Enhancement of in vivo production of IL-1α and IL-6 in mice by Y-25510, a 1H-pyrazolo[3,4-b]pyridine-1-acetic acid derivative

The serum concentrations of interleukin(IL)-lα and IL-6 in C57BL/6 and C3H/HeN mice reached the maximum at 12–16h after the intravenous treatment with (±)-3-[4-(2-dimethylamino-l-methylethoxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-1-acetic acid (Y-25510) at a dose of 3 mg/kg, and the concentration of I...

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