Sex-related differences in the relationships between self-rated depression and biological markers
Gender-related differences in self-reported depression, in biological factors putatively related to depression and in the associations between severity of illness and biological factors were investigated. To this end the Zung Self-Rating Depression Scale (SDS), the ratio L-tryptophan/valine + leucin...
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| Veröffentlicht in: | Journal of affective disorders 1988-09, Vol.15 (2), p.119-125 |
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| creator | Maes, M. De Ruyter, M. Claes, R. Suy, E. |
| description | Gender-related differences in self-reported depression, in biological factors putatively related to depression and in the associations between severity of illness and biological factors were investigated. To this end the Zung Self-Rating Depression Scale (SDS), the ratio
L-tryptophan/valine + leucine (
L-TRP/CAA) and basal cortisol in serum at 8 a.m. were determined in 51 depressed inpatients undergoing a dexamethasone suppression test (DST). In the total study group no significant relationships were established between severity of illness and either of the biological markers. In women, SDS correlated significantly (
P < 0.01) negatively with the ratio
L-TRP/CAA and positively with post-dexamethasone cortisol (
P < 0.01). In men these relationships tended to be inverted. The differences in the two sexes between these correlation coefficients were significant (
P < 0.01). These gender-related differences in the relationships between self-reported depression and the biological variables could be explained by differential psychoneuroendocrine and psychobiochemical responses. Future work on the severity of illnesses in terms of biological factors must take into account these differential responses between depressed males and females. |
| doi_str_mv | 10.1016/0165-0327(88)90079-1 |
| format | Article |
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L-tryptophan/valine + leucine (
L-TRP/CAA) and basal cortisol in serum at 8 a.m. were determined in 51 depressed inpatients undergoing a dexamethasone suppression test (DST). In the total study group no significant relationships were established between severity of illness and either of the biological markers. In women, SDS correlated significantly (
P < 0.01) negatively with the ratio
L-TRP/CAA and positively with post-dexamethasone cortisol (
P < 0.01). In men these relationships tended to be inverted. The differences in the two sexes between these correlation coefficients were significant (
P < 0.01). These gender-related differences in the relationships between self-reported depression and the biological variables could be explained by differential psychoneuroendocrine and psychobiochemical responses. Future work on the severity of illnesses in terms of biological factors must take into account these differential responses between depressed males and females.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/0165-0327(88)90079-1</identifier><identifier>PMID: 2975681</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Amino Acids - blood ; Biological and medical sciences ; Biological markers ; Depression ; Depressive Disorder - blood ; Depressive Disorder - diagnosis ; Depressive Disorder - psychology ; Dexamethasone ; Female ; Humans ; Hydrocortisone - blood ; Leucine - blood ; Male ; Medical sciences ; Miscellaneous ; Psychological Tests ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sex Factors ; Sex-linked differences ; Techniques and methods ; Tryptophan - blood ; Valine - blood</subject><ispartof>Journal of affective disorders, 1988-09, Vol.15 (2), p.119-125</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1e49c0c03f6979e8850bb2c804d4848f0e0b12dfc7105482e68546d95a4e82c43</citedby><cites>FETCH-LOGICAL-c386t-1e49c0c03f6979e8850bb2c804d4848f0e0b12dfc7105482e68546d95a4e82c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-0327(88)90079-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6606125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2975681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maes, M.</creatorcontrib><creatorcontrib>De Ruyter, M.</creatorcontrib><creatorcontrib>Claes, R.</creatorcontrib><creatorcontrib>Suy, E.</creatorcontrib><title>Sex-related differences in the relationships between self-rated depression and biological markers</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Gender-related differences in self-reported depression, in biological factors putatively related to depression and in the associations between severity of illness and biological factors were investigated. To this end the Zung Self-Rating Depression Scale (SDS), the ratio
L-tryptophan/valine + leucine (
L-TRP/CAA) and basal cortisol in serum at 8 a.m. were determined in 51 depressed inpatients undergoing a dexamethasone suppression test (DST). In the total study group no significant relationships were established between severity of illness and either of the biological markers. In women, SDS correlated significantly (
P < 0.01) negatively with the ratio
L-TRP/CAA and positively with post-dexamethasone cortisol (
P < 0.01). In men these relationships tended to be inverted. The differences in the two sexes between these correlation coefficients were significant (
