ATP-independent DNA topoisomerase II as potential drug target in trypanosomes
Two categories of trypanosomal type II topoisomerases have been isolated from trypanosomes: one is unique since it is able to realize DNA topoisomerization reactions in the absence of ATP, in contrast to the other enzyme and mammalian topoisomerase II. The biochemical properties of ATP‐independent t...
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| Veröffentlicht in: | Biology of the cell 1988, Vol.64 (2), p.145-156 |
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| container_title | Biology of the cell |
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| creator | Douc-Rasy, Sétha Riou, Jean-Franc¸ois Ahomadegbe, Jean-Charles Riou, Guy |
| description | Two categories of trypanosomal type II topoisomerases have been isolated from trypanosomes: one is unique since it is able to realize DNA topoisomerization reactions in the absence of ATP, in contrast to the other enzyme and mammalian topoisomerase II. The biochemical properties of ATP‐independent topoisomerase II from Trypanosoma cruzi are described in this report. The enzyme can decatenate trypanosome kinetoplast DNA networks, catenate supercoiled DNA molecules, unknot P4 phage DNA, and cleave double‐stranded DNA. The enzyme is inhibited by various classes of drugs and is more sensitive than mammalian topoisomerase II. Therefore, trypanosome ATP‐independent topoisomerase II provides a potential target for chemotherapy. |
| doi_str_mv | 10.1016/0248-4900(88)90074-3 |
| format | Article |
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The biochemical properties of ATP‐independent topoisomerase II from Trypanosoma cruzi are described in this report. The enzyme can decatenate trypanosome kinetoplast DNA networks, catenate supercoiled DNA molecules, unknot P4 phage DNA, and cleave double‐stranded DNA. The enzyme is inhibited by various classes of drugs and is more sensitive than mammalian topoisomerase II. Therefore, trypanosome ATP‐independent topoisomerase II provides a potential target for chemotherapy.</description><identifier>ISSN: 0248-4900</identifier><identifier>EISSN: 1768-322X</identifier><identifier>DOI: 10.1016/0248-4900(88)90074-3</identifier><identifier>PMID: 2852517</identifier><identifier>CODEN: BCELDF</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenosine Triphosphate ; Alkaloids - pharmacology ; Animals ; ATP-independent ; Biological and medical sciences ; DNA Topoisomerases, Type II - analysis ; DNA Topoisomerases, Type II - isolation & purification ; DNA, Viral - metabolism ; DNA, Viral - ultrastructure ; Drug Design ; Electrophoresis, Agar Gel ; Ellipticines - pharmacology ; Fundamental and applied biological sciences. Psychology ; inhibitory drugs ; Microscopy, Electron ; Protozoa ; Simian virus 40 - genetics ; topoisomerase II ; Topoisomerase II Inhibitors ; Trypanosoma cruzi - enzymology</subject><ispartof>Biology of the cell, 1988, Vol.64 (2), p.145-156</ispartof><rights>1988 Société Française des Microscopies and Société Biologie Cellulaire de France</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4202-1b9a0166ae3084eb0a5fc7ca54214a68c19929f6aa1427097ce413dd2dee459d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23909,23910,25118,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19799530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2852517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Douc-Rasy, Sétha</creatorcontrib><creatorcontrib>Riou, Jean-Franc¸ois</creatorcontrib><creatorcontrib>Ahomadegbe, Jean-Charles</creatorcontrib><creatorcontrib>Riou, Guy</creatorcontrib><title>ATP-independent DNA topoisomerase II as potential drug target in trypanosomes</title><title>Biology of the cell</title><addtitle>Biol Cell</addtitle><description>Two categories of trypanosomal type II topoisomerases have been isolated from trypanosomes: one is unique since it is able to realize DNA topoisomerization reactions in the absence of ATP, in contrast to the other enzyme and mammalian topoisomerase II. The biochemical properties of ATP‐independent topoisomerase II from Trypanosoma cruzi are described in this report. The enzyme can decatenate trypanosome kinetoplast DNA networks, catenate supercoiled DNA molecules, unknot P4 phage DNA, and cleave double‐stranded DNA. The enzyme is inhibited by various classes of drugs and is more sensitive than mammalian topoisomerase II. Therefore, trypanosome ATP‐independent topoisomerase II provides a potential target for chemotherapy.