Role of oxygen-derived free radicals in gastric mucosal lesions induced by burn injury in rats
This study examined the role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions induced by burn injury in rats. Superoxide dismutase (SOD), catalase and combinations of SOD and catalase reduced ulcer index; in addition, SOD and catalase alone inhibited lipid peroxidation...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1988, Vol.85(11), pp.2372-2379 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
| container_volume | 85 |
| creator | YOSHIDA, Norimasa YOSHIKAWA, Toshikazu NAITO, Yuji OYAMADA, Hirokazu UEDA, Sigenobu TANIGAWA, Tohru TAKEMURA, Toshiki TAINAKA, Kenzo MORITA, Yutaka MIYAGAWA, Haruo SUGINO, Shigeru KONDO, Motoharu |
| description | This study examined the role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions induced by burn injury in rats. Superoxide dismutase (SOD), catalase and combinations of SOD and catalase reduced ulcer index; in addition, SOD and catalase alone inhibited lipid peroxidation in the gastric mucosa. SOD combined with catalase inhibited the volume of gastric juice and acid output, but had no effects on the pH of gastric juice, total acidity, gastric blood flow or hexosamine contents in the gastric mucosa. Ulcer index was reduced in rats treated with allopurinol, but not in polymorphonuclear leukocytes-depleted rats. These results indicate that oxygen-derived free radicals from xanthine oxidase and lipid peroxidation play an important role in the pathogenesis of gastric mucosal lesions induced by burn injury in rats. |
| doi_str_mv | 10.11405/nisshoshi1964.85.2372 |
| format | Article |
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Superoxide dismutase (SOD), catalase and combinations of SOD and catalase reduced ulcer index; in addition, SOD and catalase alone inhibited lipid peroxidation in the gastric mucosa. SOD combined with catalase inhibited the volume of gastric juice and acid output, but had no effects on the pH of gastric juice, total acidity, gastric blood flow or hexosamine contents in the gastric mucosa. Ulcer index was reduced in rats treated with allopurinol, but not in polymorphonuclear leukocytes-depleted rats. These results indicate that oxygen-derived free radicals from xanthine oxidase and lipid peroxidation play an important role in the pathogenesis of gastric mucosal lesions induced by burn injury in rats.</description><identifier>ISSN: 0446-6586</identifier><identifier>EISSN: 1349-7693</identifier><identifier>DOI: 10.11405/nisshoshi1964.85.2372</identifier><identifier>PMID: 3221491</identifier><language>jpn</language><publisher>Japan: The Japanese Society of Gastroenterology</publisher><subject>Animals ; Burns - complications ; Burns - metabolism ; Catalase - metabolism ; Female ; Free Radicals ; Gastric Mucosa - metabolism ; Lipid Peroxidation ; Oxygen - metabolism ; Oxygen - physiology ; Rats ; Rats, Inbred Strains ; Stomach Ulcer - etiology ; Stomach Ulcer - metabolism ; Superoxide Dismutase - metabolism</subject><ispartof>Nippon Shokakibyo Gakkai Zasshi, 1988, Vol.85(11), pp.2372-2379</ispartof><rights>The Japanese Society of Gastroenterology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3221491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIDA, Norimasa</creatorcontrib><creatorcontrib>YOSHIKAWA, Toshikazu</creatorcontrib><creatorcontrib>NAITO, Yuji</creatorcontrib><creatorcontrib>OYAMADA, Hirokazu</creatorcontrib><creatorcontrib>UEDA, Sigenobu</creatorcontrib><creatorcontrib>TANIGAWA, Tohru</creatorcontrib><creatorcontrib>TAKEMURA, Toshiki</creatorcontrib><creatorcontrib>TAINAKA, Kenzo</creatorcontrib><creatorcontrib>MORITA, Yutaka</creatorcontrib><creatorcontrib>MIYAGAWA, Haruo</creatorcontrib><creatorcontrib>SUGINO, Shigeru</creatorcontrib><creatorcontrib>KONDO, Motoharu</creatorcontrib><title>Role of oxygen-derived free radicals in gastric mucosal lesions induced by burn injury in rats</title><title>Nippon Shokakibyo Gakkai Zasshi</title><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><description>This study examined the role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions induced by burn injury in rats. Superoxide dismutase (SOD), catalase and combinations of SOD and catalase reduced ulcer index; in addition, SOD and catalase alone inhibited lipid peroxidation in the gastric mucosa. SOD combined with catalase inhibited the volume of gastric juice and acid output, but had no effects on the pH of gastric juice, total acidity, gastric blood flow or hexosamine contents in the gastric mucosa. Ulcer index was reduced in rats treated with allopurinol, but not in polymorphonuclear leukocytes-depleted rats. These results indicate that oxygen-derived free radicals from xanthine oxidase and lipid peroxidation play an important role in the pathogenesis of gastric mucosal lesions induced by burn injury in rats.