Transdermally administered nicotine accumulates in gastric juice
Transdermal nicotine patches (Nicorette 15 mg.16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma. Nicotine accumulated in gastric juice, the average concentration being 60...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical pharmacology 1996, Vol.51 (3-4), p.315-318 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 318 |
|---|---|
| container_issue | 3-4 |
| container_start_page | 315 |
| container_title | European journal of clinical pharmacology |
| container_volume | 51 |
| creator | LINDELL, G LUNELL, E GRAFFNER, H |
| description | Transdermal nicotine patches (Nicorette 15 mg.16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma.
Nicotine accumulated in gastric juice, the average concentration being 60.6-times higher than in plasma. In saliva, too, the concentration was higher than in plasma, the average ratio being 10.5. These results strongly suggested ion-trapping of nicotine base in the acidic gastric juice and possibly also in the acinar cells, followed by active secretion. It is hypothesised that accumulation in saliva occurs via a similar mechanism. Pretreatment with omeprazole did not increase the pH to a sufficiently high degree to test the hypothesis that the accumulation of nicotine in gastric juice was pH dependent.
Transdermal administration of nicotine produced a high intragastric concentration. The clinical consequence of this effect of long-term nicotine replacement therapy during smoking cessation is unclear. |
| doi_str_mv | 10.1007/s002280050204 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78677219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78677219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c317t-da0bbcaa7f8a856d02bca9a7503b640aea7f4cfaee19d5fa692d92e2246767813</originalsourceid><addsrcrecordid>eNpVkM1LxDAQR4Mo67p69Cj0IN6qk7RNmpuy-AULXtZzmSZTyZK2a9Ie9r-3skXwNAzv8Ts8xq453HMA9RABhCgBChCQn7AlzzORcsj5KVsCZDyVWsE5u4hxB8ALDdmCLTRwUFAs2eM2YBcthRa9PyRoW9e5OFAgm3TO9IPrKEFjxnb0OFBMXJd8YRyCM8ludIYu2VmDPtLVfFfs8-V5u35LNx-v7-unTWoyrobUItS1QVRNiWUhLYjp06gKyGqZA9JEctMgEde2aFBqYbUgIXKppCp5tmJ3x9196L9HikPVumjIe-yoH2OlSqmU4HoS06NoQh9joKbaB9diOFQcqt9i1b9ik38zD491S_bPnhNN_HbmGA36ZuplXPzTRME1l5D9APl5c0k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78677219</pqid></control><display><type>article</type><title>Transdermally administered nicotine accumulates in gastric juice</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>LINDELL, G ; LUNELL, E ; GRAFFNER, H</creator><creatorcontrib>LINDELL, G ; LUNELL, E ; GRAFFNER, H</creatorcontrib><description>Transdermal nicotine patches (Nicorette 15 mg.16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma.
Nicotine accumulated in gastric juice, the average concentration being 60.6-times higher than in plasma. In saliva, too, the concentration was higher than in plasma, the average ratio being 10.5. These results strongly suggested ion-trapping of nicotine base in the acidic gastric juice and possibly also in the acinar cells, followed by active secretion. It is hypothesised that accumulation in saliva occurs via a similar mechanism. Pretreatment with omeprazole did not increase the pH to a sufficiently high degree to test the hypothesis that the accumulation of nicotine in gastric juice was pH dependent.
Transdermal administration of nicotine produced a high intragastric concentration. The clinical consequence of this effect of long-term nicotine replacement therapy during smoking cessation is unclear.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s002280050204</identifier><identifier>PMID: 9010705</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Administration, Cutaneous ; Adult ; Biological and medical sciences ; Female ; Gastric Acidity Determination ; Gastric Juice - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Nicotine - administration & dosage ; Nicotine - pharmacokinetics ; Saliva - metabolism ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>European journal of clinical pharmacology, 1996, Vol.51 (3-4), p.315-318</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-da0bbcaa7f8a856d02bca9a7503b640aea7f4cfaee19d5fa692d92e2246767813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2519160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9010705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LINDELL, G</creatorcontrib><creatorcontrib>LUNELL, E</creatorcontrib><creatorcontrib>GRAFFNER, H</creatorcontrib><title>Transdermally administered nicotine accumulates in gastric juice</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Transdermal nicotine patches (Nicorette 15 mg.16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma.
