Estrogen receptor distribution in the peripheral, intermediate and central regions of breast cancers
The central, intermediate and peripheral regions of 25 breast tumors were analyzed for estrogen receptors (ER) using a combined biochemical (BC)/immunohistochemical (IHC) micromethod. To optimize the regional comparison, the percentage carcinoma per sample (PCS) was evaluated and incorporated into t...
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| Veröffentlicht in: | European journal of cancer & clinical oncology 1988-12, Vol.24 (12), p.1885-1889 |
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| container_end_page | 1889 |
|---|---|
| container_issue | 12 |
| container_start_page | 1885 |
| container_title | European journal of cancer & clinical oncology |
| container_volume | 24 |
| creator | van Netten, Johannes P. Armstrong, Jane B. Carlyle, Sheila S. Goodchild, Nancy L. Thorton, Ian G. Brigden, Malcolm L. Coy, Peter Fletcher, Christine |
| description | The central, intermediate and peripheral regions of
25 breast tumors were analyzed for estrogen receptors (ER) using a combined biochemical (BC)/immunohistochemical (IHC) micromethod. To optimize the regional comparison, the percentage carcinoma per sample (PCS) was evaluated and incorporated into the quantification of the ER.
Correction of the measured ER for the PCS eliminated differences in receptor levels between the central and peripheral regions but not the intermediate region. Although the corrected BC-ER level in this region was found to be about
20% higher, the IHC method did not detect such a difference. Determination of the ER status at the actual growth front of a tumor, rather than in the intermediate region where ER levels appear to be highest, may be of greater clinical relevance. Intra-regional ER heterogeneity appears, however, to be particularly pronounced in this area of a tumor. |
| doi_str_mv | 10.1016/0277-5379(88)90102-2 |
| format | Article |
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25 breast tumors were analyzed for estrogen receptors (ER) using a combined biochemical (BC)/immunohistochemical (IHC) micromethod. To optimize the regional comparison, the percentage carcinoma per sample (PCS) was evaluated and incorporated into the quantification of the ER.
Correction of the measured ER for the PCS eliminated differences in receptor levels between the central and peripheral regions but not the intermediate region. Although the corrected BC-ER level in this region was found to be about
20% higher, the IHC method did not detect such a difference. Determination of the ER status at the actual growth front of a tumor, rather than in the intermediate region where ER levels appear to be highest, may be of greater clinical relevance. Intra-regional ER heterogeneity appears, however, to be particularly pronounced in this area of a tumor.</description><identifier>ISSN: 0277-5379</identifier><identifier>DOI: 10.1016/0277-5379(88)90102-2</identifier><identifier>PMID: 3220085</identifier><identifier>CODEN: EJCODS</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Breast Neoplasms - analysis ; Breast Neoplasms - pathology ; carcinoma ; estrogens ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Receptors, Estrogen - analysis</subject><ispartof>European journal of cancer & clinical oncology, 1988-12, Vol.24 (12), p.1885-1889</ispartof><rights>1988</rights><rights>1991 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-fae510c9714c06c0fecde245787612bee61042b575740522d3fe649be9f91da53</citedby><cites>FETCH-LOGICAL-c418t-fae510c9714c06c0fecde245787612bee61042b575740522d3fe649be9f91da53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19800013$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3220085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Netten, Johannes P.</creatorcontrib><creatorcontrib>Armstrong, Jane B.</creatorcontrib><creatorcontrib>Carlyle, Sheila S.</creatorcontrib><creatorcontrib>Goodchild, Nancy L.</creatorcontrib><creatorcontrib>Thorton, Ian G.</creatorcontrib><creatorcontrib>Brigden, Malcolm L.</creatorcontrib><creatorcontrib>Coy, Peter</creatorcontrib><creatorcontrib>Fletcher, Christine</creatorcontrib><title>Estrogen receptor distribution in the peripheral, intermediate and central regions of breast cancers</title><title>European journal of cancer & clinical oncology</title><addtitle>Eur J Cancer Clin Oncol</addtitle><description>The central, intermediate and peripheral regions of
25 breast tumors were analyzed for estrogen receptors (ER) using a combined biochemical (BC)/immunohistochemical (IHC) micromethod. To optimize the regional comparison, the percentage carcinoma per sample (PCS) was evaluated and incorporated into the quantification of the ER.
Correction of the measured ER for the PCS eliminated differences in receptor levels between the central and peripheral regions but not the intermediate region. Although the corrected BC-ER level in this region was found to be about
20% higher, the IHC method did not detect such a difference. Determination of the ER status at the actual growth front of a tumor, rather than in the intermediate region where ER levels appear to be highest, may be of greater clinical relevance. Intra-regional ER heterogeneity appears, however, to be particularly pronounced in this area of a tumor.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - analysis</subject><subject>Breast Neoplasms - pathology</subject><subject>carcinoma</subject><subject>estrogens</subject><subject>Female</subject><subject>Gynecology. Andrology. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Estrogen - analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>van Netten, Johannes P.</creatorcontrib><creatorcontrib>Armstrong, Jane B.</creatorcontrib><creatorcontrib>Carlyle, Sheila S.</creatorcontrib><creatorcontrib>Goodchild, Nancy L.</creatorcontrib><creatorcontrib>Thorton, Ian G.</creatorcontrib><creatorcontrib>Brigden, Malcolm L.</creatorcontrib><creatorcontrib>Coy, Peter</creatorcontrib><creatorcontrib>Fletcher, Christine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer & clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Netten, Johannes P.</au><au>Armstrong, Jane B.</au><au>Carlyle, Sheila S.</au><au>Goodchild, Nancy L.</au><au>Thorton, Ian G.</au><au>Brigden, Malcolm L.</au><au>Coy, Peter</au><au>Fletcher, Christine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen receptor distribution in the peripheral, intermediate and central regions of breast cancers</atitle><jtitle>European journal of cancer & clinical oncology</jtitle><addtitle>Eur J Cancer Clin Oncol</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>24</volume><issue>12</issue><spage>1885</spage><epage>1889</epage><pages>1885-1889</pages><issn>0277-5379</issn><coden>EJCODS</coden><abstract>The central, intermediate and peripheral regions of
25 breast tumors were analyzed for estrogen receptors (ER) using a combined biochemical (BC)/immunohistochemical (IHC) micromethod. To optimize the regional comparison, the percentage carcinoma per sample (PCS) was evaluated and incorporated into the quantification of the ER.
Correction of the measured ER for the PCS eliminated differences in receptor levels between the central and peripheral regions but not the intermediate region. Although the corrected BC-ER level in this region was found to be about
20% higher, the IHC method did not detect such a difference. Determination of the ER status at the actual growth front of a tumor, rather than in the intermediate region where ER levels appear to be highest, may be of greater clinical relevance. Intra-regional ER heterogeneity appears, however, to be particularly pronounced in this area of a tumor.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3220085</pmid><doi>10.1016/0277-5379(88)90102-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-5379 |
| ispartof | European journal of cancer & clinical oncology, 1988-12, Vol.24 (12), p.1885-1889 |
| issn | 0277-5379 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78650986 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Biological and medical sciences Breast Neoplasms - analysis Breast Neoplasms - pathology carcinoma estrogens Female Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Receptors, Estrogen - analysis |
| title | Estrogen receptor distribution in the peripheral, intermediate and central regions of breast cancers |
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