EGF responsiveness of hepatocytes after partial hepatectomy
We investigate the effect of EGF on IP 3 production, PLCγ phosphorylation, calcium transients in rat hepatocytes isolated in quiescent liver (G 0 phase of cell cycle) and at 4 h (G 1 phase of cell cycle) and 24 h (M phase of cell cycle) after partial hepatectomy. Our results show that EGF does not u...
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| Veröffentlicht in: | Cellular signalling 1996-12, Vol.8 (8), p.555-559 |
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| creator | Marino, Maria Spagnuolo, Silvana Cavallini, Matteo Terenzi, Fulvia Mangiantini, Maria Teresa Leoni, Silvia |
| description | We investigate the effect of EGF on IP
3 production, PLCγ phosphorylation, calcium transients in rat hepatocytes isolated in quiescent liver (G
0 phase of cell cycle) and at 4 h (G
1 phase of cell cycle) and 24 h (M phase of cell cycle) after partial hepatectomy. Our results show that EGF does not utilize IP
3 and calcium as its signal transduction molecules when the hepatocytes are
in vivo stimulated to entry in the cell cycle. In particular the growth factor does not phosphorylate PLCγ and induces a decrease in IP
3 content. These data suggest that EGF utilizes different signal transduction to send information from receptor to nucleus during PH with respect to the quiescent liver. |
| doi_str_mv | 10.1016/S0898-6568(96)00111-8 |
| format | Article |
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3 production, PLCγ phosphorylation, calcium transients in rat hepatocytes isolated in quiescent liver (G
0 phase of cell cycle) and at 4 h (G
1 phase of cell cycle) and 24 h (M phase of cell cycle) after partial hepatectomy. Our results show that EGF does not utilize IP
3 and calcium as its signal transduction molecules when the hepatocytes are
in vivo stimulated to entry in the cell cycle. In particular the growth factor does not phosphorylate PLCγ and induces a decrease in IP
3 content. These data suggest that EGF utilizes different signal transduction to send information from receptor to nucleus during PH with respect to the quiescent liver.</description><identifier>ISSN: 0898-6568</identifier><identifier>EISSN: 1873-3913</identifier><identifier>DOI: 10.1016/S0898-6568(96)00111-8</identifier><identifier>PMID: 9115847</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Calcium - metabolism ; Calcium transients ; Cell Cycle ; Epidermal Growth Factor - pharmacology ; Growth factor ; Hepatectomy ; Inositol 1,4,5-Trisphosphate - biosynthesis ; Inositol phosphates metabolism ; Isoenzymes - metabolism ; Kinetics ; Liver - cytology ; Liver - drug effects ; Liver - metabolism ; Male ; Partial hepatectomy (rat hepatocytes) ; Phospholipase C gamma ; PLCγ ; Rats ; Second Messenger Systems - drug effects ; Signal transduction ; Signal Transduction - drug effects ; Type C Phospholipases - metabolism</subject><ispartof>Cellular signalling, 1996-12, Vol.8 (8), p.555-559</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-7198e1abed5bb3b7db08307e2360590d947bec5cb46e37c969fe72fcb7312fc33</citedby><cites>FETCH-LOGICAL-c391t-7198e1abed5bb3b7db08307e2360590d947bec5cb46e37c969fe72fcb7312fc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0898-6568(96)00111-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9115847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marino, Maria</creatorcontrib><creatorcontrib>Spagnuolo, Silvana</creatorcontrib><creatorcontrib>Cavallini, Matteo</creatorcontrib><creatorcontrib>Terenzi, Fulvia</creatorcontrib><creatorcontrib>Mangiantini, Maria Teresa</creatorcontrib><creatorcontrib>Leoni, Silvia</creatorcontrib><title>EGF responsiveness of hepatocytes after partial hepatectomy</title><title>Cellular signalling</title><addtitle>Cell Signal</addtitle><description>We investigate the effect of EGF on IP
3 production, PLCγ phosphorylation, calcium transients in rat hepatocytes isolated in quiescent liver (G
0 phase of cell cycle) and at 4 h (G
1 phase of cell cycle) and 24 h (M phase of cell cycle) after partial hepatectomy. Our results show that EGF does not utilize IP
3 and calcium as its signal transduction molecules when the hepatocytes are
in vivo stimulated to entry in the cell cycle. In particular the growth factor does not phosphorylate PLCγ and induces a decrease in IP
