examine the changes in activity of inner half cell afferents in the guinea pig following circumscribed penetration of cochlear bone with erbium:YSGG laser pulses. Neuronal responses to the application of the glutamate agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) before laser use and after return to normal spontaneous activity were equivalent, implying total reversibility of the changes occurring. Suppression of laser-induced hair cell activity was possible with NMDA and AMPA receptor antagonists and lasted 10-15 min. These findings suggest a transmitter-related increase of neuronal activity. Our results show that use of the erbium laser in inner ear microsurgery might be possible with low risk if the amount of energy applied is kept under a safe limit of 10 J/cm2.</description><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage</subject><subject>alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cochlea - drug effects</subject><subject>Cochlea - physiology</subject><subject>Cochlea - surgery</subject><subject>Erbium</subject><subject>Excitatory Amino Acid Agonists - administration & dosage</subject><subject>Excitatory Amino Acid Antagonists - administration & dosage</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Hair Cells, Auditory, Inner - drug effects</subject><subject>Hair Cells, Auditory, Inner - physiology</subject><subject>Hair Cells, Auditory, Inner - radiation effects</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Iontophoresis</subject><subject>Laser Therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microelectrodes</subject><subject>N-Methylaspartate - administration & dosage</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Neurotransmitter Agents - radiation effects</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the ear, the auditive nerve and the facial nerve</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - radiation effects</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtLBDEUhYMouj4aeyGFWAijySSZbOxU1gcINloPmczNGpnHmpuA--8dcdXqHjgfB-5HyDFnF5wxfXlzxxjXxii2RWZcCllIXVbbZMaM0IWUWu-RfcR3xpiSRuySXcOkVJWekfXicwUx9DAk21GITcg97SxCpJjjEuKahoGmN6DLHAawdBWW1I3urZvyFQ0JaUb4ZTDldk1HT633EKfNXzTSAXIcU7QD9iEliHhIdrztEI4294C83i1ebh-Kp-f7x9vrp8IJzlNhrReqko2VpVFKNZUDL7UpnfXKNa3n3lshlGm49MBc6xyXyugGZDuXijFxQM5-dldx_MiAqe4DOug6O8CYsdbzaq61ERN4_gO6OCJG8PVqEmPjuuas_vZc_3ue4JPNam56aP_QjdipP930Fp3t_PS4C_iHlVJXolTiC0gxhvc</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>ARNOLD, A</creator><creator>EHRENBERGER, K</creator><creator>FRENZ, M</creator><creator>PRATISTO, H</creator><creator>WEBER, H. P</creator><creator>ALTERMATT, H. J</creator><creator>FELIX, D</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Experimental erbium laser surgery in the guinea pig cochlea : its use in the study of afferent cochlear neurotransmitters</title><author>ARNOLD, A ; EHRENBERGER, K ; FRENZ, M ; PRATISTO, H ; WEBER, H. P ; ALTERMATT, H. J ; FELIX, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-aaf3564ba429555b6cef4792caf5cbdf1ffa3359b14fe0cdcc14597be4d845003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage</topic><topic>alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cochlea - drug effects</topic><topic>Cochlea - physiology</topic><topic>Cochlea - surgery</topic><topic>Erbium</topic><topic>Excitatory Amino Acid Agonists - administration & dosage</topic><topic>Excitatory Amino Acid Antagonists - administration & dosage</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Hair Cells, Auditory, Inner - drug effects</topic><topic>Hair Cells, Auditory, Inner - physiology</topic><topic>Hair Cells, Auditory, Inner - radiation effects</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Iontophoresis</topic><topic>Laser Therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microelectrodes</topic><topic>N-Methylaspartate - administration & dosage</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Neurotransmitter Agents - radiation effects</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the ear, the auditive nerve and the facial nerve</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARNOLD, A</creatorcontrib><creatorcontrib>EHRENBERGER, K</creatorcontrib><creatorcontrib>FRENZ, M</creatorcontrib><creatorcontrib>PRATISTO, H</creatorcontrib><creatorcontrib>WEBER, H. P</creatorcontrib><creatorcontrib>ALTERMATT, H. J</creatorcontrib><creatorcontrib>FELIX, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARNOLD, A</au><au>EHRENBERGER, K</au><au>FRENZ, M</au><au>PRATISTO, H</au><au>WEBER, H. P</au><au>ALTERMATT, H. J</au><au>FELIX, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental erbium laser surgery in the guinea pig cochlea : its use in the study of afferent cochlear neurotransmitters</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>1996</date><risdate>1996</risdate><volume>253</volume><issue>8</issue><spage>460</spage><epage>463</epage><pages>460-463</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Microiontophoretic techniques were used to examine the changes in activity of inner half cell afferents in the guinea pig following circumscribed penetration of cochlear bone with erbium:YSGG laser pulses. Neuronal responses to the application of the glutamate agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) before laser use and after return to normal spontaneous activity were equivalent, implying total reversibility of the changes occurring. Suppression of laser-induced hair cell activity was possible with NMDA and AMPA receptor antagonists and lasted 10-15 min. These findings suggest a transmitter-related increase of neuronal activity. Our results show that use of the erbium laser in inner ear microsurgery might be possible with low risk if the amount of energy applied is kept under a safe limit of 10 J/cm2.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9044567</pmid><doi>10.1007/BF00179950</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 1996, Vol.253 (8), p.460-463 |
| issn | 0937-4477 1434-4726 |
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| subjects | 6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage Animals Biological and medical sciences Cochlea - drug effects Cochlea - physiology Cochlea - surgery Erbium Excitatory Amino Acid Agonists - administration & dosage Excitatory Amino Acid Antagonists - administration & dosage Female Guinea Pigs Hair Cells, Auditory, Inner - drug effects Hair Cells, Auditory, Inner - physiology Hair Cells, Auditory, Inner - radiation effects Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Iontophoresis Laser Therapy Male Medical sciences Microelectrodes N-Methylaspartate - administration & dosage Neurotransmitter Agents - physiology Neurotransmitter Agents - radiation effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the ear, the auditive nerve and the facial nerve Synaptic Transmission - drug effects Synaptic Transmission - radiation effects |
| title | Experimental erbium laser surgery in the guinea pig cochlea : its use in the study of afferent cochlear neurotransmitters |
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