A linkage group of five DNA markers on human chromosome 10
Five chromosome 10 DNA markers ( D10S1, D10S3, D10S4, D10S5, and RBP3) were typed in five large pedigrees with multiple endocrine neoplasia type 2A (MEN-2A) and in five non-MEN-2A pedigrees. Linkage analyses showed that these loci and the locus for MEN-2A ( MEN2A) are in one linkage group spanning a...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1988-07, Vol.3 (1), p.72-77 |
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| creator | Farrer, L.A. Castiglione, C.M. Kidd, J.R. Myers, S. Carson, N. Simpson, N.E. Kidd, K.K. |
| description | Five chromosome 10 DNA markers (
D10S1,
D10S3,
D10S4,
D10S5, and
RBP3) were typed in five large pedigrees with multiple endocrine neoplasia type 2A (MEN-2A) and in five non-MEN-2A pedigrees. Linkage analyses showed that these loci and the locus for MEN-2A (
MEN2A) are in one linkage group spanning at least 70 cM. The order of the marker loci is
RBP3-D10S5-D10S3-D10S1-D10S4, with interlocus recombination frequencies of 7, 13–19, 19, and 19%, respectively, all on the same side of
MEN2A. Analyses of sex-specific recombination frequencies indicated no significant differences between males and females for any of the map intervals studied. Previous localization of
D10S5 and
RBP3 to the proximal region of the long arm and the pericentric region, respectively, comparison of results with other studies, and our preliminary results with other chromosome 10 markers suggest that the
D10S4 end of the map extends into the long arm. Our linkage map has been constructed using only two-and three-locus analyses. It will be possible to combine our results with those of other groups to construct a more detailed and accurate genetic map of chromosome 10. |
| doi_str_mv | 10.1016/0888-7543(88)90162-0 |
| format | Article |
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D10S1,
D10S3,
D10S4,
D10S5, and
RBP3) were typed in five large pedigrees with multiple endocrine neoplasia type 2A (MEN-2A) and in five non-MEN-2A pedigrees. Linkage analyses showed that these loci and the locus for MEN-2A (
MEN2A) are in one linkage group spanning at least 70 cM. The order of the marker loci is
RBP3-D10S5-D10S3-D10S1-D10S4, with interlocus recombination frequencies of 7, 13–19, 19, and 19%, respectively, all on the same side of
MEN2A. Analyses of sex-specific recombination frequencies indicated no significant differences between males and females for any of the map intervals studied. Previous localization of
D10S5 and
RBP3 to the proximal region of the long arm and the pericentric region, respectively, comparison of results with other studies, and our preliminary results with other chromosome 10 markers suggest that the
D10S4 end of the map extends into the long arm. Our linkage map has been constructed using only two-and three-locus analyses. It will be possible to combine our results with those of other groups to construct a more detailed and accurate genetic map of chromosome 10.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/0888-7543(88)90162-0</identifier><identifier>PMID: 2906045</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Chromosomes, Human, Pair 10 ; DNA Restriction Enzymes ; Female ; Gene Frequency ; Genetic Linkage ; Genetic Markers - analysis ; Haplotypes ; Humans ; Male ; Multiple Endocrine Neoplasia - genetics ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Sex Factors</subject><ispartof>Genomics (San Diego, Calif.), 1988-07, Vol.3 (1), p.72-77</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-167f68c506c909f79e9af350a7c9843f23b3b17f9ffa16396122dcbbc1d57ba3</citedby><cites>FETCH-LOGICAL-c272t-167f68c506c909f79e9af350a7c9843f23b3b17f9ffa16396122dcbbc1d57ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0888-7543(88)90162-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2906045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farrer, L.A.</creatorcontrib><creatorcontrib>Castiglione, C.M.</creatorcontrib><creatorcontrib>Kidd, J.R.</creatorcontrib><creatorcontrib>Myers, S.</creatorcontrib><creatorcontrib>Carson, N.</creatorcontrib><creatorcontrib>Simpson, N.E.</creatorcontrib><creatorcontrib>Kidd, K.K.</creatorcontrib><title>A linkage group of five DNA markers on human chromosome 10</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>Five chromosome 10 DNA markers (
D10S1,
D10S3,
D10S4,
D10S5, and
RBP3) were typed in five large pedigrees with multiple endocrine neoplasia type 2A (MEN-2A) and in five non-MEN-2A pedigrees. Linkage analyses showed that these loci and the locus for MEN-2A (
MEN2A) are in one linkage group spanning at least 70 cM. The order of the marker loci is
RBP3-D10S5-D10S3-D10S1-D10S4, with interlocus recombination frequencies of 7, 13–19, 19, and 19%, respectively, all on the same side of
MEN2A. Analyses of sex-specific recombination frequencies indicated no significant differences between males and females for any of the map intervals studied. Previous localization of
