Hormonal Responses to Analgesic Nitrous Oxide in Man
Summary Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration = 48.8%) p...
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| Veröffentlicht in: | Hormone and metabolic research 1988-12, Vol.20 (12), p.751-754 |
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| container_title | Hormone and metabolic research |
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| creator | Gillman, M. A. Katzeff, I. Vermaak, W. J. H. Becker, P. J. Susani, E. |
| description | Summary
Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration = 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed. The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man. We have also confirmed the findings of other workers that cortisol levels may not always be correlated with ACTH levels. |
| doi_str_mv | 10.1055/s-2007-1010939 |
| format | Article |
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Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration = 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed. The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man. We have also confirmed the findings of other workers that cortisol levels may not always be correlated with ACTH levels.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1010939</identifier><identifier>PMID: 2851516</identifier><language>eng</language><publisher>Germany</publisher><subject>Adrenocorticotropic Hormone - blood ; Adult ; Analgesia ; Clinical ; Follicle Stimulating Hormone - blood ; Growth Hormone - blood ; Hormones - blood ; Humans ; Hydrocortisone - blood ; Male ; Nitrous Oxide - administration & dosage ; Nitrous Oxide - pharmacology ; Prolactin - blood</subject><ispartof>Hormone and metabolic research, 1988-12, Vol.20 (12), p.751-754</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-9ffd7c587f28fb3d5af24e60136217341a23f43ea494ac48185e2b84391429913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1010939.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2851516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillman, M. A.</creatorcontrib><creatorcontrib>Katzeff, I.</creatorcontrib><creatorcontrib>Vermaak, W. J. H.</creatorcontrib><creatorcontrib>Becker, P. J.</creatorcontrib><creatorcontrib>Susani, E.</creatorcontrib><title>Hormonal Responses to Analgesic Nitrous Oxide in Man</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration = 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed. The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man. We have also confirmed the findings of other workers that cortisol levels may not always be correlated with ACTH levels.</description><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adult</subject><subject>Analgesia</subject><subject>Clinical</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Growth Hormone - blood</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Nitrous Oxide - administration & dosage</subject><subject>Nitrous Oxide - pharmacology</subject><subject>Prolactin - blood</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LAzEQxYMotVav3oQ9eUvN5GM3OZaiVqgWRM8h3U10y-6mJrug_70pXbx5Gmbem8fjh9A1kDkQIe4ipoQUGAgQxdQJmgJnCnMq81M0JQQkFoSzc3QR4y6tXAGfoAmVAgTkU8RXPrS-M032auPed9HGrPfZIl0-bKzL7KXugx9itvmuK5vVXfZsukt05kwT7dU4Z-j94f5tucLrzePTcrHGJaOyx8q5qiiFLByVbssqYRzlNifAcgoF42Aoc5xZwxU3JZcghaVbmfoDp0oBm6HbY-4--K_Bxl63dSxt05jOpk66kLkgkhbJOD8ay-BjDNbpfahbE340EH3ApKM-YNIjpvRwMyYP29ZWf_aRS9LxUe8_a9tavfNDSEjif3m_s_FuIw</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Gillman, M. A.</creator><creator>Katzeff, I.</creator><creator>Vermaak, W. J. H.</creator><creator>Becker, P. J.</creator><creator>Susani, E.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Hormonal Responses to Analgesic Nitrous Oxide in Man</title><author>Gillman, M. A. ; Katzeff, I. ; Vermaak, W. J. H. ; Becker, P. J. ; Susani, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-9ffd7c587f28fb3d5af24e60136217341a23f43ea494ac48185e2b84391429913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adult</topic><topic>Analgesia</topic><topic>Clinical</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Growth Hormone - blood</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Male</topic><topic>Nitrous Oxide - administration & dosage</topic><topic>Nitrous Oxide - pharmacology</topic><topic>Prolactin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillman, M. A.</creatorcontrib><creatorcontrib>Katzeff, I.</creatorcontrib><creatorcontrib>Vermaak, W. J. H.</creatorcontrib><creatorcontrib>Becker, P. J.</creatorcontrib><creatorcontrib>Susani, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillman, M. A.</au><au>Katzeff, I.</au><au>Vermaak, W. J. H.</au><au>Becker, P. J.</au><au>Susani, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal Responses to Analgesic Nitrous Oxide in Man</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>20</volume><issue>12</issue><spage>751</spage><epage>754</epage><pages>751-754</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Summary
Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration = 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed. The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man. We have also confirmed the findings of other workers that cortisol levels may not always be correlated with ACTH levels.</abstract><cop>Germany</cop><pmid>2851516</pmid><doi>10.1055/s-2007-1010939</doi><tpages>4</tpages></addata></record> |
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| ispartof | Hormone and metabolic research, 1988-12, Vol.20 (12), p.751-754 |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adrenocorticotropic Hormone - blood Adult Analgesia Clinical Follicle Stimulating Hormone - blood Growth Hormone - blood Hormones - blood Humans Hydrocortisone - blood Male Nitrous Oxide - administration & dosage Nitrous Oxide - pharmacology Prolactin - blood |
| title | Hormonal Responses to Analgesic Nitrous Oxide in Man |
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