CLINICAL ASSOCIATIONS OF DUAL-ENERGY X-RAY ABSORPTIOMETRY MEASUREMENT OF HAND BONE MASS IN RHEUMATOID ARTHRITIS
Hand bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DXA) has potential as a marker of progression in early rheumatoid arthritis (RA). We examined a DXA methodology and studied in a cross-sectional manner 202 patients with RA. Hand BMD correlated inversely with age and wa...
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| Veröffentlicht in: | British journal of rheumatology 1996-12, Vol.35 (12), p.1256-1262 |
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| container_title | British journal of rheumatology |
| container_volume | 35 |
| creator | DEVLIN, J. LILLEY, J. GOUGH, A. HUISSOON, A. HOLDER, R. REECE, R. PERKINS, P. EMERY, P. |
| description | Hand bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DXA) has potential as a marker of progression in early rheumatoid arthritis (RA). We examined a DXA methodology and studied in a cross-sectional manner 202 patients with RA. Hand BMD correlated inversely with age and was higher in males. Hand BMD correlated with lumbar and femoral sites. In females, BMD of the hand correlated positively with grip strength and negatively with disability. Those with higher C-reactive protein (CRP) had significantly lower hand BMD than those with normal CRP. In patients with a normal CRP, the hand BMD:lumbar BMD ratios were significantly higher in patients with longer disease duration. Hand BMD correlates with measures of disease activity, functional capacity and also with lumbar and femoral BMD. Hand bone loss occurs in early disease, in the absence of detectable systemic disease, and before lumbar BMD loss. It has the potential to be an outcome measure in early disease |
| doi_str_mv | 10.1093/rheumatology/35.12.1256 |
| format | Article |
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We examined a DXA methodology and studied in a cross-sectional manner 202 patients with RA. Hand BMD correlated inversely with age and was higher in males. Hand BMD correlated with lumbar and femoral sites. In females, BMD of the hand correlated positively with grip strength and negatively with disability. Those with higher C-reactive protein (CRP) had significantly lower hand BMD than those with normal CRP. In patients with a normal CRP, the hand BMD:lumbar BMD ratios were significantly higher in patients with longer disease duration. Hand BMD correlates with measures of disease activity, functional capacity and also with lumbar and femoral BMD. Hand bone loss occurs in early disease, in the absence of detectable systemic disease, and before lumbar BMD loss. 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We examined a DXA methodology and studied in a cross-sectional manner 202 patients with RA. Hand BMD correlated inversely with age and was higher in males. Hand BMD correlated with lumbar and femoral sites. In females, BMD of the hand correlated positively with grip strength and negatively with disability. Those with higher C-reactive protein (CRP) had significantly lower hand BMD than those with normal CRP. In patients with a normal CRP, the hand BMD:lumbar BMD ratios were significantly higher in patients with longer disease duration. Hand BMD correlates with measures of disease activity, functional capacity and also with lumbar and femoral BMD. Hand bone loss occurs in early disease, in the absence of detectable systemic disease, and before lumbar BMD loss. It has the potential to be an outcome measure in early disease</description><subject>Absorptiometry, Photon</subject><subject>Acute-Phase Reaction</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Bone Density</subject><subject>Cadaver</subject><subject>Diseases of the osteoarticular system</subject><subject>DXA</subject><subject>Female</subject><subject>Femur - diagnostic imaging</subject><subject>Hand</subject><subject>Hand - diagnostic imaging</subject><subject>Hand - physiopathology</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Rheumatoid arthritis</subject><issn>1462-0324</issn><issn>0263-7103</issn><issn>1460-2172</issn><issn>1462-0332</issn><issn>1460-2172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1r2zAUhs1Y6bpuP2FMjNE7t_qwLOlSTdzY4I_NdkazG-HK8pbOiVsrhvXfVyEhjMGBc-B9zss5vJ73GcFrBAW5GX-badPshn749XJD6DXCrmj4xrtAQYh9SAh-e5px8M57b-0jhJAiws-9cwGRm8mFN8zSJE9mMgWyqopZIuukyCtQ3IH5UqZ-lEflYgXu_VKugLytivKbA7KoLlcgi2S1LKMsyus9H8t8Dm6LPAKZswJJDso4WmayLpI5kGUdl0mdVB-8s67prfl47Jfe8i6qZ7GfFov9Gb6mQbjzBSYEQsQhRq2mhGrKNNLBQ8sF7LgwDaM0oKRz3zBMkYCMdYEQ0KC2NcxoculdHXyfxuF5MnanNmurTd83WzNMVjEe8oBz6MAv_4GPwzRu3W0KCRoyDhl2EDtAehysHU2nnsb1phlfFIJqn4f6Nw9FqEJY7fNwm5-O9tPDxrSnvWMATv961Burm74bm61e2xOGacApQQ7zD9ja7szfk9yMf1TICKMqvv-pFumixtkPqr6TV5iTm2c</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>DEVLIN, J.