Nicotine accumulated in gastric juice, the average concentration being 60.6-times higher than in plasma. In saliva, too, the concentration was higher than in plasma, the average ratio being 10.5. These results strongly suggested ion-trapping of nicotine base in the acidic gastric juice and possibly also in the acinar cells, followed by active secretion. It is hypothesised that accumulation in saliva occurs via a similar mechanism. Pretreatment with omeprazole did not increase the pH to a sufficiently high degree to test the hypothesis that the accumulation of nicotine in gastric juice was pH dependent.
Transdermal administration of nicotine produced a high intragastric concentration. The clinical consequence of this effect of long-term nicotine replacement therapy during smoking cessation is unclear.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastric Acidity Determination</subject><subject>Gastric Juice - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - pharmacokinetics</subject><subject>Saliva - metabolism</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LxDAQR4Mo67p69Cj0IN6qk7RNmpuy-AULXtZzmSZTyZK2a9Ie9r-3skXwNAzv8Ts8xq453HMA9RABhCgBChCQn7AlzzORcsj5KVsCZDyVWsE5u4hxB8ALDdmCLTRwUFAs2eM2YBcthRa9PyRoW9e5OFAgm3TO9IPrKEFjxnb0OFBMXJd8YRyCM8ludIYu2VmDPtLVfFfs8-V5u35LNx-v7-unTWoyrobUItS1QVRNiWUhLYjp06gKyGqZA9JEctMgEde2aFBqYbUgIXKppCp5tmJ3x9196L9HikPVumjIe-yoH2OlSqmU4HoS06NoQh9joKbaB9diOFQcqt9i1b9ik38zD491S_bPnhNN_HbmGA36ZuplXPzTRME1l5D9APl5c0k</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>LINDELL, G</creator><creator>LUNELL, E</creator><creator>GRAFFNER, H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Transdermally administered nicotine accumulates in gastric juice</title><author>LINDELL, G ; LUNELL, E ; GRAFFNER, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-da0bbcaa7f8a856d02bca9a7503b640aea7f4cfaee19d5fa692d92e2246767813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastric Acidity Determination</topic><topic>Gastric Juice - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotine - pharmacokinetics</topic><topic>Saliva - metabolism</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LINDELL, G</creatorcontrib><creatorcontrib>LUNELL, E</creatorcontrib><creatorcontrib>GRAFFNER, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LINDELL, G</au><au>LUNELL, E</au><au>GRAFFNER, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transdermally administered nicotine accumulates in gastric juice</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1996</date><risdate>1996</risdate><volume>51</volume><issue>3-4</issue><spage>315</spage><epage>318</epage><pages>315-318</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Transdermal nicotine patches (Nicorette 15 mg.16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma.
Nicotine accumulated in gastric juice, the average concentration being 60.6-times higher than in plasma. In saliva, too, the concentration was higher than in plasma, the average ratio being 10.5. These results strongly suggested ion-trapping of nicotine base in the acidic gastric juice and possibly also in the acinar cells, followed by active secretion. It is hypothesised that accumulation in saliva occurs via a similar mechanism. Pretreatment with omeprazole did not increase the pH to a sufficiently high degree to test the hypothesis that the accumulation of nicotine in gastric juice was pH dependent.
Transdermal administration of nicotine produced a high intragastric concentration. The clinical consequence of this effect of long-term nicotine replacement therapy during smoking cessation is unclear.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>9010705</pmid><doi>10.1007/s002280050204</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1996, Vol.51 (3-4), p.315-318 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78677219 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Administration, Cutaneous Adult Biological and medical sciences Female Gastric Acidity Determination Gastric Juice - metabolism Humans Male Medical sciences Middle Aged Nicotine - administration & dosage Nicotine - pharmacokinetics Saliva - metabolism Tobacco, tobacco smoking Toxicology |
| title | Transdermally administered nicotine accumulates in gastric juice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T20%3A47%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transdermally%20administered%20nicotine%20accumulates%20in%20gastric%20juice&rft.jtitle=European%20journal%20of%20clinical%20pharmacology&rft.au=LINDELL,%20G&rft.date=1996&rft.volume=51&rft.issue=3-4&rft.spage=315&rft.epage=318&rft.pages=315-318&rft.issn=0031-6970&rft.eissn=1432-1041&rft_id=info:doi/10.1007/s002280050204&rft_dat=%3Cproquest_cross%3E78677219%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78677219&rft_id=info:pmid/9010705&rfr_iscdi=true |