Effects of β -adrenergic blockade on insulin-mediated glucose disposal in hypertensive and normotensive rats
OBJECTIVETo evaluate the impact of β-adrenergic blockade in spontaneously hypertensive rats (SHR)and in their normotensive controls, Wistar-Kyoto (WKY) rats, on whole-body glucose disposal under metabolic steady state conditions, in unrestrained and conscious animals. METHODSHR (n=13) and WKY rats (...
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| Veröffentlicht in: | Journal of hypertension 1996-09, Vol.14 (9), p.1087-1092 |
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| container_title | Journal of hypertension |
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| creator | Farrace, Stefano Frontoni, Simona Gambardella, Sergio Menzinger, Guido Rossetti, Luciano |
| description | OBJECTIVETo evaluate the impact of β-adrenergic blockade in spontaneously hypertensive rats (SHR)and in their normotensive controls, Wistar-Kyoto (WKY) rats, on whole-body glucose disposal under metabolic steady state conditions, in unrestrained and conscious animals.
METHODSHR (n=13) and WKY rats (n=12) underwent a 240 min insulinaemic clamp study with or without a superinfusion (120th to 240th minutes; second step) of propranolol.
RESULTSFrom 0 to 120 min (the first step) SHR showed significantly increased glucose uptake, muscle glycogen synthesis and glycogen synthase activity compared with WKY rats. When propranolol was superinfused, glucose uptake and muscle glycogen synthesis in SHR returned to levels similar to those observed in WKY rats during the first step. No significant differences were found for whole-body glycolysis in SHR and WKY in the first and second steps.
CONCLUSIONHypertensive rats display an increased insulin sensitivity compared with controls. β-Blockade is associated with a reduction in overall glucose metabolism in SHR, but not in WKY rats. |
| doi_str_mv | 10.1097/00004872-199609000-00007 |
| format | Article |
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METHODSHR (n=13) and WKY rats (n=12) underwent a 240 min insulinaemic clamp study with or without a superinfusion (120th to 240th minutes; second step) of propranolol.
RESULTSFrom 0 to 120 min (the first step) SHR showed significantly increased glucose uptake, muscle glycogen synthesis and glycogen synthase activity compared with WKY rats. When propranolol was superinfused, glucose uptake and muscle glycogen synthesis in SHR returned to levels similar to those observed in WKY rats during the first step. No significant differences were found for whole-body glycolysis in SHR and WKY in the first and second steps.
CONCLUSIONHypertensive rats display an increased insulin sensitivity compared with controls. β-Blockade is associated with a reduction in overall glucose metabolism in SHR, but not in WKY rats.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/00004872-199609000-00007</identifier><identifier>PMID: 8986908</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Glucose - metabolism ; Glycogen Synthase - metabolism ; Hypertension - metabolism ; Insulin - pharmacology ; Medical sciences ; Propranolol - pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY</subject><ispartof>Journal of hypertension, 1996-09, Vol.14 (9), p.1087-1092</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3235243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8986908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farrace, Stefano</creatorcontrib><creatorcontrib>Frontoni, Simona</creatorcontrib><creatorcontrib>Gambardella, Sergio</creatorcontrib><creatorcontrib>Menzinger, Guido</creatorcontrib><creatorcontrib>Rossetti, Luciano</creatorcontrib><title>Effects of β -adrenergic blockade on insulin-mediated glucose disposal in hypertensive and normotensive rats</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVETo evaluate the impact of β-adrenergic blockade in spontaneously hypertensive rats (SHR)and in their normotensive controls, Wistar-Kyoto (WKY) rats, on whole-body glucose disposal under metabolic steady state conditions, in unrestrained and conscious animals.
METHODSHR (n=13) and WKY rats (n=12) underwent a 240 min insulinaemic clamp study with or without a superinfusion (120th to 240th minutes; second step) of propranolol.
RESULTSFrom 0 to 120 min (the first step) SHR showed significantly increased glucose uptake, muscle glycogen synthesis and glycogen synthase activity compared with WKY rats. When propranolol was superinfused, glucose uptake and muscle glycogen synthesis in SHR returned to levels similar to those observed in WKY rats during the first step. No significant differences were found for whole-body glycolysis in SHR and WKY in the first and second steps.
