Effects of pinacidil on guinea-pig airway smooth muscle contracted by asthma mediators

Pinacidil is a new antihypertensive, direct vasodilator drug which has been classified as a K + channel opener. The present study demonstrated a concentration-dependent relaxant activity of pinacidil in guinea-pig tracheal preparations. The potency and efficacy of pinacidil depended on the agent use...

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Veröffentlicht in:	European journal of pharmacology 1988-11, Vol.157 (2), p.221-226
Hauptverfasser:	Nielsen-Kudsk, Jens Erik, Mellemkjær, Søren, Siggaard, Charlotte, Nielsen, Claus Brøckner
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Antihypertensive Agents - pharmacology Asthma - drug therapy Biological and medical sciences Cardiovascular system Female Guanidines - pharmacology Guinea Pigs K + channel opening Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Pharmacology. Drug treatments Pinacidil Potassium - pharmacology smooth muscle Smooth muscle (airway) trachea Trachea (guinea-pig) Trachea - drug effects
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