Antiarrhythmic effects of HOE642, a novel Na +-H + exchange inhibitor, on ventricular arrhythmias in animal hearts

HOE642 (4-isopropyl-3-methylsulphonylbenzoyl-guanidine methanesulphonate), a novel Na +-H + exchange subtype 1 inhibitor, was investigated for its possible antiarrhythmic effects on coronary artery ligation/reperfusion and ouabain-induced arrhythmias in the canine heart which may occur after intrace...

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Veröffentlicht in:	European journal of pharmacology 1996-12, Vol.317 (2), p.309-316
Hauptverfasser:	Xue, Yi Xue, Aye, Nu Nu, Hashimoto, Keitaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacology Arrhythmia ischemia Arrhythmia reperfusion Cardiotonic Agents Coronary Vessels - physiology Digitalis arrhythmia Digitalis Glycosides Dogs Dose-Response Relationship, Drug Female Guanidines - blood Guanidines - pharmacology HOE642 Injections, Intravenous Male Myocardial Ischemia - physiopathology Myocardial Reperfusion Injury - physiopathology Na +/Ca 2+ exchange Na +/H + exchange Rats Rats, Sprague-Dawley Sodium-Hydrogen Exchangers - antagonists & inhibitors Sulfones - blood Sulfones - pharmacology Ventricular Fibrillation - etiology Ventricular Fibrillation - physiopathology Ventricular Fibrillation - prevention & control
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