Sequence of mdr3 cDNA encoding a human P-glycoprotein

We have determined the sequence of the human mdr3 gene using cDNA derived from liver RNA. The mdr3 gene codes for a member of a family of membrane proteins, the P-glycoproteins, overproduced in many multi-drug-resistant (MDR) cell lines. Like its relatives, the protein encoded by mdr3 has a deduced...

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Veröffentlicht in:	Gene 1988-11, Vol.71 (2), p.401-411
Hauptverfasser:	van der Bliek, A.M., Kooiman, P.M., Schneider, C., Borst, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence ATP Binding Cassette Transporter, Subfamily B, Member 1 Bacteriophage lambda - genetics Base Sequence Biological and medical sciences DNA - biosynthesis DNA - genetics DNA - isolation & purification Drug Resistance - genetics efflux pump Fundamental and applied biological sciences. Psychology Genes. Genome Humans hydrophobic segment liver RNA Membrane Glycoproteins - genetics membrane transport Molecular and cellular biology Molecular genetics Molecular Sequence Data multi-drug resistance Multigene Family nucleotide-binding domain, rootless tree Recombinant DNA Transfection
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