Requirement of Calcium Influx for Hydrolytic Action of Membrane Phospholipids by Cytosolic Phospholipase A2 Rather than Mitogen-Activated Protein Kinase Activation in FcεRI-Stimulated Rat Peritoneal Mast Cells

The mechanism by which cytosolic phospholipase A2 (cPLA2 is not responsible for eicosanoid production in rat peritoneal mast cells upon antigen stimulation [Ishimoto et al (1996) J. Biochem. 120, 616–623] was investigated in the mast cells stimulated by crosslinking of the IgE receptor or with thaps...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1996-12, Vol.120 (6), p.1247-1252
Hauptverfasser:	Ishimoto, Tsuyoshi, Arisato, Kyoichi, Sato, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cytosol - metabolism cytosolic phospholipase A2 Dinitrophenols - pharmacology Enzyme Activation intracellular calcium concentration lysophosphatidylcholine Lysophosphatidylcholines - metabolism mast cell Mast Cells - drug effects Mast Cells - metabolism Membrane Lipids - metabolism mitogen-activated protein kinase Phospholipases A - metabolism Phospholipases A2 Phospholipids - metabolism Rats Receptors, IgE - metabolism Serum Albumin, Bovine - pharmacology Thapsigargin - pharmacology
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