</description><subject>Animals</subject><subject>Burns - complications</subject><subject>Burns - metabolism</subject><subject>Catalase - metabolism</subject><subject>Female</subject><subject>Free Radicals</subject><subject>Gastric Mucosa - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Oxygen - metabolism</subject><subject>Oxygen - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stomach Ulcer - etiology</subject><subject>Stomach Ulcer - metabolism</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUUtLAzEQDqLUUvsTlJy8bU02j02OIr6gIIheDdnsbJuyj5rsivvv3dKl4BxmGL4HwzcI3VCyopQTcdf4GLdt3HqqJV8psUpZlp6hOWVcJ5nU7BzNCecykULJS7SM0eeEEC20YmyGZixNKdd0jr7e2wpwW-L2d9hAkxQQ_A8UuAwAONjCO1tF7Bu8sbEL3uG6d220Fa4g-rY5QEXvRkE-4LwPzbjv-jAcFMF28QpdlKMBLKe5QJ9Pjx8PL8n67fn14X6d7FKedQnTSolyPI-XhaTEqozkmXRMltRBDorlILK8JEJLyXXKtCPKCSILzcYSli3Q7dF3H9rvHmJnah8dVJVtoO2jyZQUlDI6Eq8nYp_XUJh98LUNg5kCGfH1Ed_Fzm7ghNvQeVeB-Re8UcJQOvXDB040t7XBQMP-AGwCgTA</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>YOSHIDA, Norimasa</creator><creator>YOSHIKAWA, Toshikazu</creator><creator>NAITO, Yuji</creator><creator>OYAMADA, Hirokazu</creator><creator>UEDA, Sigenobu</creator><creator>TANIGAWA, Tohru</creator><creator>TAKEMURA, Toshiki</creator><creator>TAINAKA, Kenzo</creator><creator>MORITA, Yutaka</creator><creator>MIYAGAWA, Haruo</creator><creator>SUGINO, Shigeru</creator><creator>KONDO, Motoharu</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Role of oxygen-derived free radicals in gastric mucosal lesions induced by burn injury in rats</title><author>YOSHIDA, Norimasa ; YOSHIKAWA, Toshikazu ; NAITO, Yuji ; OYAMADA, Hirokazu ; UEDA, Sigenobu ; TANIGAWA, Tohru ; TAKEMURA, Toshiki ; TAINAKA, Kenzo ; MORITA, Yutaka ; MIYAGAWA, Haruo ; SUGINO, Shigeru ; KONDO, Motoharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j247t-39885f0954fd610a870b76c36f1cebe83be57bf0596649239c08c506d933335a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Burns - complications</topic><topic>Burns - metabolism</topic><topic>Catalase - metabolism</topic><topic>Female</topic><topic>Free Radicals</topic><topic>Gastric Mucosa - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Oxygen - metabolism</topic><topic>Oxygen - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach Ulcer - etiology</topic><topic>Stomach Ulcer - metabolism</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>YOSHIDA, Norimasa</creatorcontrib><creatorcontrib>YOSHIKAWA, Toshikazu</creatorcontrib><creatorcontrib>NAITO, Yuji</creatorcontrib><creatorcontrib>OYAMADA, Hirokazu</creatorcontrib><creatorcontrib>UEDA, Sigenobu</creatorcontrib><creatorcontrib>TANIGAWA, Tohru</creatorcontrib><creatorcontrib>TAKEMURA, Toshiki</creatorcontrib><creatorcontrib>TAINAKA, Kenzo</creatorcontrib><creatorcontrib>MORITA, Yutaka</creatorcontrib><creatorcontrib>MIYAGAWA, Haruo</creatorcontrib><creatorcontrib>SUGINO, Shigeru</creatorcontrib><creatorcontrib>KONDO, Motoharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIDA, Norimasa</au><au>YOSHIKAWA, Toshikazu</au><au>NAITO, Yuji</au><au>OYAMADA, Hirokazu</au><au>UEDA, Sigenobu</au><au>TANIGAWA, Tohru</au><au>TAKEMURA, Toshiki</au><au>TAINAKA, Kenzo</au><au>MORITA, Yutaka</au><au>MIYAGAWA, Haruo</au><au>SUGINO, Shigeru</au><au>KONDO, Motoharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of oxygen-derived free radicals in gastric mucosal lesions induced by burn injury in rats</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1988</date><risdate>1988</risdate><volume>85</volume><issue>11</issue><spage>2372</spage><epage>2379</epage><pages>2372-2379</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>This study examined the role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions induced by burn injury in rats. Superoxide dismutase (SOD), catalase and combinations of SOD and catalase reduced ulcer index; in addition, SOD and catalase alone inhibited lipid peroxidation in the gastric mucosa. SOD combined with catalase inhibited the volume of gastric juice and acid output, but had no effects on the pH of gastric juice, total acidity, gastric blood flow or hexosamine contents in the gastric mucosa. Ulcer index was reduced in rats treated with allopurinol, but not in polymorphonuclear leukocytes-depleted rats. These results indicate that oxygen-derived free radicals from xanthine oxidase and lipid peroxidation play an important role in the pathogenesis of gastric mucosal lesions induced by burn injury in rats.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>3221491</pmid><doi>10.11405/nisshoshi1964.85.2372</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1988, Vol.85(11), pp.2372-2379 |
| issn | 0446-6586 1349-7693 |
| language | jpn |
| recordid | cdi_proquest_miscellaneous_78651131 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Burns - complications Burns - metabolism Catalase - metabolism Female Free Radicals Gastric Mucosa - metabolism Lipid Peroxidation Oxygen - metabolism Oxygen - physiology Rats Rats, Inbred Strains Stomach Ulcer - etiology Stomach Ulcer - metabolism Superoxide Dismutase - metabolism |
| title | Role of oxygen-derived free radicals in gastric mucosal lesions induced by burn injury in rats |
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