Biology of African trypanosomes in the tsetse fly [mitochondrion, variable antigen coat, flagellar attachment]
African trypanosomes present several features of interest to cell biologists. These include: a repressible single mitochondrion with a large mass of mitochondrial DNA, the kinetoplast; a special organelle, the glycosome, which houses the enzymes of the glycolytic chain; a surface coat of variable gl...
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| Veröffentlicht in: | Biology of the cell 1988, Vol.64 (2), p.109-119 |
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| container_title | Biology of the cell |
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| creator | Vickerman, K. (University of Glasgow (UK). Department of Zoology) Tetley, L Hendry, A.K Turner, M.R |
| description | African trypanosomes present several features of interest to cell biologists. These include: a repressible single mitochondrion with a large mass of mitochondrial DNA, the kinetoplast; a special organelle, the glycosome, which houses the enzymes of the glycolytic chain; a surface coat of variable glycoprotein which enables the parasite to evade the mammalian host's immune response; and a unique flagellum‐to‐host attachment mechanism associated with novel cytoskeletal elements. Trypanosome development during the life cycle involves cyclical activation and repression of genes controlling these activities. Understanding the complexity of parasite development in the tsetse fly vector is especially challenging but may help to suggest new methods for the control of trypanosomiasis. |
| doi_str_mv | 10.1016/0248-4900(88)90070-6 |
| format | Article |
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(University of Glasgow (UK). Department of Zoology) ; Tetley, L ; Hendry, A.K ; Turner, M.R</creator><creatorcontrib>Vickerman, K. (University of Glasgow (UK). Department of Zoology) ; Tetley, L ; Hendry, A.K ; Turner, M.R</creatorcontrib><description>African trypanosomes present several features of interest to cell biologists. These include: a repressible single mitochondrion with a large mass of mitochondrial DNA, the kinetoplast; a special organelle, the glycosome, which houses the enzymes of the glycolytic chain; a surface coat of variable glycoprotein which enables the parasite to evade the mammalian host's immune response; and a unique flagellum‐to‐host attachment mechanism associated with novel cytoskeletal elements. Trypanosome development during the life cycle involves cyclical activation and repression of genes controlling these activities. Understanding the complexity of parasite development in the tsetse fly vector is especially challenging but may help to suggest new methods for the control of trypanosomiasis.</description><identifier>ISSN: 0248-4900</identifier><identifier>EISSN: 1768-322X</identifier><identifier>DOI: 10.1016/0248-4900(88)90070-6</identifier><identifier>PMID: 3067793</identifier><identifier>CODEN: BCELDF</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ANIMAL DISEASES ; Animals ; Biological and medical sciences ; CICLO VITAL ; CYCLE DE DEVELOPPEMENT ; ENFERMEDADES DE LOS ANIMALES ; flagellar attachment ; Fundamental and applied biological sciences. Psychology ; GLOSSINIDAE ; Host-Parasite Interactions ; LIFE CYCLE ; MALADIE DES ANIMAUX ; MICROBIAL PROPERTIES ; mitochondrion ; PODER MICROBIANO ; PROPRIETE DES MICROORGANISMES ; Protozoa ; TRYPANOSOMA ; Trypanosoma - physiology ; trypanosome ; Tsetse Flies - parasitology ; ULTRAESTRUCTURA ; ULTRASTRUCTURE ; variable antigen coat ; VECTEUR ; VECTORES ; VECTORS ; ZOONOSE ; ZOONOSES ; ZOONOSIS</subject><ispartof>Biology of the cell, 1988, Vol.64 (2), p.109-119</ispartof><rights>1988 Société Française des Microscopies and Société Biologie Cellulaire de France</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5058-8e51baf72c824776b1f9f65d6592d0b682d7e454c1f2053303376824e4d5e40e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23909,23910,25118,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19799527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3067793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vickerman, K. (University of Glasgow (UK). Department of Zoology)</creatorcontrib><creatorcontrib>Tetley, L</creatorcontrib><creatorcontrib>Hendry, A.K</creatorcontrib><creatorcontrib>Turner, M.R</creatorcontrib><title>Biology of African trypanosomes in the tsetse fly [mitochondrion, variable antigen coat, flagellar attachment]</title><title>Biology of the cell</title><addtitle>Biol Cell</addtitle><description>African trypanosomes present several features of interest to cell biologists. These include: a repressible single mitochondrion with a large mass of mitochondrial DNA, the kinetoplast; a special organelle, the glycosome, which houses the enzymes of the glycolytic chain; a surface coat of variable glycoprotein which enables the parasite to evade the mammalian host's immune response; and a unique flagellum‐to‐host attachment mechanism associated with novel cytoskeletal elements. Trypanosome development during the life cycle involves cyclical activation and repression of genes controlling these activities. Understanding the complexity of parasite development in the tsetse fly vector is especially challenging but may help to suggest new methods for the control of trypanosomiasis.