</description><subject>Adenosine Triphosphate</subject><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>ATP-independent</subject><subject>Biological and medical sciences</subject><subject>DNA Topoisomerases, Type II - analysis</subject><subject>DNA Topoisomerases, Type II - isolation & purification</subject><subject>DNA, Viral - metabolism</subject><subject>DNA, Viral - ultrastructure</subject><subject>Drug Design</subject><subject>Electrophoresis, Agar Gel</subject><subject>Ellipticines - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>inhibitory drugs</subject><subject>Microscopy, Electron</subject><subject>Protozoa</subject><subject>Simian virus 40 - genetics</subject><subject>topoisomerase II</subject><subject>Topoisomerase II Inhibitors</subject><subject>Trypanosoma cruzi - enzymology</subject><issn>0248-4900</issn><issn>1768-322X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1vEzEQxS1E1YbCfwCSLyB6WOqvXdvHNNAQqR9IFMHNmnhnK5fN7tbeiOa_r0OicOUyc3i_90bzCHnL2SfOeHXOhDKFsox9NOYsL60K-YJMuK5MIYX49ZJMDsgJeZXSA2NMWVMek2NhSlFyPSHX07tvRehqHDCPbqSfb6Z07Ic-pH6FERLSxYJCokM_ZjlAS-u4vqcjxHscaejoGDcDdP0WT6_JUQNtwjf7fUp-XH65m30trm7ni9n0qvBKMFHwpYX8QQUomVG4ZFA2XnsoleAKKuO5tcI2FQBXQjOrPSou61rUiKq0tTwlH3a5Q-wf15hGtwrJY9tCh_06OW0qrYzmGVQ70Mc-pYiNG2JYQdw4zty2RbetyG0rcsa4vy06mW3v9vnr5Qrrg2lfW9bf73VIHtomQudD-pdttbWlZJmzO-5PaHHzX7fdxe2Mq0pkb7HzhjTi08EL8bertNSl-3kzdxdiLi-1-u60fAZqH5j2</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Douc-Rasy, Sétha</creator><creator>Riou, Jean-Franc¸ois</creator><creator>Ahomadegbe, Jean-Charles</creator><creator>Riou, Guy</creator><general>Blackwell Publishing Ltd</general><general>Portland</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>ATP-independent DNA topoisomerase II as potential drug target in trypanosomes</title><author>Douc-Rasy, Sétha ; Riou, Jean-Franc¸ois ; Ahomadegbe, Jean-Charles ; Riou, Guy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4202-1b9a0166ae3084eb0a5fc7ca54214a68c19929f6aa1427097ce413dd2dee459d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenosine Triphosphate</topic><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>ATP-independent</topic><topic>Biological and medical sciences</topic><topic>DNA Topoisomerases, Type II - analysis</topic><topic>DNA Topoisomerases, Type II - isolation & purification</topic><topic>DNA, Viral - metabolism</topic><topic>DNA, Viral - ultrastructure</topic><topic>Drug Design</topic><topic>Electrophoresis, Agar Gel</topic><topic>Ellipticines - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>inhibitory drugs</topic><topic>Microscopy, Electron</topic><topic>Protozoa</topic><topic>Simian virus 40 - genetics</topic><topic>topoisomerase II</topic><topic>Topoisomerase II Inhibitors</topic><topic>Trypanosoma cruzi - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Douc-Rasy, Sétha</creatorcontrib><creatorcontrib>Riou, Jean-Franc¸ois</creatorcontrib><creatorcontrib>Ahomadegbe, Jean-Charles</creatorcontrib><creatorcontrib>Riou, Guy</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of the cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Douc-Rasy, Sétha</au><au>Riou, Jean-Franc¸ois</au><au>Ahomadegbe, Jean-Charles</au><au>Riou, Guy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ATP-independent DNA topoisomerase II as potential drug target in trypanosomes</atitle><jtitle>Biology of the cell</jtitle><addtitle>Biol Cell</addtitle><date>1988</date><risdate>1988</risdate><volume>64</volume><issue>2</issue><spage>145</spage><epage>156</epage><pages>145-156</pages><issn>0248-4900</issn><eissn>1768-322X</eissn><coden>BCELDF</coden><abstract>Two categories of trypanosomal type II topoisomerases have been isolated from trypanosomes: one is unique since it is able to realize DNA topoisomerization reactions in the absence of ATP, in contrast to the other enzyme and mammalian topoisomerase II. The biochemical properties of ATP‐independent topoisomerase II from Trypanosoma cruzi are described in this report. The enzyme can decatenate trypanosome kinetoplast DNA networks, catenate supercoiled DNA molecules, unknot P4 phage DNA, and cleave double‐stranded DNA. The enzyme is inhibited by various classes of drugs and is more sensitive than mammalian topoisomerase II. Therefore, trypanosome ATP‐independent topoisomerase II provides a potential target for chemotherapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2852517</pmid><doi>10.1016/0248-4900(88)90074-3</doi><tpages>12</tpages></addata></record> |
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| ispartof | Biology of the cell, 1988, Vol.64 (2), p.145-156 |
| issn | 0248-4900 1768-322X |
| language | eng |
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| subjects | Adenosine Triphosphate Alkaloids - pharmacology Animals ATP-independent Biological and medical sciences DNA Topoisomerases, Type II - analysis DNA Topoisomerases, Type II - isolation & purification DNA, Viral - metabolism DNA, Viral - ultrastructure Drug Design Electrophoresis, Agar Gel Ellipticines - pharmacology Fundamental and applied biological sciences. Psychology inhibitory drugs Microscopy, Electron Protozoa Simian virus 40 - genetics topoisomerase II Topoisomerase II Inhibitors Trypanosoma cruzi - enzymology |
| title | ATP-independent DNA topoisomerase II as potential drug target in trypanosomes |
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