Liver Enzyme Activity and Body Mass Index
Obesity has been identified as a risk factor for liver disease in a number of cross-sectional studies. We investigated the association of biochemical liver tests (BLTs) among male employees of The Dow Chemical Company who had participated in two consecutive health surveillance examinations. The acti...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 1996-12, Vol.38 (12), p.1248-1252 |
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| container_issue | 12 |
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| container_title | Journal of occupational and environmental medicine |
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| creator | Burns, Carol J. Boswell, Jeffrey M. Olsen, Geary W. |
| description | Obesity has been identified as a risk factor for liver disease in a number of cross-sectional studies. We investigated the association of biochemical liver tests (BLTs) among male employees of The Dow Chemical Company who had participated in two consecutive health surveillance examinations. The activity of three liver enzymes—alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase—were used as measures of liver injury. Body mass index was strongly associated with increased enzyme activity in both examinations. Alcohol consumption was similarly associated with higher BLT results. Body mass index remained significantly associated with each BLT after controlling for alcohol consumption, race, and age. When changes in the BLTs were investigated over time, the employees who gained weight showed a significant increase in alanine aminotransferase activity compared with those who did not gain weight. |
| doi_str_mv | 10.1097/00043764-199612000-00010 |
| format | Article |
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We investigated the association of biochemical liver tests (BLTs) among male employees of The Dow Chemical Company who had participated in two consecutive health surveillance examinations. The activity of three liver enzymes—alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase—were used as measures of liver injury. Body mass index was strongly associated with increased enzyme activity in both examinations. Alcohol consumption was similarly associated with higher BLT results. Body mass index remained significantly associated with each BLT after controlling for alcohol consumption, race, and age. When changes in the BLTs were investigated over time, the employees who gained weight showed a significant increase in alanine aminotransferase activity compared with those who did not gain weight.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/00043764-199612000-00010</identifier><identifier>PMID: 8978516</identifier><identifier>CODEN: JOEMFM</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Adult ; Alanine Transaminase - blood ; Alcohol Drinking - adverse effects ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biomarkers ; Body Mass Index ; Disease ; Enzymes ; Gastroenterology. Liver. Pancreas. Abdomen ; Health risk assessment ; Humans ; Linear Models ; Liver ; Liver Diseases - enzymology ; Liver Diseases - epidemiology ; Liver Diseases - prevention & control ; Liver Function Tests ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Men ; Obesity ; Obesity - complications ; Occupational hazards ; Occupational Health ; ORIGINAL ARTICLES ; Other diseases. Semiology ; Risk Factors ; Transferases - blood ; United States - epidemiology</subject><ispartof>Journal of occupational and environmental medicine, 1996-12, Vol.38 (12), p.1248-1252</ispartof><rights>Copyright © 1996 American College of Occupational and Environmental Medicine</rights><rights>Williams & Wilkins 1996. All Rights Reserved.</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Dec 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4330-7fdc4ce30517abe042b45c702384a47cfcc4cd4fc8addb2589ba394e803a399a3</citedby><cites>FETCH-LOGICAL-c4330-7fdc4ce30517abe042b45c702384a47cfcc4cd4fc8addb2589ba394e803a399a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44994874$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44994874$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2524770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8978516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burns, Carol J.</creatorcontrib><creatorcontrib>Boswell, Jeffrey M.</creatorcontrib><creatorcontrib>Olsen, Geary W.</creatorcontrib><title>Liver Enzyme Activity and Body Mass Index</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>Obesity has been identified as a risk factor for liver disease in a number of cross-sectional studies. We investigated the association of biochemical liver tests (BLTs) among male employees of The Dow Chemical Company who had participated in two consecutive health surveillance examinations. The activity of three liver enzymes—alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase—were used as measures of liver injury. Body mass index was strongly associated with increased enzyme activity in both examinations. Alcohol consumption was similarly associated with higher BLT results. Body mass index remained significantly associated with each BLT after controlling for alcohol consumption, race, and age. When changes in the BLTs were investigated over time, the employees who gained weight showed a significant increase in alanine aminotransferase activity compared with those who did not gain weight.