D10S5 and
RBP3 to the proximal region of the long arm and the pericentric region, respectively, comparison of results with other studies, and our preliminary results with other chromosome 10 markers suggest that the
D10S4 end of the map extends into the long arm. Our linkage map has been constructed using only two-and three-locus analyses. It will be possible to combine our results with those of other groups to construct a more detailed and accurate genetic map of chromosome 10.</description><subject>Alleles</subject><subject>Chromosomes, Human, Pair 10</subject><subject>DNA Restriction Enzymes</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Linkage</subject><subject>Genetic Markers - analysis</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Multiple Endocrine Neoplasia - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Sex Factors</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotVb_gUJWoovRPGbycCGU-oSim-5DJpO0sTOTmnQK_nuntnTp6sA9597L-QC4xOgOI8zukRAi40VOb4S4lf2EZOgIDDESMhMsZ8dgeIicgrOUvhBCkgoyAAMiEUN5MQQPY1j7dqnnFs5j6FYwOOj8xsKnjzFsdFzamGBo4aJrdAvNIoYmpNBYiNE5OHG6TvZiryMwe3meTd6y6efr-2Q8zQzhZJ1hxh0TpkDMSCQdl1ZqRwukuZEip47QkpaYO-mcxoxKhgmpTFkaXBW81HQErndnVzF8dzatVeOTsXWtWxu6pLhgBRa86IP5LmhiSClap1bR9xV-FEZqS0xtcagtDtXrHzGF-rWr_f2ubGx1WNoj6v3HnW_7jhtvo0rG29bYykdr1qoK_v8HvyoGeH4</recordid><startdate>198807</startdate><enddate>198807</enddate><creator>Farrer, L.A.</creator><creator>Castiglione, C.M.</creator><creator>Kidd, J.R.</creator><creator>Myers, S.</creator><creator>Carson, N.</creator><creator>Simpson, N.E.</creator><creator>Kidd, K.K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198807</creationdate><title>A linkage group of five DNA markers on human chromosome 10</title><author>Farrer, L.A. ; Castiglione, C.M. ; Kidd, J.R. ; Myers, S. ; Carson, N. ; Simpson, N.E. ; Kidd, K.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-167f68c506c909f79e9af350a7c9843f23b3b17f9ffa16396122dcbbc1d57ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alleles</topic><topic>Chromosomes, Human, Pair 10</topic><topic>DNA Restriction Enzymes</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Linkage</topic><topic>Genetic Markers - analysis</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Multiple Endocrine Neoplasia - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrer, L.A.</creatorcontrib><creatorcontrib>Castiglione, C.M.</creatorcontrib><creatorcontrib>Kidd, J.R.</creatorcontrib><creatorcontrib>Myers, S.</creatorcontrib><creatorcontrib>Carson, N.</creatorcontrib><creatorcontrib>Simpson, N.E.</creatorcontrib><creatorcontrib>Kidd, K.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrer, L.A.</au><au>Castiglione, C.M.</au><au>Kidd, J.R.</au><au>Myers, S.</au><au>Carson, N.</au><au>Simpson, N.E.</au><au>Kidd, K.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A linkage group of five DNA markers on human chromosome 10</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1988-07</date><risdate>1988</risdate><volume>3</volume><issue>1</issue><spage>72</spage><epage>77</epage><pages>72-77</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Five chromosome 10 DNA markers (
D10S1,
D10S3,
D10S4,
D10S5, and
RBP3) were typed in five large pedigrees with multiple endocrine neoplasia type 2A (MEN-2A) and in five non-MEN-2A pedigrees. Linkage analyses showed that these loci and the locus for MEN-2A (
MEN2A) are in one linkage group spanning at least 70 cM. The order of the marker loci is
RBP3-D10S5-D10S3-D10S1-D10S4, with interlocus recombination frequencies of 7, 13–19, 19, and 19%, respectively, all on the same side of
MEN2A. Analyses of sex-specific recombination frequencies indicated no significant differences between males and females for any of the map intervals studied. Previous localization of
D10S5 and
RBP3 to the proximal region of the long arm and the pericentric region, respectively, comparison of results with other studies, and our preliminary results with other chromosome 10 markers suggest that the
D10S4 end of the map extends into the long arm. Our linkage map has been constructed using only two-and three-locus analyses. It will be possible to combine our results with those of other groups to construct a more detailed and accurate genetic map of chromosome 10.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2906045</pmid><doi>10.1016/0888-7543(88)90162-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1988-07, Vol.3 (1), p.72-77 |
| issn | 0888-7543 1089-8646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78651875 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles Chromosomes, Human, Pair 10 DNA Restriction Enzymes Female Gene Frequency Genetic Linkage Genetic Markers - analysis Haplotypes Humans Male Multiple Endocrine Neoplasia - genetics Polymorphism, Genetic Polymorphism, Restriction Fragment Length Sex Factors |
| title | A linkage group of five DNA markers on human chromosome 10 |
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