The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation
1. 1. Sibutramine hydrochloride (BTS 54 524) has been evaluated in a range of behavioural and biochemical models predictive of potential antidepressant activity. 2. 2. BTS 54 524 exhibited potent activity in acute behavioural tests for detecting potential antldepressants. 3. 3. BTS 54 524 rapidly an...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1988, Vol.12 (5), p.575-584 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Buckett, W.Roger Thomas, Peter C. Luscombe, Graham P. |
| description | 1.
1. Sibutramine hydrochloride (BTS 54 524) has been evaluated in a range of behavioural and biochemical models predictive of potential antidepressant activity.
2.
2. BTS 54 524 exhibited potent activity in acute behavioural tests for detecting potential antldepressants.
3.
3. BTS 54 524 rapidly and potently down-regulated rat cortical β-adrenoceptors, being effective after only three days of oral administration.
4.
4. BTS 54 524 showed very little activity in a range of experiments predictive of side-effect potential.
5.
5. BTS 54 524 possesses a pharmacological profile which suggests that it may be a potent antidepressant with a rapid onset of action, and with a low potential for causing side-effects. |
| doi_str_mv | 10.1016/0278-5846(88)90003-6 |
| format | Article |
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1. Sibutramine hydrochloride (BTS 54 524) has been evaluated in a range of behavioural and biochemical models predictive of potential antidepressant activity.
2.
2. BTS 54 524 exhibited potent activity in acute behavioural tests for detecting potential antldepressants.
3.
3. BTS 54 524 rapidly and potently down-regulated rat cortical β-adrenoceptors, being effective after only three days of oral administration.
4.
4. BTS 54 524 showed very little activity in a range of experiments predictive of side-effect potential.
5.
5. BTS 54 524 possesses a pharmacological profile which suggests that it may be a potent antidepressant with a rapid onset of action, and with a low potential for causing side-effects.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/0278-5846(88)90003-6</identifier><identifier>PMID: 2851857</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adenylyl Cyclases - metabolism ; Animals ; Antidepressant ; Antidepressive Agents, Tricyclic - pharmacology ; Biological and medical sciences ; Blepharoptosis - drug therapy ; Body Temperature Regulation - drug effects ; BTS 54 524 ; Cerebral Cortex - metabolism ; Cyclobutanes - pharmacology ; Discrimination (Psychology) - drug effects ; Female ; Helplessness, Learned - physiopathology ; In Vitro Techniques ; Male ; Medical sciences ; Mice ; Monoamine Oxidase Inhibitors - pharmacology ; Motor Activity - drug effects ; Neuropharmacology ; noradrenergic down-regulation ; Norepinephrine - metabolism ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, beta - drug effects ; Receptors, Adrenergic, beta - metabolism ; Reserpine - pharmacology ; sibutramine</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 1988, Vol.12 (5), p.575-584</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-4ef49837f7d91734b51c9e42cf201b51919ecf333f1b34b4ec194e5c8cdfa9f3</citedby><cites>FETCH-LOGICAL-c483t-4ef49837f7d91734b51c9e42cf201b51919ecf333f1b34b4ec194e5c8cdfa9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0278-5846(88)90003-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6630632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2851857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckett, W.Roger</creatorcontrib><creatorcontrib>Thomas, Peter C.</creatorcontrib><creatorcontrib>Luscombe, Graham P.</creatorcontrib><title>The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>1.
1. Sibutramine hydrochloride (BTS 54 524) has been evaluated in a range of behavioural and biochemical models predictive of potential antidepressant activity.
2.
2. BTS 54 524 exhibited potent activity in acute behavioural tests for detecting potential antldepressants.
3.
3. BTS 54 524 rapidly and potently down-regulated rat cortical β-adrenoceptors, being effective after only three days of oral administration.
4.
4. BTS 54 524 showed very little activity in a range of experiments predictive of side-effect potential.
5.
