Nonsteroidal Antiinflammatory Drug Modulation of Behavioral Responses to Intrathecal N‐Methyl‐D‐Aspartate, but Not to Substance P and Amino‐Methyl‐Isoxazole‐Propionic Acid in the Rat

Antinociception by nonsteroidal antiinflammatory drugs, notably diclofenac and S(+)‐ ibuprofen, has traditionally been attributed to peripheral tissue cyclooxygenase inhibition. This study investigates the potential role of the nitric oxide system for the central antinociceptive effects of diclofena...

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Veröffentlicht in:	Journal of clinical pharmacology 1996-12, Vol.36 (12), p.20S-26S
Hauptverfasser:	Björkman, Roland, Hallman, Katarina M., Hedner, Jan, Hedner, Thomas, Henning, Matts
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Analgesics Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Behavior, Animal - drug effects Biological and medical sciences Diclofenac - pharmacology Ibuprofen - pharmacology Male Medical sciences N-Methylaspartate - administration & dosage N-Methylaspartate - pharmacology Neuropharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Stereoisomerism Substance P - administration & dosage Substance P - pharmacology
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