Tolerance to nicotine's effects on striatal dopamine metabolism in nicotine-withdrawn mice

After 7-week chronic administration of nicotine to mice in their drinking water, nicotine was withdrawn for 24 h. Acute nicotine challenge (1 mg/kg s.c., 60 min) elevated the striatal concentrations of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and decreased the concentration of...

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Veröffentlicht in:	European journal of pharmacology 1996-12, Vol.318 (1), p.17-22
Hauptverfasser:	Pietilä, Kirsi, Salminen, Outi, Leikola-Pelho, Taru, Ahtee, Liisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Temperature - drug effects Brain Chemistry - drug effects Corpus Striatum - chemistry Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Dopamine receptor Drug Tolerance Male Medical sciences Mice Mice, Inbred Strains mouse Nicotine Nicotine - pharmacology Receptors, Dopamine - drug effects Receptors, Dopamine D1 - drug effects Receptors, Dopamine D2 - drug effects Striatum Tobacco, tobacco smoking Tolerance Toxicology
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