CONCLUSIONHypertensive rats display an increased insulin sensitivity compared with controls. β-Blockade is associated with a reduction in overall glucose metabolism in SHR, but not in WKY rats.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Glucose - metabolism</subject><subject>Glycogen Synthase - metabolism</subject><subject>Hypertension - metabolism</subject><subject>Insulin - pharmacology</subject><subject>Medical sciences</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctuFTEMhiMEKqeFR0DKArEL5DIzSZaoKhepEhtYjzyJ0xOamQzJDFVfiwfhmQjqoTu8sGX_nyz5NyFU8LeCW_2Ot-iMlkxYO3DbOvZ3pJ-Qg-i0Yn1vzVNy4HJQbFC9fE7Oa_3eCGO1OiNnxprBcnMg81UI6LZKc6C_f1EGvuCC5SY6OqXsbsEjzQuNS91TXNiMPsKGnt6k3eWK1Me65gqpEfR4v2LZcKnxJ1JYPF1ymfO_QYGtviDPAqSKL0_1gnz7cPX18hO7_vLx8-X7a7ZKwzVz0zS4oLgUkwGtZQCUvocgHDgcELtO9UEJ0xLnzuvgOE4SrPdBKgFaXZA3D3vXkn_sWLdxjtVhSrBg3uuozdBzLWwDX53AfWq3jWuJM5T78eRP01-fdKgOUiiwuFgfMSWbt51qWPeA3eW0Yam3ab_DMh4R0nYc__cs9QfGwojP</recordid><startdate>199609</startdate><enddate>199609</enddate><creator>Farrace, Stefano</creator><creator>Frontoni, Simona</creator><creator>Gambardella, Sergio</creator><creator>Menzinger, Guido</creator><creator>Rossetti, Luciano</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199609</creationdate><title>Effects of β -adrenergic blockade on insulin-mediated glucose disposal in hypertensive and normotensive rats</title><author>Farrace, Stefano ; Frontoni, Simona ; Gambardella, Sergio ; Menzinger, Guido ; Rossetti, Luciano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2807-cbb6cf3021b8a772fae2d5af1cace6ee4435f3185f300cd7fc0eb2a9ddf231a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Glucose - metabolism</topic><topic>Glycogen Synthase - metabolism</topic><topic>Hypertension - metabolism</topic><topic>Insulin - pharmacology</topic><topic>Medical sciences</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrace, Stefano</creatorcontrib><creatorcontrib>Frontoni, Simona</creatorcontrib><creatorcontrib>Gambardella, Sergio</creatorcontrib><creatorcontrib>Menzinger, Guido</creatorcontrib><creatorcontrib>Rossetti, Luciano</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrace, Stefano</au><au>Frontoni, Simona</au><au>Gambardella, Sergio</au><au>Menzinger, Guido</au><au>Rossetti, Luciano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of β -adrenergic blockade on insulin-mediated glucose disposal in hypertensive and normotensive rats</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>1996-09</date><risdate>1996</risdate><volume>14</volume><issue>9</issue><spage>1087</spage><epage>1092</epage><pages>1087-1092</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>OBJECTIVETo evaluate the impact of β-adrenergic blockade in spontaneously hypertensive rats (SHR)and in their normotensive controls, Wistar-Kyoto (WKY) rats, on whole-body glucose disposal under metabolic steady state conditions, in unrestrained and conscious animals.
METHODSHR (n=13) and WKY rats (n=12) underwent a 240 min insulinaemic clamp study with or without a superinfusion (120th to 240th minutes; second step) of propranolol.
RESULTSFrom 0 to 120 min (the first step) SHR showed significantly increased glucose uptake, muscle glycogen synthesis and glycogen synthase activity compared with WKY rats. When propranolol was superinfused, glucose uptake and muscle glycogen synthesis in SHR returned to levels similar to those observed in WKY rats during the first step. No significant differences were found for whole-body glycolysis in SHR and WKY in the first and second steps.
CONCLUSIONHypertensive rats display an increased insulin sensitivity compared with controls. β-Blockade is associated with a reduction in overall glucose metabolism in SHR, but not in WKY rats.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8986908</pmid><doi>10.1097/00004872-199609000-00007</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of hypertension, 1996-09, Vol.14 (9), p.1087-1092 |
| issn | 0263-6352 1473-5598 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adrenergic beta-Antagonists - pharmacology Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Glucose - metabolism Glycogen Synthase - metabolism Hypertension - metabolism Insulin - pharmacology Medical sciences Propranolol - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY |
| title | Effects of β -adrenergic blockade on insulin-mediated glucose disposal in hypertensive and normotensive rats |
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