Elastase-induced hydrolysis of synthetic solid substrates: poly(ester-urea-urethane) and poly(ether-urea-urethane)
Human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane) containing [ 14C]toluene diisocyanate ([14C]TDI), poly(caprolactone) (PCL) and ethylenediamine (ED), and a poly(ether-urea-urethane) containi...
Gespeichert in:
Veröffentlicht in: | Biomaterials 1996-12, Vol.17 (24), p.2381-2388 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 2388 |
---|---|
container_issue | 24 |
container_start_page | 2381 |
container_title | Biomaterials |
container_volume | 17 |
creator | Labow, Rosalind S. Erfle, Douglas J. Santerre, J.Paul |
description | Human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane) containing [
14C]toluene diisocyanate ([14C]TDI), poly(caprolactone) (PCL) and ethylenediamine (ED), and a poly(ether-urea-urethane) containing [
14C]TDI, poly(tetramethylene oxide) (PTMO) and ED. Ten-fold more radioactive carbon was released when PPE was incubated with [
14C]TDI/PCL/ED than when HNE was used. The PPE-induced radioactive carbon release was significantly reduced by a specific elastase inhibitor. Ten-fold less radioactive carbon was released when [
14
C]TDI/PTMO/ED was incubated with PPE as compared to [
14C]TDI/PCL/ED. Since neutrophils, which contain elastolytic activity, are present during the inflammatory response, the stability of biomaterials used in implanted devices may be affected. |
doi_str_mv | 10.1016/S0142-9612(96)00088-9 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78651672</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0142961296000889</els_id><sourcerecordid>78651672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-57fbaa3fb879a8e6440ea0db4c8c9732d019bcde598bc516c0a9712c6f52930e3</originalsourceid><addsrcrecordid>eNqFkU9r3DAQxUVpSbdpP0LAh1KSg9uRbFlSL6GE9A8Eemh7FrI0ZlW89lYjF_bbV5s1e-gllxHi_Z70mMfYFYf3HHj34QfwVtSm4-LadDcAoHVtnrEN10rX0oB8zjZn5CV7RfQbyh1accEutNGiVWbD0v3oKDvCOk5h8Riq7SGkeTxQpGoeKjpMeYs5-ormMYaKlp5ychnpY7Uv2DVSxlQvCd1x5K2b8KZyU1jVYv5ffc1eDG4kfLOel-zX5_ufd1_rh-9fvt19eqh9KyDXUg29c83Qa2Wcxq5tAR2EvvXaG9WIANz0PqA0uveSdx6cUVz4bpDCNIDNJXt3enef5j9LyWl3kTyOYwkxL2SV7opNiSdBLg1XBkwB5Qn0aSZKONh9ijuXDpaDPZZiH0uxx42XYR9LsUff1frB0u8wnF1rC0V_u-qOvBuH5CYf6YwJ2fDG6ILdnjAsW_sbMVnyEadSWkzosw1zfCLIP0Mwqt0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15917909</pqid></control><display><type>article</type><title>Elastase-induced hydrolysis of synthetic solid substrates: poly(ester-urea-urethane) and poly(ether-urea-urethane)</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Labow, Rosalind S. ; Erfle, Douglas J. ; Santerre, J.Paul</creator><creatorcontrib>Labow, Rosalind S. ; Erfle, Douglas J. ; Santerre, J.Paul</creatorcontrib><description>Human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane) containing [
14C]toluene diisocyanate ([14C]TDI), poly(caprolactone) (PCL) and ethylenediamine (ED), and a poly(ether-urea-urethane) containing [
14C]TDI, poly(tetramethylene oxide) (PTMO) and ED. Ten-fold more radioactive carbon was released when PPE was incubated with [
14C]TDI/PCL/ED than when HNE was used. The PPE-induced radioactive carbon release was significantly reduced by a specific elastase inhibitor. Ten-fold less radioactive carbon was released when [
14
C]TDI/PTMO/ED was incubated with PPE as compared to [
14C]TDI/PCL/ED. Since neutrophils, which contain elastolytic activity, are present during the inflammatory response, the stability of biomaterials used in implanted devices may be affected.