</description><subject>ANIMAL DISEASES</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CICLO VITAL</subject><subject>CYCLE DE DEVELOPPEMENT</subject><subject>ENFERMEDADES DE LOS ANIMALES</subject><subject>flagellar attachment</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLOSSINIDAE</subject><subject>Host-Parasite Interactions</subject><subject>LIFE CYCLE</subject><subject>MALADIE DES ANIMAUX</subject><subject>MICROBIAL PROPERTIES</subject><subject>mitochondrion</subject><subject>PODER MICROBIANO</subject><subject>PROPRIETE DES MICROORGANISMES</subject><subject>Protozoa</subject><subject>TRYPANOSOMA</subject><subject>Trypanosoma - physiology</subject><subject>trypanosome</subject><subject>Tsetse Flies - parasitology</subject><subject>ULTRAESTRUCTURA</subject><subject>ULTRASTRUCTURE</subject><subject>variable antigen coat</subject><subject>VECTEUR</subject><subject>VECTORES</subject><subject>VECTORS</subject><subject>ZOONOSE</subject><subject>ZOONOSES</subject><subject>ZOONOSIS</subject><issn>0248-4900</issn><issn>1768-322X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1rFDEUhgdR6lr9A6KQG6VCR5NMPi-7S1uF2mLxC0RCJpPsRmcmazKrzr834yzrrRA4hPO8JydPUTxB8CWCiL2CmIiSSAhPhHiRC4clu1MsEGeirDD-fLdYHJD7xYOUvkEIiRT0qDiqIONcVouiX_rQhvUIggNnLnqjezDEcav7kEJnE_D5vrFgSDYf4NoRfOn8EMwm9E30oT8FP3X0um4t0P3g17YHJujhNKN6bdtWR6CHQZtNZ_vh68PintNtso_29bj4cHH-fvW6vLq5fLM6uyoNhVSUwlJUa8exEZhwzmrkpGO0YVTiBtZM4IZbQolBDkNaVbCq8q8xsaShlkBbHRfP57nbGH7sbBpU55OZ1ult2CXFBeMMC5JBMoMmhpSidWobfafjqBBUk2Y1OVSTQyWE-qtZsRx7up-_qzvbHEJ7r7n_bN_XyejWRd0bn_7NllxKinnm5Mz98q0d_-tttbxZIUJFzpZz1qfB_j5kdfyuGK84VZ-uL9X1x1u0fLeE6m3mH8-800Hpdcz7XNwKCSd71R-C761v</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Vickerman, K. (University of Glasgow (UK). Department of Zoology)</creator><creator>Tetley, L</creator><creator>Hendry, A.K</creator><creator>Turner, M.R</creator><general>Blackwell Publishing Ltd</general><general>Portland</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Biology of African trypanosomes in the tsetse fly [mitochondrion, variable antigen coat, flagellar attachment]</title><author>Vickerman, K. (University of Glasgow (UK). Department of Zoology) ; Tetley, L ; Hendry, A.K ; Turner, M.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5058-8e51baf72c824776b1f9f65d6592d0b682d7e454c1f2053303376824e4d5e40e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>ANIMAL DISEASES</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CICLO VITAL</topic><topic>CYCLE DE DEVELOPPEMENT</topic><topic>ENFERMEDADES DE LOS ANIMALES</topic><topic>flagellar attachment</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLOSSINIDAE</topic><topic>Host-Parasite Interactions</topic><topic>LIFE CYCLE</topic><topic>MALADIE DES ANIMAUX</topic><topic>MICROBIAL PROPERTIES</topic><topic>mitochondrion</topic><topic>PODER MICROBIANO</topic><topic>PROPRIETE DES MICROORGANISMES</topic><topic>Protozoa</topic><topic>TRYPANOSOMA</topic><topic>Trypanosoma - physiology</topic><topic>trypanosome</topic><topic>Tsetse Flies - parasitology</topic><topic>ULTRAESTRUCTURA</topic><topic>ULTRASTRUCTURE</topic><topic>variable antigen coat</topic><topic>VECTEUR</topic><topic>VECTORES</topic><topic>VECTORS</topic><topic>ZOONOSE</topic><topic>ZOONOSES</topic><topic>ZOONOSIS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vickerman, K. (University of Glasgow (UK). Department of Zoology)</creatorcontrib><creatorcontrib>Tetley, L</creatorcontrib><creatorcontrib>Hendry, A.K</creatorcontrib><creatorcontrib>Turner, M.R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of the cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vickerman, K. (University of Glasgow (UK). 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These include: a repressible single mitochondrion with a large mass of mitochondrial DNA, the kinetoplast; a special organelle, the glycosome, which houses the enzymes of the glycolytic chain; a surface coat of variable glycoprotein which enables the parasite to evade the mammalian host's immune response; and a unique flagellum‐to‐host attachment mechanism associated with novel cytoskeletal elements. Trypanosome development during the life cycle involves cyclical activation and repression of genes controlling these activities. Understanding the complexity of parasite development in the tsetse fly vector is especially challenging but may help to suggest new methods for the control of trypanosomiasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3067793</pmid><doi>10.1016/0248-4900(88)90070-6</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of the cell, 1988, Vol.64 (2), p.109-119 |
| issn | 0248-4900 1768-322X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | ANIMAL DISEASES Animals Biological and medical sciences CICLO VITAL CYCLE DE DEVELOPPEMENT ENFERMEDADES DE LOS ANIMALES flagellar attachment Fundamental and applied biological sciences. Psychology GLOSSINIDAE Host-Parasite Interactions LIFE CYCLE MALADIE DES ANIMAUX MICROBIAL PROPERTIES mitochondrion PODER MICROBIANO PROPRIETE DES MICROORGANISMES Protozoa TRYPANOSOMA Trypanosoma - physiology trypanosome Tsetse Flies - parasitology ULTRAESTRUCTURA ULTRASTRUCTURE variable antigen coat VECTEUR VECTORES VECTORS ZOONOSE ZOONOSES ZOONOSIS |
| title | Biology of African trypanosomes in the tsetse fly [mitochondrion, variable antigen coat, flagellar attachment] |
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