DNA strand breakage by 125I-decay in a synthetic oligodeoxynucleotide--2. Quantitative analysis of fragment distribution

The DNA breakage produced by decay of 125I in a double-stranded 41 bp oligodeoxynucleotide was investigated by DNA sequencing gel analysis. Use of both 5'- and 3'-end 32P labelling of the 125I containing strand provided the single-stranded breakage pattern at either side of the 125I-dC. Th...

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Veröffentlicht in:	Acta oncologica 1996, Vol.35 (7), p.809-815
Hauptverfasser:	Lobachevsky, P N, Martin, R F
Format:	Artikel
Sprache:	eng
Schlagworte:	Dimethyl Sulfoxide - pharmacology DNA - drug effects DNA - radiation effects DNA Damage Iodine Radioisotopes Linear Energy Transfer Nucleotides - radiation effects Space life sciences
Online-Zugang:	Volltext
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