P < 0.01). These gender-related differences in the relationships between self-reported depression and the biological variables could be explained by differential psychoneuroendocrine and psychobiochemical responses. Future work on the severity of illnesses in terms of biological factors must take into account these differential responses between depressed males and females.</description><subject>Adult</subject><subject>Amino Acids - blood</subject><subject>Biological and medical sciences</subject><subject>Biological markers</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - psychology</subject><subject>Dexamethasone</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Leucine - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Psychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sex Factors</subject><subject>Sex-linked differences</subject><subject>Techniques and methods</subject><subject>Tryptophan - blood</subject><subject>Valine - blood</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1UtGwL_wAkHypUDoFxYjvOpVJVtYC0EgfgbDn2uHWbTbaeLB__Hm93tUcOlg_v845mHsbeCvgoQOhP5akKmrq9MOZDB9B2lXjBlkK1TVUr0Z6w5RF5xU6JHgBAdy0s2KLuWqWNWDL3Hf9UGQc3Y-AhxYgZR4_E08jne-TPUZpGuk8b4j3OvxFHTjjEKu87uMlIVBDuxsD7NA3TXfJu4GuXHzHTa_YyuoHwzeE_Yz9vb35cf6lW3z5_vb5aVb4xeq4Eys6DhyaWFTs0RkHf196ADNJIEwGhF3WIvhWgpKlRGyV16JSTaGovmzP2fj93k6enLdJs14k8DoMbcdqSbY1WslO6gHIP-jwRZYx2k1NZ9q8VYHdm7U6b3Wmzxthns1aU2rvD_G2_xnAsHVSW_PyQOyrnx-xGn-iIaQ1a1Kpgl3sMi4tfCbMln3bKQ8roZxum9P89_gHdjpT5</recordid><startdate>19880901</startdate><enddate>19880901</enddate><creator>Maes, M.</creator><creator>De Ruyter, M.</creator><creator>Claes, R.</creator><creator>Suy, E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880901</creationdate><title>Sex-related differences in the relationships between self-rated depression and biological markers</title><author>Maes, M. ; De Ruyter, M. ; Claes, R. ; Suy, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1e49c0c03f6979e8850bb2c804d4848f0e0b12dfc7105482e68546d95a4e82c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Amino Acids - blood</topic><topic>Biological and medical sciences</topic><topic>Biological markers</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - psychology</topic><topic>Dexamethasone</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Leucine - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Psychological Tests</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sex Factors</topic><topic>Sex-linked differences</topic><topic>Techniques and methods</topic><topic>Tryptophan - blood</topic><topic>Valine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maes, M.</creatorcontrib><creatorcontrib>De Ruyter, M.</creatorcontrib><creatorcontrib>Claes, R.</creatorcontrib><creatorcontrib>Suy, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maes, M.</au><au>De Ruyter, M.</au><au>Claes, R.</au><au>Suy, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-related differences in the relationships between self-rated depression and biological markers</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1988-09-01</date><risdate>1988</risdate><volume>15</volume><issue>2</issue><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Gender-related differences in self-reported depression, in biological factors putatively related to depression and in the associations between severity of illness and biological factors were investigated. To this end the Zung Self-Rating Depression Scale (SDS), the ratio
L-tryptophan/valine + leucine (
L-TRP/CAA) and basal cortisol in serum at 8 a.m. were determined in 51 depressed inpatients undergoing a dexamethasone suppression test (DST). In the total study group no significant relationships were established between severity of illness and either of the biological markers. In women, SDS correlated significantly (
P < 0.01) negatively with the ratio
L-TRP/CAA and positively with post-dexamethasone cortisol (
P < 0.01). In men these relationships tended to be inverted. The differences in the two sexes between these correlation coefficients were significant (
P < 0.01). These gender-related differences in the relationships between self-reported depression and the biological variables could be explained by differential psychoneuroendocrine and psychobiochemical responses. Future work on the severity of illnesses in terms of biological factors must take into account these differential responses between depressed males and females.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2975681</pmid><doi>10.1016/0165-0327(88)90079-1</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of affective disorders, 1988-09, Vol.15 (2), p.119-125 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Amino Acids - blood Biological and medical sciences Biological markers Depression Depressive Disorder - blood Depressive Disorder - diagnosis Depressive Disorder - psychology Dexamethasone Female Humans Hydrocortisone - blood Leucine - blood Male Medical sciences Miscellaneous Psychological Tests Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sex Factors Sex-linked differences Techniques and methods Tryptophan - blood Valine - blood |
| title | Sex-related differences in the relationships between self-rated depression and biological markers |
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