3 content. These data suggest that EGF utilizes different signal transduction to send information from receptor to nucleus during PH with respect to the quiescent liver.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium transients</subject><subject>Cell Cycle</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Growth factor</subject><subject>Hepatectomy</subject><subject>Inositol 1,4,5-Trisphosphate - biosynthesis</subject><subject>Inositol phosphates metabolism</subject><subject>Isoenzymes - metabolism</subject><subject>Kinetics</subject><subject>Liver - cytology</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Partial hepatectomy (rat hepatocytes)</subject><subject>Phospholipase C gamma</subject><subject>PLCγ</subject><subject>Rats</subject><subject>Second Messenger Systems - drug effects</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Type C Phospholipases - metabolism</subject><issn>0898-6568</issn><issn>1873-3913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9Lw0AQxRdRaq1-hEJOoofoTjbZP3gQKW0VCh7U85LdTDCSdONuWui3N21Kr57e4b2ZN_MjZAr0ASjwxw8qlYx5xuWd4veUAkAsz8gYpGAxU8DOyfgUuSRXIfz0oYzyZERGCiCTqRiTp_lyEXkMrVuHaotrDCFyZfSNbd45u-swRHnZoY_a3HdVXg8O2s41u2tyUeZ1wJujTsjXYv45e41X78u32csqtv0ZXSxASYTcYJEZw4woDJWMCkwYp5mihUqFQZtZk3JkwiquShRJaY1g0AtjE3I77G29-91g6HRTBYt1na_RbYIWkgsJNP032P8MkCb7jdkQtN6F4LHUra-a3O80UL2nqw909R6dVlwf6GrZz02PBRvTYHGaOuLs_efBxx7HtkKvg61wbbGofM9MF676p-EPJhuJqw</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Marino, Maria</creator><creator>Spagnuolo, Silvana</creator><creator>Cavallini, Matteo</creator><creator>Terenzi, Fulvia</creator><creator>Mangiantini, Maria Teresa</creator><creator>Leoni, Silvia</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>EGF responsiveness of hepatocytes after partial hepatectomy</title><author>Marino, Maria ; Spagnuolo, Silvana ; Cavallini, Matteo ; Terenzi, Fulvia ; Mangiantini, Maria Teresa ; Leoni, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-7198e1abed5bb3b7db08307e2360590d947bec5cb46e37c969fe72fcb7312fc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Calcium transients</topic><topic>Cell Cycle</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Growth factor</topic><topic>Hepatectomy</topic><topic>Inositol 1,4,5-Trisphosphate - biosynthesis</topic><topic>Inositol phosphates metabolism</topic><topic>Isoenzymes - metabolism</topic><topic>Kinetics</topic><topic>Liver - cytology</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Partial hepatectomy (rat hepatocytes)</topic><topic>Phospholipase C gamma</topic><topic>PLCγ</topic><topic>Rats</topic><topic>Second Messenger Systems - drug effects</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Type C Phospholipases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marino, Maria</creatorcontrib><creatorcontrib>Spagnuolo, Silvana</creatorcontrib><creatorcontrib>Cavallini, Matteo</creatorcontrib><creatorcontrib>Terenzi, Fulvia</creatorcontrib><creatorcontrib>Mangiantini, Maria Teresa</creatorcontrib><creatorcontrib>Leoni, Silvia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular signalling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marino, Maria</au><au>Spagnuolo, Silvana</au><au>Cavallini, Matteo</au><au>Terenzi, Fulvia</au><au>Mangiantini, Maria Teresa</au><au>Leoni, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EGF responsiveness of hepatocytes after partial hepatectomy</atitle><jtitle>Cellular signalling</jtitle><addtitle>Cell Signal</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>8</volume><issue>8</issue><spage>555</spage><epage>559</epage><pages>555-559</pages><issn>0898-6568</issn><eissn>1873-3913</eissn><abstract>We investigate the effect of EGF on IP
3 production, PLCγ phosphorylation, calcium transients in rat hepatocytes isolated in quiescent liver (G
0 phase of cell cycle) and at 4 h (G
1 phase of cell cycle) and 24 h (M phase of cell cycle) after partial hepatectomy. Our results show that EGF does not utilize IP
3 and calcium as its signal transduction molecules when the hepatocytes are
in vivo stimulated to entry in the cell cycle. In particular the growth factor does not phosphorylate PLCγ and induces a decrease in IP
3 content. These data suggest that EGF utilizes different signal transduction to send information from receptor to nucleus during PH with respect to the quiescent liver.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>9115847</pmid><doi>10.1016/S0898-6568(96)00111-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cellular signalling, 1996-12, Vol.8 (8), p.555-559 |
| issn | 0898-6568 1873-3913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Calcium - metabolism Calcium transients Cell Cycle Epidermal Growth Factor - pharmacology Growth factor Hepatectomy Inositol 1,4,5-Trisphosphate - biosynthesis Inositol phosphates metabolism Isoenzymes - metabolism Kinetics Liver - cytology Liver - drug effects Liver - metabolism Male Partial hepatectomy (rat hepatocytes) Phospholipase C gamma PLCγ Rats Second Messenger Systems - drug effects Signal transduction Signal Transduction - drug effects Type C Phospholipases - metabolism |
| title | EGF responsiveness of hepatocytes after partial hepatectomy |
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