Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study

Chlorocycloguanil, the active metabolite of chlorproguanil, was synergistic in vitro with dapsone against 2 culture-adapted Plasmodium falciparum isolates from Kenya; maximal synergy occurred at lower concentrations that it did with pyrimethamine and sulfadoxine. 48 children with asymptomatic P. fal...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 1988, Vol.82 (3), p.398-403
Hauptverfasser:	Watkins, W.M., Brandling-Bennett, A.D., Nevill, C.G., Carter, J.Y., Boriga, D.A., Howells, R.E., Koech, D.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Dapsone - therapeutic use Drug Therapy, Combination Human protozoal diseases Humans Infectious diseases Kenya Malaria Malaria - drug therapy Medical sciences Parasitic diseases Pharmacology. Drug treatments Pilot Projects Plasmodium falciparum Proguanil - analogs & derivatives Proguanil - therapeutic use Protozoal diseases Tropical medicine
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