Molecular Recognition by Cholesterol Esterase of Active Site Ligands:  Structure−Reactivity Effects for Inhibition by Aryl Carbamates and Subsequent Carbamylenzyme Turnover

Interactions of mammalian pancreatic cholesterol esterases from pig and rat with a family of aryl carbamates C n H2 n +1NHCOOAr [n = 4−9; Ar = phenyl, p-X-phenyl (X = acetamido, bromo, fluoro, nitro, trifluoromethyl), 2-naphthyl, 2-tetrahydronaphthyl, estronyl] have been investigated, with an aim of...

Ausführliche Beschreibung