5. BTS 54 524 possesses a pharmacological profile which suggests that it may be a potent antidepressant with a rapid onset of action, and with a low potential for causing side-effects.</description><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Antidepressant</subject><subject>Antidepressive Agents, Tricyclic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blepharoptosis - drug therapy</subject><subject>Body Temperature Regulation - drug effects</subject><subject>BTS 54 524</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cyclobutanes - pharmacology</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Female</subject><subject>Helplessness, Learned - physiopathology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Monoamine Oxidase Inhibitors - pharmacology</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>noradrenergic down-regulation</subject><subject>Norepinephrine - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Adrenergic, beta - drug effects</subject><subject>Receptors, Adrenergic, beta - metabolism</subject><subject>Reserpine - pharmacology</subject><subject>sibutramine</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGLFDEQhYO4rOPqP1DIQWQXbE06SXf6IqyLusKCB-ceMkllOtKdtEm3w1z95ZtxhjnqKZV6XxXFewi9ouQ9JbT5QOpWVkLy5lrKm44QwqrmCVpRWdq8ps1TtDojz9DznH8WhjLCLtFlLQWVol2hP-se8NTrNGoTh7jd4-hw9ptlTnr0AXC_tymafojJW8DXn9Y_sOBY1PzmHdY4wA7rMBdpSpBzKfGu96bHPtjFQMZJT97iEJO2CQKkrTfYxl2oEmyXQc8-hhfowukhw8vTe4XWXz6v7-6rh-9fv93dPlSGSzZXHBzvJGtdazvaMr4R1HTAa-NqQsunox0YxxhzdFNUDoZ2HISRxjrdOXaF3h7XTin-WiDPavTZwDDoAHHJqpWNkITy_4JUEFFLSQrIj6BJMecETk3JjzrtFSXqEJE6-K8O_isp1d-IVFPGXp_2L5sR7HnolEnR35x0nY0eXNLB-HzGmoaRhtUF-3jEoHj220NS2XgIBqxPYGZlo__3HY-mX63J</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Buckett, W.Roger</creator><creator>Thomas, Peter C.</creator><creator>Luscombe, Graham P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation</title><author>Buckett, W.Roger ; Thomas, Peter C. ; Luscombe, Graham P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-4ef49837f7d91734b51c9e42cf201b51919ecf333f1b34b4ec194e5c8cdfa9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Antidepressant</topic><topic>Antidepressive Agents, Tricyclic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blepharoptosis - drug therapy</topic><topic>Body Temperature Regulation - drug effects</topic><topic>BTS 54 524</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cyclobutanes - pharmacology</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Female</topic><topic>Helplessness, Learned - physiopathology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Monoamine Oxidase Inhibitors - pharmacology</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>noradrenergic down-regulation</topic><topic>Norepinephrine - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Adrenergic, beta - drug effects</topic><topic>Receptors, Adrenergic, beta - metabolism</topic><topic>Reserpine - pharmacology</topic><topic>sibutramine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckett, W.Roger</creatorcontrib><creatorcontrib>Thomas, Peter C.</creatorcontrib><creatorcontrib>Luscombe, Graham P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buckett, W.Roger</au><au>Thomas, Peter C.</au><au>Luscombe, Graham P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>1988</date><risdate>1988</risdate><volume>12</volume><issue>5</issue><spage>575</spage><epage>584</epage><pages>575-584</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>1.
1. Sibutramine hydrochloride (BTS 54 524) has been evaluated in a range of behavioural and biochemical models predictive of potential antidepressant activity.
2.
2. BTS 54 524 exhibited potent activity in acute behavioural tests for detecting potential antldepressants.
3.
3. BTS 54 524 rapidly and potently down-regulated rat cortical β-adrenoceptors, being effective after only three days of oral administration.
4.
4. BTS 54 524 showed very little activity in a range of experiments predictive of side-effect potential.
5.
5. BTS 54 524 possesses a pharmacological profile which suggests that it may be a potent antidepressant with a rapid onset of action, and with a low potential for causing side-effects.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2851857</pmid><doi>10.1016/0278-5846(88)90003-6</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0278-5846 |
| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 1988, Vol.12 (5), p.575-584 |
| issn | 0278-5846 1878-4216 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenylyl Cyclases - metabolism Animals Antidepressant Antidepressive Agents, Tricyclic - pharmacology Biological and medical sciences Blepharoptosis - drug therapy Body Temperature Regulation - drug effects BTS 54 524 Cerebral Cortex - metabolism Cyclobutanes - pharmacology Discrimination (Psychology) - drug effects Female Helplessness, Learned - physiopathology In Vitro Techniques Male Medical sciences Mice Monoamine Oxidase Inhibitors - pharmacology Motor Activity - drug effects Neuropharmacology noradrenergic down-regulation Norepinephrine - metabolism Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Reserpine - pharmacology sibutramine |
| title | The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation |
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