Considerations in use of microspheres for myocardial blood-flow measurements in long-term experiments on rats

The loss of 15-μm radioactive microspheres from rat myocardium was determined in long-term experiments. Heterotopic heart transplantation was used for the evaluation of microsphere losses. Microspheres were injected into the left ventricle of a donor rat, and the number of microspheres entrapped in...

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Veröffentlicht in:	J. Pharmacol. Methods; (United States) 1988-09, Vol.20 (2), p.143-149
Hauptverfasser:	Medvedev, Oleg S., Martynova, Elena R., Akchurin, Renat S., Khalatov, Vadim Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	550901 - Pathology- Tracer Techniques ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BLOOD FLOW BODY CARDIOVASCULAR SYSTEM Conscious rat Coronary Circulation HEART Heart Transplantation Heterotopic heart transplantation Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) ISOTOPE APPLICATIONS ISOTOPES Male MAMMALS Medical sciences MICROSPHERES MUSCLES Myocardial blood flow MYOCARDIUM ORGANS Radioactive microsphere technique Radioisotopes RATS Rats, Inbred Strains RODENTS Scandium SCANDIUM ISOTOPES TRACER TECHNIQUES TRANSPLANTS VERTEBRATES
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