Interleukin‐4 stimulates rheumatoid synovial fibroblasts to express matrix metalloproteinase‐1 (tissue collagenase) and histamine H1 receptor mRNA

In the present study, we investigated the effect of interleukin‐4 (IL‐4) on metalloproteinase 1 (MMP‐1/tissue collagenase) production in human rheumatoid synovial fibroblasts. Northern blot analysis revealed that addition of IL‐4 with or without histamine stimulated the cells to increase the amount...

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Veröffentlicht in:	Biochemistry and molecular biology international 1996-12, Vol.40 (6), p.1253-1260
Hauptverfasser:	Zenmyo, Michihisa, Hiraoka, Koji, Sasaguri, Takakazu, Komiya, Setsuro, Inoue, Akio, Morimatsu, Minoru, Sasaguri, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - metabolism Blotting, Northern Blotting, Western Cells, Cultured Collagenases - biosynthesis Collagenases - genetics Enzyme Precursors - biosynthesis Enzyme Precursors - genetics Fibroblasts - metabolism histamine H1 receptor Humans Interleukin-4 - pharmacology interleukin‐4 Matrix Metalloproteinase 1 Receptors, Histamine H1 - biosynthesis Receptors, Histamine H1 - genetics Rheumatoid arthritis RNA, Messenger - genetics RNA, Messenger - metabolism synovial fibroblasts Synovial Membrane - metabolism
Online-Zugang:	Volltext
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