Pituitary Adenylate‐Cyclase‐Activating Polypeptide Stimulates Proto‐oncogene Expression and Activates the AP‐1 (c‐Fos/c‐Jun) Transcription Factor in AR4‐2J Pancreatic Carcinoma Cells

Pituitary adenylate‐cyclase‐activating polypeptide (PACAP) has been shown to possess mitogenic activity in various tumor cells. The present study was designed to investigate signal transduction mechanisms and expression of the proto‐oncogenes c‐fos and c‐jun linked to the mitogenic effect of PACAP i...

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Veröffentlicht in:	European journal of biochemistry 1996-12, Vol.242 (3), p.467-476
Hauptverfasser:	Schäfer, Heiner, Zheng, Jie, Gundlach, Friederike, Günther, Rainer, Siegel, Erhard G., Fölsch, Ulrich R., Schmidt, Wolfgang E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Cycle Cyclic AMP - metabolism Cytosol - metabolism Enzyme Inhibitors - pharmacology gastrointestinal hormone gene expression Gene Expression Regulation Genes, fos Genes, jun Inositol 1,4,5-Trisphosphate - metabolism Mitogens Neuropeptides - physiology pancreatic carcinoma Pituitary Adenylate Cyclase-Activating Polypeptide Protein Kinase C - antagonists & inhibitors Protein-Tyrosine Kinases - antagonists & inhibitors proto‐oncogene Rats RNA, Messenger - metabolism Signal Transduction - drug effects Sulfonamides - pharmacology transcription factor Transcription Factor AP-1 - metabolism
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