</creator><creator>LILLEY, J.</creator><creator>GOUGH, A.</creator><creator>HUISSOON, A.</creator><creator>HOLDER, R.</creator><creator>REECE, R.</creator><creator>PERKINS, P.</creator><creator>EMERY, P.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>CLINICAL ASSOCIATIONS OF DUAL-ENERGY X-RAY ABSORPTIOMETRY MEASUREMENT OF HAND BONE MASS IN RHEUMATOID ARTHRITIS</title><author>DEVLIN, J. ; LILLEY, J. ; GOUGH, A. ; HUISSOON, A. ; HOLDER, R. ; REECE, R. ; PERKINS, P. ; EMERY, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-92330018021dc535c57c1c4bd890f89ea755453f13872519077f4990e1dde7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Absorptiometry, Photon</topic><topic>Acute-Phase Reaction</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Bone Density</topic><topic>Cadaver</topic><topic>Diseases of the osteoarticular system</topic><topic>DXA</topic><topic>Female</topic><topic>Femur - diagnostic imaging</topic><topic>Hand</topic><topic>Hand - diagnostic imaging</topic><topic>Hand - physiopathology</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Rheumatoid arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEVLIN, J.</creatorcontrib><creatorcontrib>LILLEY, J.</creatorcontrib><creatorcontrib>GOUGH, A.</creatorcontrib><creatorcontrib>HUISSOON, A.</creatorcontrib><creatorcontrib>HOLDER, R.</creatorcontrib><creatorcontrib>REECE, R.</creatorcontrib><creatorcontrib>PERKINS, P.</creatorcontrib><creatorcontrib>EMERY, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEVLIN, J.</au><au>LILLEY, J.</au><au>GOUGH, A.</au><au>HUISSOON, A.</au><au>HOLDER, R.</au><au>REECE, R.</au><au>PERKINS, P.</au><au>EMERY, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CLINICAL ASSOCIATIONS OF DUAL-ENERGY X-RAY ABSORPTIOMETRY MEASUREMENT OF HAND BONE MASS IN RHEUMATOID ARTHRITIS</atitle><jtitle>British journal of rheumatology</jtitle><addtitle>Br J Rheumatol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>35</volume><issue>12</issue><spage>1256</spage><epage>1262</epage><pages>1256-1262</pages><issn>1462-0324</issn><issn>0263-7103</issn><issn>1460-2172</issn><eissn>1462-0332</eissn><eissn>1460-2172</eissn><coden>BJRHDF</coden><abstract>Hand bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DXA) has potential as a marker of progression in early rheumatoid arthritis (RA). We examined a DXA methodology and studied in a cross-sectional manner 202 patients with RA. Hand BMD correlated inversely with age and was higher in males. Hand BMD correlated with lumbar and femoral sites. In females, BMD of the hand correlated positively with grip strength and negatively with disability. Those with higher C-reactive protein (CRP) had significantly lower hand BMD than those with normal CRP. In patients with a normal CRP, the hand BMD:lumbar BMD ratios were significantly higher in patients with longer disease duration. Hand BMD correlates with measures of disease activity, functional capacity and also with lumbar and femoral BMD. Hand bone loss occurs in early disease, in the absence of detectable systemic disease, and before lumbar BMD loss. It has the potential to be an outcome measure in early disease</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9010053</pmid><doi>10.1093/rheumatology/35.12.1256</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon Acute-Phase Reaction Adult Aged Aged, 80 and over Arthritis, Rheumatoid - diagnostic imaging Biological and medical sciences Bone Density Cadaver Diseases of the osteoarticular system DXA Female Femur - diagnostic imaging Hand Hand - diagnostic imaging Hand - physiopathology Humans Inflammatory joint diseases Lumbar Vertebrae - diagnostic imaging Male Medical sciences Middle Aged Rheumatoid arthritis |
| title | CLINICAL ASSOCIATIONS OF DUAL-ENERGY X-RAY ABSORPTIOMETRY MEASUREMENT OF HAND BONE MASS IN RHEUMATOID ARTHRITIS |
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