Autoradiographic distribution of [3H]-(S)-zacopride-labelled 5-HT3 receptors in human brain

Autoradiographic binding studies using the 5-HT3 (5-hydroxytryptamine3) receptor radioligand, [3H]-(S)-zacopride (0.5 nM), identified a heterogeneous distribution of specific binding sites (defined by granisetron, 1 microM) throughout the human brain. Highest radiolabelled 5-HT3 receptor densities w...

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Veröffentlicht in:	Journal of the neurological sciences 1996-12, Vol.144 (1-2), p.119-127
Hauptverfasser:	PARKER, R. M. C, BARNES, J. M, GE, J, BARBER, P. C, BARNES, N. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Autoradiography Benzamides - metabolism Biological and medical sciences Brain Stem - metabolism Bridged Bicyclo Compounds, Heterocyclic - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Female Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Prosencephalon - metabolism Radioligand Assay Receptors, Serotonin - metabolism Serotonin Antagonists - metabolism Tritium Vertebrates: nervous system and sense organs
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