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Body Mass Index</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Liver</subject><subject>Liver Diseases - enzymology</subject><subject>Liver Diseases - epidemiology</subject><subject>Liver Diseases - prevention & control</subject><subject>Liver Function Tests</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Occupational hazards</subject><subject>Occupational Health</subject><subject>ORIGINAL ARTICLES</subject><subject>Other diseases. Semiology</subject><subject>Risk Factors</subject><subject>Transferases - blood</subject><subject>United States - epidemiology</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1LwzAUhoMoc05_glBEBC-q-ThpksspfsHEG70OaZqyzq6dSavOX290c4LgRTgJ73PeE96DUELwGcFKnGOMgYkMUqJURmh8pvEQvIWGhLMs5QrkdrxjkaVUcLqL9kKYRYITzAdoIJWQnGRDdDqpXp1PrpqP5dwlY9tVr1W3TExTJBdtsUzuTQjJXVO49320U5o6uIN1HaGn66vHy9t08nBzdzmepBYYw6koCwvWMcyJMLnDQHPgVmDKJBgQtrRRLqC00hRFTrlUuWEKnMQsVmXYCJ2sfBe-feld6PS8CtbVtWlc2wctZAZKgorg0R9w1va-iX_TlNBMAZUQIbmCrG9D8K7UC1_NjV9qgvVXlPonSr2JUn9HGVsP1_59PnfFpnGdXdSP17oJ1tSlN42twgajnIIQXzawwt7aunM-PNf9m_N66kzdTfV_i_ydPgtd6zeuACquVgD7BO4Rkf0</recordid><startdate>199612</startdate><enddate>199612</enddate><creator>Burns, Carol J.</creator><creator>Boswell, Jeffrey M.</creator><creator>Olsen, Geary W.</creator><general>Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199612</creationdate><title>Liver Enzyme Activity and Body Mass Index</title><author>Burns, Carol J. ; Boswell, Jeffrey M. ; Olsen, Geary W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4330-7fdc4ce30517abe042b45c702384a47cfcc4cd4fc8addb2589ba394e803a399a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Body Mass Index</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Liver</topic><topic>Liver Diseases - enzymology</topic><topic>Liver Diseases - epidemiology</topic><topic>Liver Diseases - prevention & control</topic><topic>Liver Function Tests</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Occupational hazards</topic><topic>Occupational Health</topic><topic>ORIGINAL ARTICLES</topic><topic>Other diseases. Semiology</topic><topic>Risk Factors</topic><topic>Transferases - blood</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burns, Carol J.</creatorcontrib><creatorcontrib>Boswell, Jeffrey M.</creatorcontrib><creatorcontrib>Olsen, Geary W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burns, Carol J.</au><au>Boswell, Jeffrey M.</au><au>Olsen, Geary W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver Enzyme Activity and Body Mass Index</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>1996-12</date><risdate>1996</risdate><volume>38</volume><issue>12</issue><spage>1248</spage><epage>1252</epage><pages>1248-1252</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><coden>JOEMFM</coden><abstract>Obesity has been identified as a risk factor for liver disease in a number of cross-sectional studies. We investigated the association of biochemical liver tests (BLTs) among male employees of The Dow Chemical Company who had participated in two consecutive health surveillance examinations. The activity of three liver enzymes—alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase—were used as measures of liver injury. Body mass index was strongly associated with increased enzyme activity in both examinations. Alcohol consumption was similarly associated with higher BLT results. Body mass index remained significantly associated with each BLT after controlling for alcohol consumption, race, and age. When changes in the BLTs were investigated over time, the employees who gained weight showed a significant increase in alanine aminotransferase activity compared with those who did not gain weight.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>8978516</pmid><doi>10.1097/00043764-199612000-00010</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1076-2752 |
| ispartof | Journal of occupational and environmental medicine, 1996-12, Vol.38 (12), p.1248-1252 |
| issn | 1076-2752 1536-5948 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; Journals@Ovid Complete |
| subjects | Adult Alanine Transaminase - blood Alcohol Drinking - adverse effects Aspartate Aminotransferases - blood Biological and medical sciences Biomarkers Body Mass Index Disease Enzymes Gastroenterology. Liver. Pancreas. Abdomen Health risk assessment Humans Linear Models Liver Liver Diseases - enzymology Liver Diseases - epidemiology Liver Diseases - prevention & control Liver Function Tests Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Men Obesity Obesity - complications Occupational hazards Occupational Health ORIGINAL ARTICLES Other diseases. Semiology Risk Factors Transferases - blood United States - epidemiology |
| title | Liver Enzyme Activity and Body Mass Index |
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