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(96)00088-9</identifier><identifier>PMID: 8982479</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; biodegradation ; Biological and medical sciences ; Carbon Radioisotopes ; Enzyme Inhibitors - pharmacology ; human elastase ; Humans ; Hydrolysis ; inflammatory response ; Leukocyte Elastase - antagonists & inhibitors ; Leukocyte Elastase - metabolism ; Medical sciences ; neutrophil ; Oligopeptides - pharmacology ; Pancreatic Elastase - antagonists & inhibitors ; Pancreatic Elastase - metabolism ; Poly(urethane)s ; Polyesters - metabolism ; Polymers - metabolism ; Polyurethanes - metabolism ; porcine elastase ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Substrate Specificity ; Swine ; Technology. Biomaterials. Equipments. Material. Instrumentation ; Trypsin - metabolism ; Trypsin - pharmacology</subject><ispartof>Biomaterials, 1996-12, Vol.17 (24), p.2381-2388</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-57fbaa3fb879a8e6440ea0db4c8c9732d019bcde598bc516c0a9712c6f52930e3</citedby><cites>FETCH-LOGICAL-c420t-57fbaa3fb879a8e6440ea0db4c8c9732d019bcde598bc516c0a9712c6f52930e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961296000889$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2531398$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8982479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Labow, Rosalind S.</creatorcontrib><creatorcontrib>Erfle, Douglas J.</creatorcontrib><creatorcontrib>Santerre, J.Paul</creatorcontrib><title>Elastase-induced hydrolysis of synthetic solid substrates: poly(ester-urea-urethane) and poly(ether-urea-urethane)</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane) containing [
14C]toluene diisocyanate ([14C]TDI), poly(caprolactone) (PCL) and ethylenediamine (ED), and a poly(ether-urea-urethane) containing [
14C]TDI, poly(tetramethylene oxide) (PTMO) and ED. Ten-fold more radioactive carbon was released when PPE was incubated with [
14C]TDI/PCL/ED than when HNE was used. The PPE-induced radioactive carbon release was significantly reduced by a specific elastase inhibitor. Ten-fold less radioactive carbon was released when [
14
C]TDI/PTMO/ED was incubated with PPE as compared to [
14C]TDI/PCL/ED. Since neutrophils, which contain elastolytic activity, are present during the inflammatory response, the stability of biomaterials used in implanted devices may be affected.</description><subject>Animals</subject><subject>biodegradation</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>human elastase</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>inflammatory response</subject><subject>Leukocyte Elastase - antagonists & inhibitors</subject><subject>Leukocyte Elastase - metabolism</subject><subject>Medical sciences</subject><subject>neutrophil</subject><subject>Oligopeptides - pharmacology</subject><subject>Pancreatic Elastase - antagonists & inhibitors</subject><subject>Pancreatic Elastase - metabolism</subject><subject>Poly(urethane)s</subject><subject>Polyesters - metabolism</subject><subject>Polymers - metabolism</subject><subject>Polyurethanes - metabolism</subject><subject>porcine elastase</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Substrate Specificity</subject><subject>Swine</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><subject>Trypsin - metabolism</subject><subject>Trypsin - pharmacology</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVpSbdpP0LAh1KSg9uRbFlSL6GE9A8Eemh7FrI0ZlW89lYjF_bbV5s1e-gllxHi_Z70mMfYFYf3HHj34QfwVtSm4-LadDcAoHVtnrEN10rX0oB8zjZn5CV7RfQbyh1accEutNGiVWbD0v3oKDvCOk5h8Riq7SGkeTxQpGoeKjpMeYs5-ormMYaKlp5ychnpY7Uv2DVSxlQvCd1x5K2b8KZyU1jVYv5ffc1eDG4kfLOel-zX5_ufd1_rh-9fvt19eqh9KyDXUg29c83Qa2Wcxq5tAR2EvvXaG9WIANz0PqA0uveSdx6cUVz4bpDCNIDNJXt3enef5j9LyWl3kTyOYwkxL2SV7opNiSdBLg1XBkwB5Qn0aSZKONh9ijuXDpaDPZZiH0uxx42XYR9LsUff1frB0u8wnF1rC0V_u-qOvBuH5CYf6YwJ2fDG6ILdnjAsW_sbMVnyEadSWkzosw1zfCLIP0Mwqt0</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Labow, Rosalind S.</creator><creator>Erfle, Douglas J.</creator><creator>Santerre, J.Paul</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Elastase-induced hydrolysis of synthetic solid substrates: poly(ester-urea-urethane) and poly(ether-urea-urethane)</title><author>Labow, Rosalind S. ; Erfle, Douglas J. ; Santerre, J.Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-57fbaa3fb879a8e6440ea0db4c8c9732d019bcde598bc516c0a9712c6f52930e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>biodegradation</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>human elastase</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>inflammatory response</topic><topic>Leukocyte Elastase - antagonists & inhibitors</topic><topic>Leukocyte Elastase - metabolism</topic><topic>Medical sciences</topic><topic>neutrophil</topic><topic>Oligopeptides - pharmacology</topic><topic>Pancreatic Elastase - antagonists & inhibitors</topic><topic>Pancreatic Elastase - metabolism</topic><topic>Poly(urethane)s</topic><topic>Polyesters - metabolism</topic><topic>Polymers - metabolism</topic><topic>Polyurethanes - metabolism</topic><topic>porcine elastase</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Substrate Specificity</topic><topic>Swine</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><topic>Trypsin - metabolism</topic><topic>Trypsin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labow, Rosalind S.</creatorcontrib><creatorcontrib>Erfle, Douglas J.</creatorcontrib><creatorcontrib>Santerre, J.Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labow, Rosalind S.</au><au>Erfle, Douglas J.</au><au>Santerre, J.Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elastase-induced hydrolysis of synthetic solid substrates: poly(ester-urea-urethane) and poly(ether-urea-urethane)</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>17</volume><issue>24</issue><spage>2381</spage><epage>2388</epage><pages>2381-2388</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane) containing [
14C]toluene diisocyanate ([14C]TDI), poly(caprolactone) (PCL) and ethylenediamine (ED), and a poly(ether-urea-urethane) containing [
14C]TDI, poly(tetramethylene oxide) (PTMO) and ED. Ten-fold more radioactive carbon was released when PPE was incubated with [
14C]TDI/PCL/ED than when HNE was used. The PPE-induced radioactive carbon release was significantly reduced by a specific elastase inhibitor. Ten-fold less radioactive carbon was released when [
14
C]TDI/PTMO/ED was incubated with PPE as compared to [
14C]TDI/PCL/ED. Since neutrophils, which contain elastolytic activity, are present during the inflammatory response, the stability of biomaterials used in implanted devices may be affected.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8982479</pmid><doi>10.1016/S0142-9612(96)00088-9</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0142-9612 |
ispartof | Biomaterials, 1996-12, Vol.17 (24), p.2381-2388 |
issn | 0142-9612 1878-5905 |
language | eng |
recordid | cdi_proquest_miscellaneous_78651672 |
source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Animals biodegradation Biological and medical sciences Carbon Radioisotopes Enzyme Inhibitors - pharmacology human elastase Humans Hydrolysis inflammatory response Leukocyte Elastase - antagonists & inhibitors Leukocyte Elastase - metabolism Medical sciences neutrophil Oligopeptides - pharmacology Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - metabolism Poly(urethane)s Polyesters - metabolism Polymers - metabolism Polyurethanes - metabolism porcine elastase Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Substrate Specificity Swine Technology. Biomaterials. Equipments. Material. Instrumentation Trypsin - metabolism Trypsin - pharmacology |
title | Elastase-induced hydrolysis of synthetic solid substrates: poly(ester-urea-urethane) and poly(ether-urea-urethane) |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T02%3A01%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elastase-induced%20hydrolysis%20of%20synthetic%20solid%20substrates:%20poly(ester-urea-urethane)%20and%20poly(ether-urea-urethane)&rft.jtitle=Biomaterials&rft.au=Labow,%20Rosalind%20S.&rft.date=1996-12-01&rft.volume=17&rft.issue=24&rft.spage=2381&rft.epage=2388&rft.pages=2381-2388&rft.issn=0142-9612&rft.eissn=1878-5905&rft_id=info:doi/10.1016/S0142-9612(96)00088-9&rft_dat=%3Cproquest_cross%3E78651672%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15917909&rft_id=info:pmid/8982479&rft_els_id=S0142961296000889&rfr_iscdi=true |