Comparison of absorbable materials for surgical haemostasis
The haemostatic effect of two new materials has been compared with surgical gauze and oxidized cellulose using a standardized liver laceration in New Zealand White rabbits. Following excision of a 3 cm2 disc of tissue from the liver, 42 rabbits were randomized to the use of gauze swabs (n = 6), oxid...
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| Veröffentlicht in: | British journal of surgery 1988-10, Vol.75 (10), p.969-971 |
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| container_title | British journal of surgery |
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| creator | Blair, S. D. Backhouse, C. M. Harper, R. Matthews, J. McCollum, C. N. |
| description | The haemostatic effect of two new materials has been compared with surgical gauze and oxidized cellulose using a standardized liver laceration in New Zealand White rabbits. Following excision of a 3 cm2 disc of tissue from the liver, 42 rabbits were randomized to the use of gauze swabs (n = 6), oxidized cellulose (Surgicel®) (n = 12), porcine collagen (Medistat®) (n = 12) or calcium alginate (Kaltostat®) (n = 12) to control the resulting haemorrhage. Blood loss and time to haemostasis were accurately recorded. The absorbable materials were left in situ and animals killed between 2 weeks and 6 months later to examine speed of absorption and resulting adhesions. Calcium alginate stopped bleeding in 15min with gauze (P |
| doi_str_mv | 10.1002/bjs.1800751010 |
| format | Article |
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D. ; Backhouse, C. M. ; Harper, R. ; Matthews, J. ; McCollum, C. N.</creator><creatorcontrib>Blair, S. D. ; Backhouse, C. M. ; Harper, R. ; Matthews, J. ; McCollum, C. N.</creatorcontrib><description>The haemostatic effect of two new materials has been compared with surgical gauze and oxidized cellulose using a standardized liver laceration in New Zealand White rabbits. Following excision of a 3 cm2 disc of tissue from the liver, 42 rabbits were randomized to the use of gauze swabs (n = 6), oxidized cellulose (Surgicel®) (n = 12), porcine collagen (Medistat®) (n = 12) or calcium alginate (Kaltostat®) (n = 12) to control the resulting haemorrhage. Blood loss and time to haemostasis were accurately recorded. The absorbable materials were left in situ and animals killed between 2 weeks and 6 months later to examine speed of absorption and resulting adhesions. Calcium alginate stopped bleeding in <3 min in all animals compared with a mean (±s.e.m.) of 5.7 ± 0.75 min for porcine collagen, 12.5 ± 0.9 min for oxidized cellulose and > 15min with gauze (P<0.001). Oxidized cellulose and calcium alginate reabsorbed within 3 months leaving a fibrous scar, but a vigorous foreign body reaction was seen with porcine collagen which caused intestinal obstruction in 5 out of 12 animals within 3 months.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800751010</identifier><identifier>PMID: 3219544</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Absorption ; Alginates ; Animals ; Biological and medical sciences ; calcium alginate ; Cellulose, Oxidized ; Collagen ; Glucuronic Acid ; Haemostasis ; Hemorrhage - pathology ; Hemorrhage - physiopathology ; Hemostasis, Surgical ; Hexuronic Acids ; Liver - pathology ; Liver Diseases - pathology ; Liver Diseases - physiopathology ; Medical sciences ; Miscellaneous ; oxidized cellulose ; porcine collagen ; Rabbits ; Random Allocation ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Equipment ; Time Factors</subject><ispartof>British journal of surgery, 1988-10, Vol.75 (10), p.969-971</ispartof><rights>Copyright © 1988 British Journal of Surgery Society Ltd.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3490-e07c4be4fd651a44a731348b741fa4e3dfb8f5834efb51b9441718db9aa530b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800751010$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800751010$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7114030$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3219544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blair, S. D.</creatorcontrib><creatorcontrib>Backhouse, C. M.</creatorcontrib><creatorcontrib>Harper, R.</creatorcontrib><creatorcontrib>Matthews, J.</creatorcontrib><creatorcontrib>McCollum, C. N.</creatorcontrib><title>Comparison of absorbable materials for surgical haemostasis</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>The haemostatic effect of two new materials has been compared with surgical gauze and oxidized cellulose using a standardized liver laceration in New Zealand White rabbits. Following excision of a 3 cm2 disc of tissue from the liver, 42 rabbits were randomized to the use of gauze swabs (n = 6), oxidized cellulose (Surgicel®) (n = 12), porcine collagen (Medistat®) (n = 12) or calcium alginate (Kaltostat®) (n = 12) to control the resulting haemorrhage. Blood loss and time to haemostasis were accurately recorded. The absorbable materials were left in situ and animals killed between 2 weeks and 6 months later to examine speed of absorption and resulting adhesions. Calcium alginate stopped bleeding in <3 min in all animals compared with a mean (±s.e.m.) of 5.7 ± 0.75 min for porcine collagen, 12.5 ± 0.9 min for oxidized cellulose and > 15min with gauze (P<0.001). Oxidized cellulose and calcium alginate reabsorbed within 3 months leaving a fibrous scar, but a vigorous foreign body reaction was seen with porcine collagen which caused intestinal obstruction in 5 out of 12 animals within 3 months.