Dysfunctional muscarinic M2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction

We studied the function of autoinhibitory muscarinic M2 receptors on vagal nerve endings in the airways of conscious, unrestrained, ovalbumin-sensitized guinea pigs after the early and late allergic reaction. For this purpose, the effects of the selective muscarinic M2 receptor antagonist gallamine...

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Veröffentlicht in:	European journal of pharmacology 1996-12, Vol.318 (1), p.131-139
Hauptverfasser:	TEN BERGE, R. E. J, KRIKKE, M, TEISMAN, A. C. H, ROFFEL, A. F, ZAAGSMA, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - immunology Animals Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - physiopathology Bronchoconstriction - drug effects Bronchoconstriction - physiology Electric Stimulation Experimental and animal immunopathology. Animal models Female Gallamine Triethiodide - pharmacology Guinea Pigs Histamine - pharmacology Hypersensitivity - immunology Hypersensitivity - physiopathology Immunopathology Male Medical sciences Ovalbumin - immunology Receptor, Muscarinic M2 Receptors, Muscarinic - physiology Vagus Nerve - physiology
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