</description><subject>Absorption</subject><subject>Alginates</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calcium alginate</subject><subject>Cellulose, Oxidized</subject><subject>Collagen</subject><subject>Glucuronic Acid</subject><subject>Haemostasis</subject><subject>Hemorrhage - pathology</subject><subject>Hemorrhage - physiopathology</subject><subject>Hemostasis, Surgical</subject><subject>Hexuronic Acids</subject><subject>Liver - pathology</subject><subject>Liver Diseases - pathology</subject><subject>Liver Diseases - physiopathology</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>oxidized cellulose</subject><subject>porcine collagen</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Equipment</subject><subject>Time Factors</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LAzEQxYMoWj-u3oQ9iLfVmU2yyeJJi5-IFlQ8hsk20ehutyYt6n_vSks9DTPv9wbeY2wf4RgBihP7no5RAyiJgLDGBshLmRdY6nU2gP6eIy_4FttO6R0AOchik23yAispxICdDrt2SjGkbpJ1PiObumjJNi5raeZioCZlvotZmsfXUFOTvZFruzSjFNIu2_C97vaWc4c9X148Da_zu4erm-HZXV5zUUHuQNXCOuHHpUQSghRHLrRVAj0Jx8feai81F85bibYSAhXqsa2IJAeLfIcdLf5OY_c5d2lm2pBq1zQ0cd08GaVLoTX_Aw-W4Ny2bmymMbQUf8wyba8fLnVKfRYfaVKHtMIUogAOPVYtsK_QuJ-VjGD-Gjd94-a_cXN--_i_9d584Q1p5r5XXoofplRcSfNyf2VGqixGQ1WZEf8FvyqCaQ</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>Blair, S. D.</creator><creator>Backhouse, C. M.</creator><creator>Harper, R.</creator><creator>Matthews, J.</creator><creator>McCollum, C. N.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198810</creationdate><title>Comparison of absorbable materials for surgical haemostasis</title><author>Blair, S. D. ; Backhouse, C. M. ; Harper, R. ; Matthews, J. ; McCollum, C. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3490-e07c4be4fd651a44a731348b741fa4e3dfb8f5834efb51b9441718db9aa530b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Absorption</topic><topic>Alginates</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calcium alginate</topic><topic>Cellulose, Oxidized</topic><topic>Collagen</topic><topic>Glucuronic Acid</topic><topic>Haemostasis</topic><topic>Hemorrhage - pathology</topic><topic>Hemorrhage - physiopathology</topic><topic>Hemostasis, Surgical</topic><topic>Hexuronic Acids</topic><topic>Liver - pathology</topic><topic>Liver Diseases - pathology</topic><topic>Liver Diseases - physiopathology</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>oxidized cellulose</topic><topic>porcine collagen</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical Equipment</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blair, S. D.</creatorcontrib><creatorcontrib>Backhouse, C. M.</creatorcontrib><creatorcontrib>Harper, R.</creatorcontrib><creatorcontrib>Matthews, J.</creatorcontrib><creatorcontrib>McCollum, C. N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blair, S. D.</au><au>Backhouse, C. M.</au><au>Harper, R.</au><au>Matthews, J.</au><au>McCollum, C. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of absorbable materials for surgical haemostasis</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1988-10</date><risdate>1988</risdate><volume>75</volume><issue>10</issue><spage>969</spage><epage>971</epage><pages>969-971</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>The haemostatic effect of two new materials has been compared with surgical gauze and oxidized cellulose using a standardized liver laceration in New Zealand White rabbits. Following excision of a 3 cm2 disc of tissue from the liver, 42 rabbits were randomized to the use of gauze swabs (n = 6), oxidized cellulose (Surgicel®) (n = 12), porcine collagen (Medistat®) (n = 12) or calcium alginate (Kaltostat®) (n = 12) to control the resulting haemorrhage. Blood loss and time to haemostasis were accurately recorded. The absorbable materials were left in situ and animals killed between 2 weeks and 6 months later to examine speed of absorption and resulting adhesions. Calcium alginate stopped bleeding in <3 min in all animals compared with a mean (±s.e.m.) of 5.7 ± 0.75 min for porcine collagen, 12.5 ± 0.9 min for oxidized cellulose and > 15min with gauze (P<0.001). Oxidized cellulose and calcium alginate reabsorbed within 3 months leaving a fibrous scar, but a vigorous foreign body reaction was seen with porcine collagen which caused intestinal obstruction in 5 out of 12 animals within 3 months.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>3219544</pmid><doi>10.1002/bjs.1800751010</doi><tpages>3</tpages></addata></record> |
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| subjects | Absorption Alginates Animals Biological and medical sciences calcium alginate Cellulose, Oxidized Collagen Glucuronic Acid Haemostasis Hemorrhage - pathology Hemorrhage - physiopathology Hemostasis, Surgical Hexuronic Acids Liver - pathology Liver Diseases - pathology Liver Diseases - physiopathology Medical sciences Miscellaneous oxidized cellulose porcine collagen Rabbits Random Allocation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Equipment Time Factors |
| title | Comparison of absorbable materials for surgical haemostasis |
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